DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and Hcn3

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_032253.1	Gene:	Hcn3 / 15168	MGIID:	1298211	Length:	779	Species:	Mus musculus

Alignment Length:	929	Identity:	210/929 - (22%)
Similarity:	385/929 - (41%)	Gaps:	208/929 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 DDDNNSAAHSSDSKSPSQR-------KSRIGDGASDPDSDWTRSNQRWMKLRTTVQISSAIQKKP 181
            :::...||.:.::.:|::.       ::|...|.....:...:..|....|:.||...|
Mouse     2 EEEARPAAGAGEAATPARETPPAAPAQARAASGGVPESAPEPKRRQLGTLLQPTVNKFS------ 60

  Fly   182 PLKREDSFLKRFSTRQIPE-TQETVEDTGSESASGDVDKSVKRRRRYLQKRRSVVNPDENFYFYW 245
                    |:.|.:.:..| .||.|:..|:                      .:::|..:|.|||
Mouse    61 --------LRVFGSHKAVEIEQERVKSAGA----------------------WIIHPYSDFRFYW 95

  Fly   246 LMMLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTG-YLEQGL-MVY 308
            .:::.:.::.||..|.|..:|.:.:.|.|  |::.:.::|..|:||:::..||| .:|:|. ::.
Mouse    96 DLIMLLLMVGNLIVLPVGITFFKEENSPP--WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILL 158

  Fly   309 DDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGTHP--------------LLRFTRFFKVYRSVR 359
            ..|.:...|:.:. |:.|:|:.||:|.:.|.:...|              ::|||:...:.|.:|
Mouse   159 APRAIRTRYLRTW-FLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLR 222

  Fly   360 FYYIVESRTVWPNLW-----------RVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYPYR 412
            ...::.....|..::           |:.|||.::|:|.||.||..||:...:.|..| ||...|
Mouse   223 LSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVSMNR 287

  Fly   413 PGDYATLTRKYLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITN 476
            ..:: :..|:|..:|:.:...:..|| ....|....:...|::|.::|...:|..:|....:|.:
Mouse   288 MVNH-SWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQS 351

  Fly   477 RNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGG-GDINTALGLLPDKLKT 540
            .:::|.:::......:.||..||:|...::|:..:|::     |.||. .|..:.||.|.:.|:.
Mouse   352 LDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEH-----RYQGKMFDEESILGELSEPLRE 411

  Fly   541 ELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLS 605
            |:.......::..:.:|....|.|:..::.|::..:|.|||.:.|:|.|.|:|:.|..|:|.||:
Mouse   412 EIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLA 476

  Fly   606 ETGKVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQT 670
            . |...|.:..|.:||||.:|.   ..:|||.||:..|..|:|||.:...|.::::|..:...:|
Mouse   477 R-GARDTRLTDGSYFGEICLLT---RGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFET 537

  Fly   671 LGRKRLMEVRCVNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKL-KH 734
            :...||   |.:.||.:..|..:                       |:.|..|:...:...| :|
Mouse   538 VAMDRL---RRIGKKNSILQRKR-----------------------SEPSPGSSGGVMEQHLVQH 576

  Fly   735 D---VKGFRNVLKKSRTSRKSDESLEMQPLHNTSPRGSKILLKRMSRVRSDEKDADSAEAKDELH 796
            |   .:|.|. |.....:|.|.:.:..:||.:...:.:.:               .|..|....|
Mouse   577 DRDMARGVRG-LAPGTGARLSGKPVLWEPLVHAPLQAAAV---------------TSNVAIALTH 625

  Fly   797 DKTPSPIGAGLP--LLQRLRLLKEKQDREERAVKSTPPQKSPPHSHVTCTLSPQESIQEEPEREF 859
            .:.|.|:....|  ||.|            .|.:|.....||        |.|..:
Mouse   626 QRGPLPLSPDSPATLLAR------------SARRSAGSPASP--------LVPVRA--------- 661

  Fly   860 SEGFPLIQRLQQLKIKNEPQANAAEPGVVMVNTPPNISSKIDSHFAASQAGASH-----PGPNGG 919
               .||:.|        .|.|:.:.     :..||..:    .|.:.|:.|.|.     |.|.||
Mouse   662 ---GPLLAR--------GPWASTSR-----LPAPPART----LHASLSRTGRSQVSLLGPPPGGG 706

  Fly   920 AIGISAPGQSLTVAQIKPIMKVSFKQKIQQMQGGGG----GASSSPGPSTGAIAKK----EPPKS 976
            |..:...|:.|:.:|  |.:.       |:..|.|.    |:.|...|.:|.:||.    :||:|
Mouse   707 ARRLGPRGRPLSASQ--PSLP-------QRATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPPRS 762

  Fly   977 LALVAKHATSEDPVAAAGL 995
              .|.:..|...|..:|.:
Mouse   763 --SVPEPVTPRGPQISANM 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	60/249 (24%)
		Ion_trans_2	382..476	CDD:285168	25/95 (26%)
		Crp	550..>680	CDD:223736	41/129 (32%)
		CAP_ED	556..668	CDD:237999	38/111 (34%)
Hcn3	NP_032253.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		5/44 (11%)
		Involved in subunit assembly. /evidence=ECO:0000250	45..90		13/80 (16%)
		Ion_trans_N	48..90	CDD:312050	12/77 (16%)
		Ion_trans	92..357	CDD:306908	65/268 (24%)
		Interaction with KCTD3. /evidence=ECO:0000269\|PubMed:23382386	353..779		126/536 (24%)
		CAP_ED	427..535	CDD:237999	38/111 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..569		5/42 (12%)
		Atrophin-1	<585..773	CDD:331285	55/263 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..779		28/102 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835111
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3583
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.890