DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and Kcnh2

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_038597.2	Gene:	Kcnh2 / 16511	MGIID:	1341722	Length:	1162	Species:	Mus musculus

Alignment Length:	1024	Identity:	218/1024 - (21%)
Similarity:	381/1024 - (37%)	Gaps:	255/1024 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GAGGSGGAGGHSDGGYHKRHHHKMVRDDDNNSAAHSSDSKS----------------PSQRKSRI 146
            |:..|.||.|            .:|.|.|...||.||:|.:                ..:|::.:
Mouse   183 GSMRSAGAPG------------AVVVDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALV 235

  Fly   147 GDGAS------------------DPDSDW-------TRSNQRWMKLRTT-----VQISSAIQKKP 181
            |.|::                  :||:..       |||.:....:|..     ::...|....|
Mouse   236 GPGSASPVASIRGPHPSPRAQSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGALPP 300

  Fly   182 PLKR-----------------EDSFLKRFST-RQIPETQETVEDTGSES--ASGDVDKSV----- 221
            |.:.                 .||.|.|:.| .:||:......|...:.  ||...|:.:
Mouse   301 PPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKI 365

  Fly   222 -KRRRRYLQKRRSVVN------PD----------------ENFYFYWLMMLTVCVLYN-LWT--- 259
             :|.....:|...|::      |:                ..|...|..::.:.|:|. ::|
Mouse   366 KERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYS 430

  Fly   260 --LIVRQSFPELQQSVPTFWLIC------DSMTDVVFILDIIVQLRTGYLEQG-LMVYDDRKLAC 315
              .:::::  |.....|.....|      |.:.|::||:||::..||.|:... .:|....::|.
Mouse   431 AAFLLKET--EDGSQAPDCGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAV 493

  Fly   316 HYVHSRDFIFDMIALIPLDLLQLKMGTHPLL------RFTRFFKVYRSVRFYYIVESRTVWPNLW 374
            ||.... |:.||:|.||.|||....|:..|:      |..|..:|.|.:..|....:..::
Mouse   494 HYFKGW-FLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLF---- 553

  Fly   375 RVVNLIHILLILAHWFGCFYFLLSEAEGFQGD----WVY--------PYRPGDYA--TLTRKYLG 425
               .|:....::|||..|.::.:...|....|    |::        ||......  ::..||:.
Mouse   554 ---LLMCTFALIAHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVT 615

  Fly   426 SLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLD 489
            :||::..:||::| ...:|.||:|.||:|...|||..::|:|.|.|..:|....:....:...:.
Mouse   616 ALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQML 680

  Fly   490 GAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKV 554
            ..:.::|.|::|..:::|:..::.::||   ...|.|:|..|...|:.|:.::.||:|.|:|:..
Mouse   681 RVREFIRFHQIPNPLRQRLEEYFQHAWS---YTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 742

  Fly   555 TIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDF 619
            ..|:......|..|.:|.|.....|||::...|::...::.|:.|.:|:| ....|:..:...|.
Mouse   743 KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL-RGDVVVAILGKNDI 806

  Fly   620 FGEIGILNLDGL-NKRTADVRSVGYSELFSLSREDVLAAMKDYPD-------AQEILQTL----- 671
            |||  .|||... .|...|||::.|.:|..:.|:|:|..:..||:       :.||...|
Mouse   807 FGE--PLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNM 869

  Fly   672 ----------------GRKRLMEVRCVNKKYAKAQSDKEAAAYAAAHPHHHQS---HHQGQVHQS 717
                            .|||.:..|....|..:...:..|.....|......|   ...|...:|
Mouse   870 IPGSPGSAELESGFNRQRKRKLSFRRRTDKDTEQPGEVSALGQGPARVGPGPSCRGQPGGPWGES 934

  Fly   718 DSSENSASKKIVDKLKHDVKGFRNVLKKSRTSRKSDESLEMQPLHNTSPRGSKILLKRMSRVRSD 782
            .||..|:.:...|:                ...:|...|.:.|..:..|.|
Mouse   935 PSSGPSSPESSEDE----------------GPGRSSSPLRLVPFSSPRPPG-------------- 969

  Fly   783 EKDADSAEAKDELHDK--TPSPI-GAGLPLLQRLRLLKEKQDREERAVKSTP---------PQKS 835
              |....|...|..:|  |.:|: ||...:........:.:.|:.:.:...|         |..|
Mouse   970 --DPPGGEPLTEDGEKSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPAPSLLNIPLSS 1032

  Fly   836 PPHSHVTCTLSPQESIQEEPER---EFSEGFPLIQRLQQLKIKNEPQANAA--EPG--------V 887
            |.........|..:::|.:..|   ..|.....:.:|.|.::...|.|.:|  .||        :
Mouse  1033 PGRRSRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSASPL 1097

  Fly   888 VMVNTPPNISSKIDSHFAASQ--------AGASHPGPNGGAIGISAPGQ 928
            :.|...|.::  :||....||        |||.....:|....:|.|||
Mouse  1098 LPVGPVPTLT--LDSLSQVSQFVAFEELPAGAPELPQDGPTRRLSLPGQ 1144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	64/248 (26%)
		Ion_trans_2	382..476	CDD:285168	31/108 (29%)
		Crp	550..>680	CDD:223736	39/158 (25%)
		CAP_ED	556..668	CDD:237999	33/119 (28%)
Kcnh2	NP_038597.2	PAS_9	29..130	CDD:290162
		PAS	41..132	CDD:238075
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..316		11/82 (13%)
		Ion_trans	451..670	CDD:278921	62/226 (27%)
		Ion_trans_2	<613..667	CDD:285168	21/53 (40%)
		Selectivity filter. /evidence=ECO:0000250	626..631		1/4 (25%)
		Crp	738..>858	CDD:223736	33/122 (27%)
		CAP_ED	744..855	CDD:237999	32/113 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	873..991		25/149 (17%)
		SSTK-IP	1015..1116	CDD:292464	19/102 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1162		8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835156
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840