DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and Kcnh3

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	XP_006520546.1	Gene:	Kcnh3 / 16512	MGIID:	1341723	Length:	1101	Species:	Mus musculus

Alignment Length:	1095	Identity:	227/1095 - (20%)
Similarity:	392/1095 - (35%)	Gaps:	308/1095 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 HKMVRDDDNNSAAHSSDSKSPS-------QRKSRIGDGASDPDSDWTRSNQRWMKLRTTV-QISS 175
            ||.:.:..|.....:...:.||       :|..|.|       |....:|:|  :.|..: .:|.
Mouse   130 HKDISETKNRGGPDNWKEREPSFLVGGGRRRYGRAG-------SKGFNANRR--RSRAVLYHLSG 185

  Fly   176 AIQKKPPLKR--------EDSFLKRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKRR 232
            .:||:|..|.        |...|..:....|.::...:...|:..|:.|
Mouse   186 HLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWD---------------- 234

  Fly   233 SVVNPDENFYFYWLMMLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLR 297
                   .|.....:.:.|.|.|::.....|:  |...:..|:   :||...:|:|||||::..|
Mouse   235 -------GFILLATLYVAVTVPYSVCVSTARE--PSAARGPPS---VCDLAVEVLFILDIVLNFR 287

  Fly   298 TGYL-EQGLMVYDDRKLACHYVHSRDFIFDMIALIPLDLL-----QLKMGTHPLLRFTRFFKVYR 356
            |.:: :.|.:|:..:.:..||| :..|:.|:||.:|.|||     .:.:|.| ||:..|..::.|
Mouse   288 TTFVSKSGQVVFAPKSICLHYV-TTWFLLDVIAALPFDLLHAFKVNVYVGAH-LLKTVRLLRLLR 350

  Fly   357 SVRFYYIVESRTVWPNLWR--------VVNLIHILLILAHWFGCFYFLL-------SEAEGFQGD 406
                        :.|.|.|        :..|:.:..:||||..|.:|.:       ||:|..:..
Mouse   351 ------------LLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQQEIESSESELPEIG 403

  Fly   407 WVY--------PY----RPGDYA-------------------------------------TLTRK 422
            |:.        ||    |..|..                                     :|...
Mouse   404 WLQELARRLETPYYLVSRSPDGGNSSGQSENCSSSSSSSGSGGGRGSEANGTGLELLGGPSLRSA 468

  Fly   423 YLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFER 486
            |:.|||::..:||::| ...:..|:.|.||:|.:.|||..:.|.:.|.|..:|....|.|..:..
Mouse   469 YITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHS 533

  Fly   487 LLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVL 551
            .....:.|:|.|::|..:|:|:|.::..:|:   :..|.|....|..|||:|:.::|:|::..||
Mouse   534 RTRDLRDYIRIHRIPKPLKQRMLEYFQATWA---VNNGIDTTELLQSLPDELRADIAMHLHKEVL 595

  Fly   552 KKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKA 616
             ::.:|:......|..|.|.::....|||:.:..:|:..:.::.:..|.:||| :.|.||..:..
Mouse   596 -QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVL-KGGTVLAILGK 658

  Fly   617 GDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPD---------AQEILQTLG 672
            ||..| ..:...:.:.|..|||:.:.|..|..|....:..::..||:         ..|:...||
Mouse   659 GDLIG-CELPQREQVVKANADVKGLTYCVLQCLQLAGLHESLALYPEFAPRFSRGLRGELSYNLG 722

  Fly   673 RKRLMEVRCVNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSD-SSENSASKKIVDKLKHDV 736
                                  |...:|            :|..|. |.:|:....:.:|.....
Mouse   723 ----------------------AGGVSA------------EVDTSSLSGDNTLMSTLEEKETDGE 753

  Fly   737 KGFRNVLKKSRTSRKSDE--SLEMQPLHNTSPRGSKILLKRMS--------RVRSDEKDADSAEA 791
            :|      .:.:...:||  |..:.|...:|...:|:|..|.:        |.|.........||
Mouse   754 QG------HTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPSRAGVLKPEA 812

  Fly   792 KDELHDKT-------PSPIGAGLPLLQRLRLLKEKQDREERAVKSTPP-------QKSPPHSH-- 840
            ....|.::       |.|......|..|:      .|..|....|..|       |..|..|.
Mouse   813 GPSAHPRSLDGLQLPPMPWNVPPDLSPRV------VDGIEDGCSSDQPKFSFRVGQSGPECSSSP 871

  Fly   841 --------VTCTLSPQE------------SIQEEPER--EFSEGFPLIQRLQQLKIKNE-----P 878
                    :|..|.|.|            ::.|..|:  :..||...:::..||.:..:     |
Mouse   872 SPGTESGLLTVPLGPSEARNTDTLDKLRQAVMELSEQVLQMREGLQSLRQAVQLILVPQGEGQCP 936

  Fly   879 QANAAEP------GVVMVNTPPNISSKIDSHFAASQAGA------SHPGPNGGAIGISAPGQSLT 931
            :.:..||      |::.   |..:.:...|:.....||:      .||.|
Mouse   937 RGSGEEPCPATASGLLQ---PLRVDTGASSYCLQPPAGSVLSGTWPHPRP--------------- 983

  Fly   932 VAQIKPIMKVSFKQKIQQMQGGGGGASSSPGPSTGAI----AKKEPPKSLALVAKHATSEDPVAA 992
             .|..|:|        .....|...:.|||.|...|:    :..|||.|..|.::.:|...|..:
Mouse   984 -GQPPPLM--------APWPWGPPASQSSPWPRATALWTSTSDSEPPGSGDLCSEPSTPASPPPS 1039

  Fly   993 AGLGLGSGSSSGIATISKRVVKPQSHRMATPLQSDTDTDGTPIKPWSKLKLATLM 1047
            .     .|:.:|...       |.|...||.........|....||....|..::
Mouse  1040 E-----EGARTGTPA-------PVSQAEATSTGEPPPGPGGRALPWDPHSLEMVL 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	71/291 (24%)
		Ion_trans_2	382..476	CDD:285168	34/150 (23%)
		Crp	550..>680	CDD:223736	32/138 (23%)
		CAP_ED	556..668	CDD:237999	28/120 (23%)
Kcnh3	XP_006520546.1	PAS_9	40..135	CDD:379177	2/4 (50%)
		PLN03192	233..>668	CDD:215625	114/482 (24%)
		cyc_nuc_ocin	<623..718	CDD:274839	22/96 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835153
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840