DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and Hcn2

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_032252.1	Gene:	Hcn2 / 15166	MGIID:	1298210	Length:	863	Species:	Mus musculus

Alignment Length:	971	Identity:	205/971 - (21%)
Similarity:	380/971 - (39%)	Gaps:	261/971 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 GGGAGGAGGSGGAGGHSDGGYHKRHHHKMVRDDDNNSAAHSSDSKSPSQRKSRIGDGASDPDSDW 157
            |...|||.|..|.|                    ....:....::.|....|..| .||.|
Mouse    72 GAAKGGANGECGRG--------------------EPQCSPEGPARGPKVSFSCRG-AASGP---- 111

  Fly   158 TRSNQRWMKLRTTVQISSAIQKKP---PLKREDSFLKR------------FSTRQIPETQETVED 207
                       :..:.:.:.:..|   |...:.|||:|            ||.|..
Mouse   112 -----------SAAEEAGSEEAGPAGEPRGSQASFLQRQFGALLQPGVNKFSLRMF--------- 156

  Fly   208 TGSESASGDVDKSVKRRRRYLQKRRS-VVNPDENFYFYWLMMLTVCVLYNLWTLIVRQSFPELQQ 271
             ||:       |:|:|.:..::...: :::|..:|.|||...:.:.::.||..:.|..:|.:.:.
Mouse   157 -GSQ-------KAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDET 213

  Fly   272 SVPTFWLICDSMTDVVFILDIIVQLRTGYL--EQGLMVYDDRKLACHYVHSRDFIFDMIALIPLD 334
            :.|  |::.:.::|..|::|:::..|||.:  :...::.|..|:...|:.:. |:.|.::.||:|
Mouse   214 TAP--WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTW-FVVDFVSSIPVD 275

  Fly   335 --LLQLKMGTHP----------LLRFTRFFKVYRSVRFYYIVESRTVWPNLW-----------RV 376
              .|.::.|...          ::|||:...:.|.:|...::.....|..::           |:
Mouse   276 YIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRI 340

  Fly   377 VNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYPYRPGDYATLTRKYLGSLYWSTLTLTTIG-D 439
            .|||.::|:|.||.||..||:...:.|..| ||......:: :.:..|..:|:.:...:..|| .
Mouse   341 CNLISMMLLLCHWDGCLQFLVPMLQDFPSDCWVSINNMVNH-SWSELYSFALFKAMSHMLCIGYG 404

  Fly   440 LPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGM 504
            ...||:..:...|::|.::|...:|..:|....:|.:.:::|.:::......:.||..||:|...
Mouse   405 RQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADF 469

  Fly   505 KRRVLRWYDYSWSRGRIQGG-GDINTALGLLPDKLKTELALHVNLSVLKKVT---IFQECQPEFL 565
            ::::..:|::     |.||. .|.::.||.|...|:.|:   ||.:..|.|.   :|....|.|:
Mouse   470 RQKIHDYYEH-----RYQGKMFDEDSILGELNGPLREEI---VNFNCRKLVASMPLFANADPNFV 526

  Fly   566 HDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFGEIGILNLDG 630
            ..::.|:|..:|.|||.|.|:|.:.::|:.|..|::.||::..|.: .:..|.:||||.:|.
Mouse   527 TAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEM-KLSDGSYFGEICLLT--- 587

  Fly   631 LNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCVNKKYA----KAQS 691
            ..:|||.||:..|..|:|||.::....:::||..:...:|:...||..   :.||.:    |.|.
Mouse   588 RGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDR---IGKKNSILLHKVQH 649

  Fly   692 DKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDVKGFRNVLKKSRTSRK----- 751
            |..:..:                   ::.||:..::||   |:|    |.:::::...::
Mouse   650 DLSSGVF-------------------NNQENAIIQEIV---KYD----REMVQQAELGQRVGLFP 688

  Fly   752 ---------SDESLEMQPLHNTSPRGSKILLKRMSRVRSDEKDADSAEAKDELHDKTPSPIGAGL 807
                     :..:|:.....:..|:.::.|:                           .|:..|.
Mouse   689 PPPPPQVTSAIATLQQAVAMSFCPQVARPLV---------------------------GPLALGS 726

  Fly   808 PLLQRLRLLKEKQDREERAVKSTPPQKSPPHSHVTCTLSPQESIQEEPEREFSEGFPLIQRLQQL 872
            |                |.|:..||...||      ..||.......|....|   |...|....
Mouse   727 P----------------RLVRRAPPGPLPP------AASPGPPAASPPAAPSS---PRAPRTSPY 766

  Fly   873 KIKNEPQANAAEPGVVMVNTPPNISSKIDSHFAASQAGASHPGPNGGAIGISAPGQSLTVAQIKP 937
            .:...| |....|.:     |....|:.....:|||....|        |:.||..:   |..:|
Mouse   767 GVPGSP-ATRVGPAL-----PARRLSRASRPLSASQPSLPH--------GVPAPSPA---ASARP 814

  Fly   938 IMKVSFKQKIQQMQGGGGGASSSP--GPS-TGAIAKKEPPKSLALVAKHATSEDPVAAAGL 995
                              .:||:|  ||: |...|...|.:        ..|..|.||:||
Mouse   815 ------------------ASSSTPRLGPAPTARTAAPSPDR--------RDSASPGAASGL 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	54/247 (22%)
		Ion_trans_2	382..476	CDD:285168	24/95 (25%)
		Crp	550..>680	CDD:223736	41/132 (31%)
		CAP_ED	556..668	CDD:237999	36/111 (32%)
Hcn2	NP_032252.1	CAP_ED	517..625	CDD:237999	36/111 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..863		39/172 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..131		15/94 (16%)
		Involved in subunit assembly	131..182		13/67 (19%)
		Ion_trans_N	140..182	CDD:285597	9/58 (16%)
		Ion_trans	202..447	CDD:278921	54/248 (22%)
		Crp	511..>646	CDD:223736	42/141 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3583
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960