DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cngl and Kcnh5

DIOPT Version :9

Sequence 1:NP_001245691.1 Gene:Cngl / 32468 FlyBaseID:FBgn0263257 Length:1970 Species:Drosophila melanogaster
Sequence 2:NP_766393.2 Gene:Kcnh5 / 238271 MGIID:3584508 Length:988 Species:Mus musculus


Alignment Length:1013 Identity:214/1013 - (21%)
Similarity:372/1013 - (36%) Gaps:285/1013 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   160 SNQRWMKL----RTTVQISSAIQKKPPLKREDSFLKRFSTRQIPETQETVEDTGSESASGDVDKS 220
            |.:.|.|.    |......|.:|:..|:.:.::..|.....::.:       .||:...      
Mouse   142 STKGWTKFARLTRALTNSRSVLQQLTPMNKTETVHKHSRLAEVLQ-------LGSDILP------ 193

  Fly   221 VKRRRRYLQKRRSVVNPDENFYFY--------WLMML-----TVCVLYNLWTLIVRQSFPELQQS 272
                 :|  |:.:...|......|        |::::     .:.|.||:       ||...|.:
Mouse   194 -----QY--KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNV-------SFKTKQNN 244

  Fly   273 VPTFWLICDSMTDVVFILDIIVQLRTGYLEQGLMVYDDRKL-ACHYVHSRDFIFDMIALIPLDLL 336
            :.  ||:.||:.||:|::||::...|.::..|..|..|.|| ..:|:.:. |:.|:::.:|.|::
Mouse   245 IA--WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDII 306

  Fly   337 ----QLKMGTHPL---LRFTRFFKVYRSVR--FYYIVESRTVWPNLWRVVNLIHILLILAHWFGC 392
                .:..|...|   |:..|..::.|..|  .:|:.....|      :|.|:.:..::|||..|
Mouse   307 NAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAV------LVLLVCVFGLVAHWLAC 365

  Fly   393 FYFLLSEAEGFQ--------GDWVY--------PYRPGDYATL-------TRKYLGSLYWSTLTL 434
            .::.:.:.|...        ..|:|        |||....|.:       ...|:.|||::..:|
Mouse   366 IWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSL 430

  Fly   435 TTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHH 498
            |||| ....|.|:.|.:|::...::|..::|||.|.|..:.....||...:..:|:..:.:::.:
Mouse   431 TTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLY 495

  Fly   499 KVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPE 563
            :||.|:..||:.:...:||..:   |.|....|.:.|..::.::.:|:|..|..:...|:.....
Mouse   496 QVPKGLSERVMDYIVSTWSMSK---GIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDG 557

  Fly   564 FLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFGEIGILNL 628
            .|..|.::.:.....|||.|...||....:..:..|.|||:.:. :|:..:..||.||:| ....
Mouse   558 CLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDE-EVVAILGKGDVFGDI-FWKE 620

  Fly   629 DGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCVNKKYAKAQSDK 693
            ..|....|:||::.|.:|..:.||.:|..:..|                                
Mouse   621 TTLAHACANVRALTYCDLHIIKREALLKVLDFY-------------------------------- 653

  Fly   694 EAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDVKGFRNVLKKSRTSRKSDESLEM 758
              .|:|                      ||.|:.               |..:...||       
Mouse   654 --TAFA----------------------NSFSRN---------------LTLTCNLRK------- 672

  Fly   759 QPLHNTSPRGSKILLKRMSRVRSDEKDADSAEAKDELHDKTPSPIGAGLPLLQRLRLL--KEKQD 821
                       :|:.:::|.|:.:|        ::.|..|  :.:...:|:...:|.|  |.||.
Mouse   673 -----------RIIFRKISDVKKEE--------EERLRQK--NEVTLSIPVDHPVRKLFQKFKQQ 716

  Fly   822 REERAVKSTPPQKSPPHSHVTCTLSPQESIQEEPEREFSEGFPLIQRLQQLKIKNEPQANAAE-- 884
            :|.|.                     |.|.|.:|||            .||::::.|..|.|.  
Mouse   717 KELRI---------------------QGSAQSDPER------------SQLQVESRPLQNGASIT 748

  Fly   885 -PGVVMVN--TPPNIS---SKIDSHFAASQAGASHPGPNGGAIGISAPGQSLTVAQIKP-IMKVS 942
             ..||.|:  ||...|   .|.......:...|....|||||               :| .:||:
Mouse   749 GTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMELKPNGGA---------------EPKCLKVN 798

  Fly   943 FKQKIQQMQGGGG-------GASSSPGPSTGAIAKKEPPKSLALVAKHATSEDPVAAAGLGLGSG 1000
            ...:::...|.|.       ||..........:.|.|....|:...|.:.||:.|....|.....
Mouse   799 SPIRMKNGNGKGWLRLKNNMGAQEEKKEDWNNVTKAESMGLLSEDPKGSDSENSVTKNPLRKTDS 863

  Fly  1001 SSSGIATISKRVVK------PQSHRMATPLQSDTDTDGTPIKPWSKLKLA------------TLM 1047
            ..|||.....|:.|      |..|   :|.|:|......|| |...|:..            .|:
Mouse   864 CDSGITKSDLRLDKAGEARSPLEH---SPSQADVKHSFYPI-PEQALQTTLQEVKHELKEDIQLL 924

  Fly  1048 SSSYTSLTNCSPDDLASPLKNYSLSNIPQQMESHTRPR 1085
            |...|:|..    .:|..||..|..::||  .|..:|:
Mouse   925 SCRMTALEK----QVAEILKLLSEKSVPQ--TSSPKPQ 956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CnglNP_001245691.1 Ion_trans 260..481 CDD:278921 64/254 (25%)
Ion_trans_2 382..476 CDD:285168 30/117 (26%)
Crp 550..>680 CDD:223736 30/129 (23%)
CAP_ED 556..668 CDD:237999 29/111 (26%)
Kcnh5NP_766393.2 PAS 37..131 CDD:238075
PAS_3 40..127 CDD:285623
Ion_trans 232..479 CDD:278921 68/262 (26%)
Ion_trans_2 <419..473 CDD:285168 19/53 (36%)
Selectivity filter. /evidence=ECO:0000250 432..437 3/4 (75%)
Crp 544..723 CDD:223736 52/300 (17%)
CAP_ED 550..660 CDD:237999 32/167 (19%)
Calmodulin-binding. /evidence=ECO:0000255 704..715 3/10 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 721..741 8/52 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 838..893 15/57 (26%)
CAD (involved in subunit assembly). /evidence=ECO:0000250 909..948 8/42 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167835146
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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