Protein Alignment Cngl and KCNH5

DIOPT Version :9

• Sequence 1: NP_001245691.1
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: NP_647479.2
• Gene: KCNH5 / 27133
• HGNCID: 6254
• Length: 988
• Species: Homo sapiens
• Alignment Length: 1027
• Identity: 213/1027 - (20%)
• Similarity: 370/1027 - (36%)
• Gaps: 305/1027 - (29%)

  Fly   160 SNQRWMKL----RTTVQISSAIQKKPPLKREDSFLKRFSTRQIPETQETVEDTGSESASGDVDKS 220
            |.:.|.|.    |......|.:|:..|:.:.:...|.....::.:       .||:...
Human   142 STKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQ-------LGSDILP------ 193

  Fly   221 VKRRRRYLQKRRSVVNPDENFYFY--------WLMML-----TVCVLYNLWTLIVRQSFPELQQS 272
                 :|  |:.:...|......|        |::::     .:.|.||:       ||...|.:
Human   194 -----QY--KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNV-------SFKTKQNN 244

  Fly   273 VPTFWLICDSMTDVVFILDIIVQLRTGYLEQGLMVYDDRKL-ACHYVHSRDFIFDMIALIPLDLL 336
            :.  ||:.||:.||:|::||::...|.::..|..|..|.|| ..:|:.:. |:.|:::.:|.|::
Human   245 IA--WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDII 306

  Fly   337 ----QLKMGTHPL---LRFTRFFKVYRSVR--FYYIVESRTVWPNLWRVVNLIHILLILAHWFGC 392
                .:..|...|   |:..|..::.|..|  .:|:.....|      :|.|:.:..::|||..|
Human   307 NAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAV------LVLLVCVFGLVAHWLAC 365

  Fly   393 FYFLLSEAEGFQ--------GDWVY--------PYRPGDYATL-------TRKYLGSLYWSTLTL 434
            .::.:.:.|...        ..|:|        |||....|.:       ...|:.|||::..:|
Human   366 IWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSL 430

  Fly   435 TTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHH 498
            |||| ....|.|:.|.:|::...::|..::|||.|.|..:.....||...:..:|:..:.:::.:
Human   431 TTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLY 495

  Fly   499 KVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPE 563
            :||.|:..||:.:...:||..:   |.|....|.:.|..::.::.:|:|..|..:...|:.....
Human   496 QVPKGLSERVMDYIVSTWSMSK---GIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDG 557

  Fly   564 FLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFGEIGILNL 628
            .|..|.::.:.....|||.|...||....:..:..|.|||:.: .:|:..:..||.||:| ....
Human   558 CLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQD-DEVVAILGKGDVFGDI-FWKE 620

  Fly   629 DGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCVNKKYAKAQSDK 693
            ..|....|:||::.|.:|..:.||.:|..:..|
Human   621 TTLAHACANVRALTYCDLHIIKREALLKVLDFY-------------------------------- 653

  Fly   694 EAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDVKGFRNVLKKSRTSRKSDESLEM 758
              .|:|                      ||.|:.               |..:...||
Human   654 --TAFA----------------------NSFSRN---------------LTLTCNLRK------- 672

  Fly   759 QPLHNTSPRGSKILLKRMSRVRSDEKDADSAEAKDELHDKTPSPIGAGLPLLQRLRLL--KEKQD 821
                       :|:.:::|.|:.:|        ::.|..|  :.:...:|:...:|.|  |.||.
Human   673 -----------RIIFRKISDVKKEE--------EERLRQK--NEVTLSIPVDHPVRKLFQKFKQQ 716

  Fly   822 REERAVKSTPPQKSPPHSHVTCTLSPQESIQEEPEREFSEGFPLIQRLQQLKIKNEPQANAAE-- 884
            :|                     |..|.|.|.:|||            .||::::....|.|.
Human   717 KE---------------------LRNQGSTQGDPER------------NQLQVESRSLQNGASIT 748

  Fly   885 -PGVVMVN--TPPNIS---SKIDSHFAASQAGASHPGPNGGA----IGISAPGQSLTVAQIKPIM 939
             ..||.|:  ||...|   .|.......:...|....|||||    :.:::|
Human   749 GTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMELKPNGGADQKCLKVNSP------------- 800

  Fly   940 KVSFKQKIQQMQGGGG----------GASSSPGPSTGAIAKKEPPKSLALVAKHATSEDPVAAAG 994
                    .:|:.|.|          ||..........:.|.|....|:...|.:.||:.|....
Human   801 --------IRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLLSEDPKSSDSENSVTKNP 857

  Fly   995 LGLGSGSSSGIATISKRVVK------PQSHRMATPLQSDTDTDGTPIKPWSKLKLAT-------- 1045
            |.......|||.....|:.|      |..|   :|:|:|..   .|..|..:..|.|
Human   858 LRKTDSCDSGITKSDLRLDKAGEARSPLEH---SPIQADAK---HPFYPIPEQALQTTLQEVKHE 916

  Fly  1046 ------LMSSSYTSLTNCSPDDLASPLKNYSLSNIPQ------QMESHTRPR 1085
                  |:|...|:|..    .:|..||..|..::||      ||.....|:
Human   917 LKEDIQLLSCRMTALEK----QVAEILKILSEKSVPQASSPKSQMPLQVPPQ 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	64/254 (25%)
		Ion_trans_2	382..476	CDD:285168	30/117 (26%)
		Crp	550..>680	CDD:223736	30/129 (23%)
		CAP_ED	556..668	CDD:237999	29/111 (26%)
KCNH5	NP_647479.2	PAS_9	39..132	CDD:404329
		PLN03192	217..>616	CDD:215625	102/418 (24%)
		Selectivity filter. /evidence=ECO:0000250	432..437		3/4 (75%)
		Crp	544..725	CDD:223736	53/302 (18%)
		Calmodulin-binding. /evidence=ECO:0000255	704..715		3/10 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	717..742		10/57 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	838..890		13/54 (24%)
		CAD (involved in subunit assembly). /evidence=ECO:0000250	909..948		8/42 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	969..988

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145037
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840