DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and CNGB1

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_001288.3	Gene:	CNGB1 / 1258	HGNCID:	2151	Length:	1251	Species:	Homo sapiens

Alignment Length:	958	Identity:	243/958 - (25%)
Similarity:	390/958 - (40%)	Gaps:	246/958 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 AAASSSSSGATATGLYTMEAHEHEAGKFVKDVARQVHDCNSD-----------TDVISP-----T 83
            |.|.::|||..||     :.|...          ||.|.::|           :.|:.|     :
Human   449 AEAEAASSGVPAT-----KQHPEV----------QVEDTDADSCPLMAEENPPSTVLPPPSPAKS 498

  Fly    84 GTSISGGGGGGGAGGAGGSGGAGGHSDGGYHKRHHHKMVRDDDNN------SAAHS-----SDSK 137
            .|.|......|                     .|..|:..:||..      |.|.|     ||..
Human   499 DTLIVPSSASG---------------------THRKKLPSEDDEAEELKALSPAESPVVAWSDPT 542

  Fly   138 SPSQRKSRIGDG----ASDPDSDWTRSNQRWMKL-RTTVQISSAIQKK---PPLKREDSFLKRFS 194
            :|...     ||    ||...::....|.|..:| :...:.:..:::|   |.:..::...|...
Human   543 TPKDT-----DGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSP 602

  Fly   195 TRQIPETQETVEDTGSESASGD--VDK-SVKRRRRYLQKRR--SVVNPDEN-FYFYWLMMLTVCV 253
            .::.||.....:...:|....:  .|. ..|.:.|..:|.:  ..::|..| .|..||..:.:..
Human   603 AKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWLFFVVMAW 667

  Fly   254 LYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIV-QLRTGYLEQGLMVYDDRKLACHY 317
            .:|.|.:.||.:||.........||:.|.:.|:::.|||.| |.|..::..|.::.|.:.:..:|
Human   668 NWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNY 732

  Fly   318 VHSRDFIFDMIALIPLDLLQLKMGTHPLLRFTRFFKVYRSVRFYYIVESRTVWPNLWRVVNLIHI 382
            :.||.|..|:::|:|||.|.||:|.:||||..|..|......|...:||......::||:.....
Human   733 LKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAY 797

  Fly   383 LLILAHWFGCFYFLLSEAEGF-QGDWVYPYRPGDYATLTRKYLGSLYWSTLTLTTIGDLPTPETN 446
            ||...|...|.|:..|..:|. ...|||.       .:...|:...|::..||.|||.||.|:|.
Human   798 LLYSLHLNSCLYYWASAYQGLGSTHWVYD-------GVGNSYIRCYYFAVKTLITIGGLPDPKTL 855

  Fly   447 AEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRW 511
            .|.:|.:::|..|||.|:.::||:.:|:....|.:..:...:|....||..:|:|..::.||..|
Human   856 FEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTW 920

  Fly   512 YDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYI 576
            |:|:|   ..||..|.:..:..||||::.:||:.||.:::.||.:||.|..:.:.|::.::::.:
Human   921 YEYTW---HSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVV 982

  Fly   577 FTPGDSICRKGEVAREMFIIADGILEVL-SETGK-VLTTMKAGDFFGEIGILNLDGLNKRTADVR 639
            :.|.|.:|:|||:.|||:||..|.::|| ...|| ||.|:|||..||||.:|.:.|.|:|||:|.
Human   983 YLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRTANVV 1047

  Fly   640 SVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCVNK-------------------- 684
            :.|::.||.|.::|:...:..||::|::|:...|:.|   |..||
Human  1048 AHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRML---RSNNKPKEEKSVLILPPRAGTPKLF 1109

  Fly   685 ------------------KYAKAQSD-KEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVD 730
                              |.|..::. ||.||..||      :..|..|.|:.||:
Human  1110 NAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAA------AKQQELVEQAKSSQ--------- 1159

  Fly   731 KLKHDVKGFRNVLKKSRTSRKSDESLEMQPLHNTSPRGSKILLKRMSRVRSDEKDADSAEAKDEL 795
                ||||               |.....|..:|.|:                          |.
Human  1160 ----DVKG---------------EEGSAAPDQHTHPK--------------------------EA 1179

  Fly   796 HDKTPSPIGAGLPLLQRLRLLKEKQDREERAVKSTPPQK--SPPHSHVTCTLSPQESIQE---EP 855
            ....|:|                          .|||:.  |||.|....:|...|..:|   ||
Human  1180 ATDPPAP--------------------------RTPPEPPGSPPSSPPPASLGRPEGEEEGPAEP 1218

  Fly   856 EREFSEGFPLIQRLQQLKIKNEPQANAAEPG--VVMVNTPPNISSKID 901
            |.            ..::|...|   ..|||  ::.|..|.....|.:
Human  1219 EE------------HSVRICMSP---GPEPGEQILSVKMPEEREEKAE 1251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	72/222 (32%)
		Ion_trans_2	382..476	CDD:285168	31/94 (33%)
		Crp	550..>680	CDD:223736	50/131 (38%)
		CAP_ED	556..668	CDD:237999	45/113 (40%)
CNGB1	NP_001288.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..151
		Trypan_PARP	<171..257	CDD:114603
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..252
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..561		31/152 (20%)
		IQ-like	568..578		1/9 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..619		5/33 (15%)
		Ion_trans	674..881	CDD:278921	70/213 (33%)
		Crp	956..>1093	CDD:223736	53/139 (38%)
		CAP_ED	962..1071	CDD:237999	43/108 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1151..1251		36/194 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850