DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and Kcnh8

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_659563.1	Gene:	Kcnh8 / 246325	RGDID:	2549	Length:	1102	Species:	Rattus norvegicus

Alignment Length:	1100	Identity:	235/1100 - (21%)
Similarity:	429/1100 - (39%)	Gaps:	270/1100 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 SNQRWMKLRTTVQISSAIQKKPPLKREDSFLKR-------------------------FSTRQIP 199
            :|::.|     :||..::::|...|.|..|.|:                         .|.:.|.
  Rat    75 TNEQLM-----LQIEKSLEEKVEFKGEIMFYKKNGAPFWCLLDIVPIKNEKGDVVLFLASFKDIT 134

  Fly   200 ETQE--TVEDTGSE-----SASGDVDKSVKRRRR--------YLQKR-RSVVNPDENFY------ 242
            :|:.  |.||...:     |.:|....|.:||.|        :||:| ::.:..:.|.:
  Rat   135 DTKVKITSEDKKEDRAKGRSRAGSHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAF 199

  Fly   243 ------------------------FYWLMML-----TVCVLYNLWTLIVRQSFPELQQSVPTFWL 278
                                    :.||::|     .|.|.||: ..|..:.....:.:.
  Rat   200 PEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNV-CFIGNEDLSTTRSTT----- 258

  Fly   279 ICDSMTDVVFILDIIVQLRTGYL-EQGLMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGT 342
            :.|...:::||:|||:..||.|: :.|.::::.|.:..||| :..||.|:||.:|.|||.....|
  Rat   259 VSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYV-TTWFIIDLIAALPFDLLYAFNVT 322

  Fly   343 HPLLRFTRFFKVYRSVRFYYIVESRTVWPNLWRVV--NLIHILLILAHWFGCFYFLLSEAE---- 401
              ::......|..|.:|...:::....:.....:|  .|:.:..:||||..|.::::.:.|
  Rat   323 --VVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDN 385

  Fly   402 ---GFQGDWVY--------PYRPGDY---ATLTRKYLGSLYWSTLTLTTIG-DLPTPETNAEYIF 451
               .::..|::        ||...:.   .::...|:.:||::..:||::| ...:..|:||.||
  Rat   386 SLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIF 450

  Fly   452 TIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSW 516
            :|.:.|||..:.|.:.|.|..:|....:....:.......|.::|.|.:|..:|:|:|.::..:|
  Rat   451 SICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTW 515

  Fly   517 SRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGD 581
            |   :..|.|.|..|...||:|::::.:|:|..:| ::::|:......|..|.|.:|.....||:
  Rat   516 S---VNNGIDSNELLKDFPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGE 576

  Fly   582 SICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFGEIGILNL---DGLNKRTADVRSVGY 643
            .:.|:|:..:.::.:..|.:|||.:: .||..:..||..|    .||   |.:.|..|||:::.|
  Rat   577 YLLRQGDALQAIYFVCSGSMEVLKDS-MVLAILGKGDLIG----ANLSIKDQVIKTNADVKALTY 636

  Fly   644 SELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCVNKKYA-KAQSDKEAAAYAAAHPHHHQ 707
            .:                      ||.:..|.|.||..:..:|| |...|.:          |..
  Rat   637 CD----------------------LQCIILKGLFEVLGLYPEYAHKFVEDIQ----------HDL 669

  Fly   708 SHHQGQVHQSDSSENSASKKIVDKLKHDVKGFRNVLKK--SRTSRKSDESLEMQPLHNTSP---R 767
            :::..:.|:||.....::|..|.:.  :.||..::.|:  |....:.:|.:|.:...:.||   |
  Rat   670 TYNLREGHESDVISRLSNKSTVPQA--EPKGNGSIKKRLPSIVEDEEEEEVEEEETTSLSPIYTR 732

  Fly   768 GSKILLKRMSRVRSDEKDADSAEAKDELHDKTPSPIGAGLPLLQRLRLLKEKQDREERAVKSTPP 832
            ||.:         |..|...|::          |.:|..|..|....:......|...|......
  Rat   733 GSSV---------SHSKKTGSSK----------SYLGLSLKQLTSGTVPFHSPIRVSSANSPKTK 778

  Fly   833 QKSPPHSHVT----------CT--------LSPQ--ESIQEEPEREFSEGFPLIQRLQQLKIKNE 877
            |::.|.:|.|          |:        |||:  :.|::....|.::.|.......:.:.:..
  Rat   779 QEADPPNHGTRKEKNLKVQLCSLGTAGTPELSPRIVDGIEDGNSSEETQTFDFGSEQIRPEPRIS 843

  Fly   878 PQANAAEPGVVMV-----NTPPNISSKIDSHFAASQAGASHPGPNGGAI-----GISAPGQSLTV 932
            |....:|.|...:     .|...| :|::|.........|..|.:..:|     .|.:|.|....
  Rat   844 PSLGESEIGAAFLFIKAEETKQQI-NKLNSEVTTLTQEVSQLGKDMRSIMQLLENILSPQQPSQF 907

  Fly   933 AQIKPI----MKVSFKQKIQ--------QMQGGG-----GGASSSPGPSTGAIAKKEPPKSLALV 980
            ..:.|.    .:.||:.::.        .:|..|     |..:|.......::....|.::.|..
  Rat   908 CSLHPTSICPSRESFQTRVSWSAHQPCLHLQANGAHLYHGNVTSDIWSVDPSLVGSNPQRTEAHE 972

  Fly   981 AKHATSE---DPVAAAGLGLGSGSSSGIATISK------RVVKPQSHRMATPLQSDTDTDGTPIK 1036
            .....||   .|..|.       |.|....|.:      |.:.|.|....|||||.:.|
  Rat   973 QSPVDSELHHSPNLAY-------SPSHCQVIQEGHLQFLRCISPHSDTTLTPLQSISAT------ 1024

  Fly  1037 PWSKLKLATLMSSSYTSLTNCSPDD------LASPLKNYSLSNIP------QQMESHTRP 1084
                 ..:::.|||.|||....|..      ...|:.::||.|:|      ..|.:.|.|
  Rat  1025 -----LSSSVCSSSETSLHLVLPSRSEEGSITHGPVSSFSLENLPGSWDREGMMSASTEP 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	58/242 (24%)
		Ion_trans_2	382..476	CDD:285168	28/112 (25%)
		Crp	550..>680	CDD:223736	32/132 (24%)
		CAP_ED	556..668	CDD:237999	26/114 (23%)
Kcnh8	NP_659563.1	PAS_9	29..135	CDD:290162	11/64 (17%)
		PAS	42..133	CDD:238075	10/62 (16%)
		Ion_trans	239..481	CDD:278921	61/250 (24%)
		Ion_trans_2	<421..475	CDD:285168	19/53 (36%)
		Selectivity filter. /evidence=ECO:0000250	434..439		1/4 (25%)
		Crp	548..707	CDD:223736	45/197 (23%)
		CAP_ED	551..662	CDD:237999	35/137 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	683..744		15/71 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..793		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..845		2/26 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..983		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840