DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cngl and CNGA2

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_005131.1	Gene:	CNGA2 / 1260	HGNCID:	2149	Length:	664	Species:	Homo sapiens

Alignment Length:	589	Identity:	234/589 - (39%)
Similarity:	352/589 - (59%)	Gaps:	49/589 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 AGGHSDGGYHKRHHHKMVRDDDNNSAAHS-SDSKSPSQRKS-------RIGDGASDPDSDWTRSN 161
            |.|..|.....|.|  ...|||.:|.... :|..:|.|.:|       .:|     ...:|...|
Human    26 ANGKDDHRTSSRPH--SAADDDTSSELQRLADVDAPQQGRSGFRRIVRLVG-----IIREWANKN 83

  Fly   162 QRWMKLRTTVQISSAIQKKPPLKREDSFLKRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRR 226
            .|              :::|   |.||||:||...:: :|..|.|..|.....|: ||..|::..
Human    84 FR--------------EEEP---RPDSFLERFRGPEL-QTVTTQEGDGKGDKDGE-DKGTKKKFE 129

  Fly   227 YLQKRRSVVNPDENFYFYWLMMLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILD 291
            ..     |::|..::|:.||.::.:.||||...|:.|..|.:||:.....||:.|.::|||:|.|
Human   130 LF-----VLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIAD 189

  Fly   292 IIVQLRTGYLEQGLMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGTH-PLLRFTRFFKVY 355
            :.::||||:|||||:|.|.:||..:|:|:..|..|:.::||.||:...:..| |.:||.|.....
Human   190 LFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFA 254

  Fly   356 RSVRFYYIVESRTVWPNLWRVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYP-YRPGDYAT 418
            |...|:...|:||.:||::|:.||:..:|::.||..|.|:.:|::.||..| |||| ....:|..
Human   255 RMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGY 319

  Fly   419 LTRKYLGSLYWSTLTLTTIGDLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLE 483
            |.|:|:..||||||||||||:.|.|..:.||:|.|..:||||.|||||||.||::|:|.||.|.|
Human   320 LAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAE 384

  Fly   484 FERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNL 548
            |:..:|..|.||:..||..||:.:|:||:||.|:..:..   |....|..||.||:.|:|::|:|
Human   385 FQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTV---DEREILKNLPAKLRAEIAINVHL 446

  Fly   549 SVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKV-LT 612
            |.||||.||.:|:...|.:||||::..:|:|||.|||||::.:||:||.:|.|.|:::.|.. ..
Human   447 STLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYA 511

  Fly   613 TMKAGDFFGEIGILNLDGL---NKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRK 674
            .:.||..||||.|||:.|.   |:|||::||:|||:||.||::|::.|:.:||||:::|:..||:
Human   512 LLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGRE 576

  Fly   675 RLME 678
            .||:
Human   577 ILMK 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	101/223 (45%)
		Ion_trans_2	382..476	CDD:285168	49/95 (52%)
		Crp	550..>680	CDD:223736	63/133 (47%)
		CAP_ED	556..668	CDD:237999	54/115 (47%)
CNGA2	NP_005131.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		8/24 (33%)
		Ion_trans	174..382	CDD:278921	96/207 (46%)
		Radical_SAM	415..>468	CDD:302752	22/55 (40%)
		Crp	448..632	CDD:223736	63/133 (47%)
		CAP_ED	454..570	CDD:237999	54/115 (47%)
		CLZ	570..639	CDD:293134	5/11 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	641..664
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820