Protein Alignment Cngl and CNGA1

DIOPT Version :9

• Sequence 1: NP_001245691.1
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: XP_005248106.2
• Gene: CNGA1 / 1259
• HGNCID: 2148
• Length: 765
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 227/592 - (38%)
• Similarity: 355/592 - (59%)
• Gaps: 40/592 - (6%)

  Fly   124 DDDNNSAAHSSDSKSPSQR-----KSRIGDGASDPDSDWTRSNQRWMKLRTTVQI-----SSAIQ 178
            |||:.|.:..|::::|..|     ||....|.|          ||...|...:.:     ||...
Human   120 DDDSASTSEESENENPHARGSFSYKSLRKGGPS----------QREQYLPGAIALFNVNNSSNKD 174

  Fly   179 KKPPLKREDSFLKRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKRRS-----VVNPD 238
            ::|..|::.   |:....:..:..|...|...:....|.:|..|..:...:|...     |::|.
Human   175 QEPEEKKKK---KKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKKEVVVIDPS 236

  Fly   239 ENFYFYWLMMLTVCVLYNLWTLIV-RQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYLE 302
            .|.|:.||..:|:.|:|| ||::: |..|.|||.....:|||.|.::|:|:::|:.|:.||||||
Human   237 GNTYYNWLFCITLPVMYN-WTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLE 300

  Fly   303 QGLMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMG-THPLLRFTRFFKVYRSVRFYYIVES 366
            |||:|.::.||...|..:..|..|:::|||.|||..|:| .:|.:|..|..:..|...|:...|:
Human   301 QGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFFQRTET 365

  Fly   367 RTVWPNLWRVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYP-YRPGDYATLTRKYLGSLYW 429
            ||.:||::|:.||:..::|:.||..|.::.:|:|.||..| |||| ....::..|.|||:.||||
Human   366 RTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYW 430

  Fly   430 STLTLTTIGDLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTY 494
            |||||||||:.|.|..::||:|.:|.:||||.|||||||.:|::|:|.||.|.||:..:|..|.|
Human   431 STLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQY 495

  Fly   495 MRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQE 559
            |....|...|::||::|:||.|:..:..   |....|..|||||:.|:|::|:|..||||.||.:
Human   496 MHFRNVSKDMEKRVIKWFDYLWTNKKTV---DEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFAD 557

  Fly   560 CQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKV-LTTMKAGDFFGEI 623
            |:...|.:||||::..:::|||.||:||::.|||:||.:|.|.|:::.|.. ...:..|.:||||
Human   558 CEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEI 622

  Fly   624 GILNLDGL---NKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCVNKK 685
            .|||:.|.   |:|||:::|:|||:||.||::|::.|:.:||||:.:|:..|::.||:...::..
Human   623 SILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLN 687

  Fly   686 YAKAQSD 692
            .|.|.||
Human   688 IANAGSD 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	101/224 (45%)
		Ion_trans_2	382..476	CDD:285168	49/95 (52%)
		Crp	550..>680	CDD:223736	59/133 (44%)
		CAP_ED	556..668	CDD:237999	51/115 (44%)
CNGA1	XP_005248106.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145049
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750