Protein Alignment Cngl and CNGA3

DIOPT Version :9

• Sequence 1: NP_001245691.1
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: XP_011508856.1
• Gene: CNGA3 / 1261
• HGNCID: 2150
• Length: 749
• Species: Homo sapiens
• Alignment Length: 789
• Identity: 262/789 - (33%)
• Similarity: 408/789 - (51%)
• Gaps: 121/789 - (15%)

  Fly     5 VSAYRAHAS-AHKKILSSGYHSQLNYGSTGAAAASSSSSGATAT-----GLYTMEAHEHEAGKFV 63
            ::...:|.| .|.|:.:|  ...||....|.:.|.|||...::.     .:.|....:...|.|.
Human     4 INTQYSHPSRTHLKVKTS--DRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQGSFT 66

  Fly    64 -KDVAR--QVHDCNSDTDVI--SPTGTSISG-------GGGGGGAGGAGGSGGAGGHSDGGYHK- 115
             :.:||  ::...:....|:  :..|..:.|       .||........||.|......|...:
Human    67 GQGIARFGRIQKKSQPEKVVRAASRGRPLIGWTQWCAEDGGDESEMALAGSPGCSSGPQGRLSRL 131

  Fly   116 ---------RH-HHKMVRDDDNNSAAHSSDSKSPSQRKS--RIGDGASDPDSDWTRSNQRWMKLR 168
                     || ||:....|........::.|..|.::|  :...|:.:|..   |....|...:
Human   132 IFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQANVGSQEPAD---RGRSAWPLAK 193

  Fly   169 TTVQISSAIQKKPPLKREDSFLKRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKRRS 233
            .....|:..:::...|::|:.
Human   194 CNTNTSNNTEEEKKTKKKDAI-------------------------------------------- 214

  Fly   234 VVNPDENFYFYWLMMLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRT 298
            ||:|..|.|:.||..:.:.|.||.:.||.|..|.|||......||:.|...||:::||::|:.||
Human   215 VVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLVRART 279

  Fly   299 GYLEQGLMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGT-HPLLRFTRFFKVYRSVRFYY 362
            |:|||||||.|..:|..||..:..|..|:::|:|.||..||:|| :|.:||.|..|..|...|:.
Human   280 GFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFD 344

  Fly   363 IVESRTVWPNLWRVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYP-YRPGDYATLTRKYLG 425
            ..|:||.:||::|:.||:..:||:.||..|.||.:|:..||..| |||| ....::..|:|||:.
Human   345 RTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIY 409

  Fly   426 SLYWSTLTLTTIGDLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDG 490
            |||||||||||||:.|.|..:.||:|.:|.:|:||.|||||||.||::|:|.||:|.||:..:|.
Human   410 SLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDS 474

  Fly   491 AKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVT 555
            .|.||:..||...::.||:||:||.|:..:..   |....|..||||||.|:|::|:|..||||.
Human   475 IKQYMQFRKVTKDLETRVIRWFDYLWANKKTV---DEKEVLKSLPDKLKAEIAINVHLDTLKKVR 536

  Fly   556 IFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKV-LTTMKAGDF 619
            |||:|:...|.:||||::..:|:|||.||:||::.:||:||.:|.|.|:::.|.. ...:..|.:
Human   537 IFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSY 601

  Fly   620 FGEIGILNLDGL---NKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRC 681
            ||||.|||:.|.   |:|||::||:|||:||.||::|::.|:.:||:|::.|:..||:.||:...
Human   602 FGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNL 666

  Fly   682 VNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSS-------------ENSAS----KKIV 729
            ::::.|:|.:|.:..              :.:|.|..||             |.:|:    |:.:
Human   667 IDEELARAGADPKDL--------------EEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRL 717

  Fly   730 DKLKHDVKG 738
            .:|:..|||
Human   718 SQLESQVKG 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	108/223 (48%)
		Ion_trans_2	382..476	CDD:285168	51/95 (54%)
		Crp	550..>680	CDD:223736	61/133 (46%)
		CAP_ED	556..668	CDD:237999	52/115 (45%)
CNGA3	XP_011508856.1	Ion_trans	241..465	CDD:278921	108/223 (48%)
		Crp	531..>701	CDD:223736	68/183 (37%)
		CAP_ED	537..653	CDD:237999	52/115 (45%)
		CLZ	653..723	CDD:293134	16/83 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145031
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850