DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and cng-2

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_001343690.1	Gene:	cng-2 / 190732	WormBaseID:	WBGene00022295	Length:	819	Species:	Caenorhabditis elegans

Alignment Length:	653	Identity:	182/653 - (27%)
Similarity:	300/653 - (45%)	Gaps:	122/653 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 GGHSDGGYHKRHHHKMVRDDDNNSAAHSSDSKSPSQRKSRIGDGASDPD----SDWTRSNQRWMK 166
            |||:.....:..|||:    |.|    .|.|.|.::|||....||.||.    ||..::.   |.
Worm   102 GGHAKEVTFQERHHKL----DLN----KSRSTSKNRRKSAQNGGAEDPGQKSFSDVVKTA---MM 155

  Fly   167 LRTTVQISSAIQKKPPLKREDSFLKRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKR 231
            |||.:   ||::..   :||..          |:...|.  |.:|..:.| |:|:.......|:|
Worm   156 LRTWI---SAMEHD---ERESE----------PDRDATT--TNAEITAAD-DRSILPSPPIFQQR 201

  Fly   232 RS-------------------VVNPDENFYFYWLMMLTVCVLYNLWTLIVRQSFPELQQSVPTFW 277
            ::                   .|..:..|::||..::::.:|||::.::: ..|.::.......|
Worm   202 QTGFTQIKDILTDKCRKLYYFYVTENSTFFYYWTAIISIGILYNMFAMVI-FIFDDVHFGYFNQW 265

  Fly   278 LICDSMTDVVFILDIIVQLRTGYLEQGLMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGT 342
            |..:...|..|:||.:|..|..::.:|..|....|:..:|..||....|::.|.|.|........
Worm   266 LYVNLFFDFCFLLDCLVGSRMTFVSEGNEVSQTDKMFKNYRQSRRCKLDLLCLAPADFYLFIDTK 330

  Fly   343 HPLLRFTRFFKVYRSVRFYYIVESRTVWPNLWRVVNLIHILLILAHWFGCFYFLLSEAEG----- 402
            ..|:|..|..|.||...|..:.:.||.:|:..:::.|.....||.||..|.|||.|..:|
Worm   331 ASLVRAIRLVKAYRLYEFIMLTQRRTDFPHFMKILFLTSSCAILFHWNACVYFLFSLYQGLTEDD 395

  Fly   403 ----------------------FQGDWVYP-------------------YRPGD-------YATL 419
                                  :..|..||                   |:..|       ....
Worm   396 PNAFGFSYYKVFDPRFSICDALYDQDCYYPEDTEVLDIRDERPHYMEDMYKFWDKKFNILQIGNF 460

  Fly   420 TRKYLGSLYWSTLTLTTIGDLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEF 484
            :|:|..::|||:||:|..|..|.|..:::....|...||||.:||||:|.||:|:|..:.|..:|
Worm   461 SREYSMTIYWSSLTITKCGQQPWPSKSSQNSLEIFDTLIGVLVFATIIGGVGSVVTQMSQNVNDF 525

  Fly   485 ERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLS 549
            ..::||.|.||::..|...::.|||..:.|..|..::.   |....|.|||...:..:|.:::..
Worm   526 REMMDGIKFYMKYRGVQSAIQDRVLNCFLYLNSHNQLY---DEEEILSLLPPFFQARIAANLHQD 587

  Fly   550 VLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVL-SETGKVLTT 613
            .|.||::|.:|....|.::|:.:|..:::|.|.:|||.|.|:||||:..|:|.|: .:||..|.:
Worm   588 TLSKVSLFYKCDQRLLQEVVMLVKQQVYSPNDYLCRKNEKAKEMFIVKKGLLAVIDDDTGVELDS 652

  Fly   614 MKAGDFFGEIGILNLDGL---NKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKR 675
            :|.|..|||:.|:.:.|.   ::|:..:||||||:::.|.::||...:::||:.        |.|
Worm   653 LKEGHTFGELSIVQVKGNILGDRRSVSLRSVGYSDVYVLHQDDVTRLLQEYPEE--------RVR 709

  Fly   676 LME 678
            |||
Worm   710 LME 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	70/273 (26%)
		Ion_trans_2	382..476	CDD:285168	39/146 (27%)
		Crp	550..>680	CDD:223736	49/133 (37%)
		CAP_ED	556..668	CDD:237999	41/115 (36%)
cng-2	NP_001343690.1	Ion_trans	232..>407	CDD:366146	45/175 (26%)
		PLN03192	<457..>713	CDD:215625	93/267 (35%)
		CAP_ED	594..711	CDD:237999	43/124 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158451
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850