DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cngl and KCNH4

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_036417.1	Gene:	KCNH4 / 23415	HGNCID:	6253	Length:	1017	Species:	Homo sapiens

Alignment Length:	846	Identity:	189/846 - (22%)
Similarity:	325/846 - (38%)	Gaps:	185/846 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 PLKRE--DSFLKRFSTRQIPETQETVEDTGSESASGDVD--------------KSVKRRRRYLQK 230
            |:|.|  :..|..||.:.|  ||......|.:...||.:              :|.:||.|.:..
Human   115 PIKNEMGEVVLFLFSFKDI--TQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLH 177

  Fly   231 R----------------RSVVNPDENFYFYWL--------MMLTVCVLYNLWT-LIVRQSFPELQ 270
            |                .:|..|..:...|.:        ::|...|...:|. ||:..:| .:.
Human   178 RLTGHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATF-YVA 241

  Fly   271 QSVP---------------TFWLICDSMTDVVFILDIIVQLRTGYLEQ-GLMVYDDRKLACHYVH 319
            .:||               ...|:.|...:::||||||:..||.|:.| |.::...|.:..||:.
Human   242 VTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLA 306

  Fly   320 SRDFIFDMIALIPLDLLQLKMGTHPLLRFTRFFKVYRSVRFYYIVESRTVWPNLWRVV--NLIHI 382
            :..|| |:||.:|.|||.:...|  :.......|..|.:|...:::....:.....||  .|:.:
Human   307 TWFFI-DLIAALPFDLLYIFNIT--VTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSV 368

  Fly   383 LLILAHWFGCFYFLLSEAEGFQGD-------WVY--------PYRPGDYATLTRK--YLGSLYWS 430
            ..:||||..|.::::...|....|       |::        ||..|.....:|:  |:.:||::
Human   369 FALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFT 433

  Fly   431 TLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTY 494
            ..:||::| ......|:||.||:|.:.|||..:.|.:.|.|..:|....:.|..:...:...|.:
Human   434 LSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDF 498

  Fly   495 MRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQE 559
            :|.|::|..:|:|:|.::..:|:   :..|.|.|..|...||:|:.::|:|:|..:| ::.:|..
Human   499 IRVHRLPRPLKQRMLEYFQTTWA---VNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGA 559

  Fly   560 CQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFG--- 621
            .....|..|.|.:|.....||:.:.|:|:..:..:.:..|.||||.: ..||..:..||..|
Human   560 ASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRD-NMVLAILGKGDLIGADI 623

  Fly   622 -----EIGI-LNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQT-LGRKRLMEV 679
                 |.|: .:.:.:.|.:|||:::.|..|..||...:...::.||:.....:. |.|.....:
Human   624 PEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNL 688

  Fly   680 RCVNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASK------------------ 726
            |        ..||....:..:..|...|...:.....||.:..|.::
Human   689 R--------QGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLL 745

  Fly   727 -----------KIVDKLKHDVKGFRNVLKKSRTSRKSDESLEMQPLHNTSPRG----------SK 770
                       .:|..|..::..|..::.....|.....:|..|. |:.||.|          .:
Human   746 LPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLSPALAGQG-HSASPHGPPRCSAAWKPPQ 809

  Fly   771 ILLKRMSR----------VRSDEKDADSAEAKDELHDKTPSPIGAGLPLLQRLRLLKEKQDREER 825
            :|:..:..          |...|....:|||......:.|.     ||                |
Human   810 LLIPPLGTFGPPDLSPRIVDGIEDSGSTAEAPSFRFSRRPE-----LP----------------R 853

  Fly   826 AVKSTPPQKSPPHSHVTCTLSPQESIQEEPEREFSEGFPLIQRLQQLK-----IKNEPQANAAEP 885
            .....||..:.|...:.   |..|.::|:..|...|...|.|.:.||.     |....||....|
Human   854 PRSQAPPTGTRPSPELA---SEAEEVKEKVCRLNQEISRLNQEVSQLSRELRHIMGLLQARLGPP 915

  Fly   886 G 886
            |
Human   916 G 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	68/256 (27%)
		Ion_trans_2	382..476	CDD:285168	31/111 (28%)
		Crp	550..>680	CDD:223736	34/139 (24%)
		CAP_ED	556..668	CDD:237999	31/120 (26%)
KCNH4	NP_036417.1	PAS_9	29..135	CDD:290162	7/21 (33%)
		PAS	29..133	CDD:238075	6/17 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..157		3/18 (17%)
		Ion_trans	244..486	CDD:278921	65/244 (27%)
		Ion_trans_2	<426..480	CDD:285168	19/53 (36%)
		Selectivity filter. /evidence=ECO:0000250	439..444		1/4 (25%)
		CAP_ED	556..676	CDD:237999	31/120 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..749		7/57 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	772..803		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..875		13/77 (17%)
		PHA02682	838..>999	CDD:177464	24/103 (23%)
		bZIP	<872..901	CDD:304365	8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..1017
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145046
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840