Protein Alignment Cngl and KCNH8

DIOPT Version :10

• Sequence 1: NP_727848.3
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: XP_016861187.1
• Gene: KCNH8 / 131096
• HGNCID: 18864
• Length: 1108
• Species: Homo sapiens
• Alignment Length: 1275
• Identity: 259/1275 - (20%)
• Similarity: 464/1275 - (36%)
• Gaps: 377/1275 - (29%)

  Fly   160 SNQRWMKLRTTVQISSAIQKKPPLKREDSFLKR-------------------------FSTRQIP 199
            :|::.|     :||..::::|...|.|..|.|:                         .|.:.|.
Human    75 TNEQLM-----LQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVVLFLASFKDIT 134

  Fly   200 ETQE--TVEDTGSE-----SASGDVDKSVKRRRR--------YLQKR-RSVVNPDENFY------ 242
            :|:.  |.||...:     |.:|....|.:||.|        :||:| ::.:..:.|.:
Human   135 DTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAF 199

  Fly   243 ------------------------FYWLMML-----TVCVLYNLWTLIVRQSFPELQQSVPTFWL 278
                                    :.||::|     .|.|.||:..:    ...:|..:..|  .
Human   200 PEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFI----GNDDLSTTRST--T 258

  Fly   279 ICDSMTDVVFILDIIVQLRTGYL-EQGLMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGT 342
            :.|...:::||:|||:..||.|: :.|.::::.|.:..||| :..||.|:||.:|.|||.....|
Human   259 VSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYV-TTWFIIDLIAALPFDLLYAFNVT 322

  Fly   343 HPLLRFTRFFKVYRSVRFYYIVESRTVWPNLWRVV--NLIHILLILAHWFGCFYFLLSEAE---- 401
              ::......|..|.:|...:::....:.....:|  .|:.:..:||||..|.::::.:.|
Human   323 --VVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDN 385

  Fly   402 ---GFQGDWVY--------PYRPGDY---ATLTRKYLGSLYWSTLTLTTIG-DLPTPETNAEPNF 451
               .::..|::        ||...:.   .::...|:.:||::..:||::| ...:..|:||.
Human   386 SLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEK-- 448

  Fly   452 SVDGPRSIPRRGIKSRLLQFGSSYGYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLL 516
                                      ||:|.:.|||..:.|.:.|.|..:|....:....:....
Human   449 --------------------------IFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRT 487

  Fly   517 DGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKK 581
            ...|.::|.|.:|..:|:|:|.::..:||   :..|.|.|..|...||:|::::.:|:|..:| :
Human   488 KDLKDFIRVHHLPQQLKQRMLEYFQTTWS---VNNGIDSNELLKDFPDELRSDITMHLNKEIL-Q 548

  Fly   582 VTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGD 646
            :::|:......|..|.|.:|.....||:.:.|:|:..:.::.:..|.:|||.:: .||..:..||
Human   549 LSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDS-MVLAILGKGD 612

  Fly   647 FFGEIGILNL---DGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVR 708
            ..|    .||   |.:.|..|||:::.|.:                      ||.:..|.|.||.
Human   613 LIG----ANLSIKDQVIKTNADVKALTYCD----------------------LQCIILKGLFEVL 651

  Fly   709 CVNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDVK-GFRNVLK 772
            .:..:||                                      .|.|:.::||:. ..|...:
Human   652 DLYPEYA--------------------------------------HKFVEDIQHDLTYNLREGHE 678

  Fly   773 KSRTSRKSDESLEMQPLHNTSPRGSKILLKRMSRVRSDEKDADSAEAKDELHDKTPSPI------ 831
            ....||.|::|:..|    :.|:|:..:.||:..:..||::.:..|.::.:   :.|||
Human   679 SDVISRLSNKSMVSQ----SEPKGNGNINKRLPSIVEDEEEEEEGEEEEAV---SLSPICTRGSS 736

  Fly   832 ------GAGLPLLQRLRLLKEKQESIQEEPEREFSEGFPL-IQRLQQLKIKNEPQANAAEPGVVM 889
                  |:....|.    |..||.:....|...     |: :.|....|.|.|..
Human   737 SRNKKVGSNKAYLG----LSLKQLASGTVPFHS-----PIRVSRSNSPKTKQEID---------- 782

  Fly   890 VNTPPNISSKIDSHFAASQAGASHPGPNGGAIGISAPGQSLTVAQIKPIMKVSFKQKIQQMQGGG 954
               |||.:.:.:.:.....:..::.||           ..|:.::|           :..::.|.
Human   783 ---PPNHNKRKEKNLKLQLSTLNNAGP-----------PDLSPSRI-----------VDGIEDGN 822

  Fly   955 GGASSSPGPSTGAIAKKEPPKSLALVAKHATSEDPVAAAGLGLGSGSSSGIATISKRVVKPQSHR 1019
            ....|..........:.||..|..|       .||...|          .:..|.....|.|.::
Human   823 SSEESQTFDFGSERIRSEPRISPPL-------GDPEIGA----------AVLFIKAEETKQQINK 870

  Fly  1020 MATPLQSDTDTDGTPIKPWSKLKLATLMSSSYTSLTNCSPDDLASPLKN--YSLSNI--PQQ--- 1077
                                       ::|..|:||. ....|...::|  ..|.|:  |||
Human   871 ---------------------------LNSEVTTLTQ-EVSQLGKDMRNVIQLLENVLSPQQPSR 907

  Fly  1078 -MESHTR---PRHHSARSSSRSPRHGHHHHHHHGHHQHGQLQGPSSTCTNGSTTSQVNQVTASAK 1138
             ...|:.   |...|.::.:....|....|...|...:.|.|..||..|:...:...:.|.:|.:
Human   908 FCSLHSTSVCPSRESLQTRTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWSVDPSSVGSSPQ 972

  Fly  1139 RDCLRLQKPEQHLPDGELTELGGNGRRKLYQS-VFDLSPEYCGLPFVKRLKIL-----NERQKLA 1197
            |.....|.|    .|.|           ||.| ..|.||.:..:.....|:.|     :....|.
Human   973 RTGAHEQNP----ADSE-----------LYHSPSLDYSPSHYQVVQEGHLQFLRCISPHSDSTLT 1022

  Fly  1198 ELERALQTRSFSLDCSKSGPDSKVPITESLYRCYSDTS--GIYSQFLSTYESTTSSTSISTNTSA 1260
            .|:....|.|.|: ||.|        ..||:......|  |.:||      .|.||.|:. |...
Human  1023 PLQSISATLSSSV-CSSS--------ETSLHLVLPSRSEEGSFSQ------GTVSSFSLE-NLPG 1071

  Fly  1261 SASASASASASASDSNSRQLQYVPLPLSPESNETMERRKL 1300
            |.:....||||     ::.|:.:||.:...:.|..:.:.:
Human  1072 SWNQEGMASAS-----TKPLENLPLEVVTSTAEVKDNKAI 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_727848.3	Ion_trans	240..509	CDD:459842	67/325 (21%)
		CAP_ED	584..696	CDD:237999	26/114 (23%)
		dermokine	<1688..>1775	CDD:455732
KCNH8	XP_016861187.1	PAS_9	40..135	CDD:463873	11/64 (17%)
		PLN03192	175..>615	CDD:215625	106/481 (22%)
		PRK11753	578..>656	CDD:236969	25/104 (24%)