DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cngl and Hcn3

DIOPT Version :10

Sequence 1:NP_727848.3 Gene:Cngl / 32468 FlyBaseID:FBgn0263257 Length:1970 Species:Drosophila melanogaster
Sequence 2:NP_446137.1 Gene:Hcn3 / 114245 RGDID:620691 Length:780 Species:Rattus norvegicus


Alignment Length:931 Identity:204/931 - (21%)
Similarity:381/931 - (40%) Gaps:216/931 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 VRDDDNNSAAHSSDSKSPSQRKSRIG---DGASDPDSDWTRSNQRWMKLRTTVQISSAIQKKPPL 183
            |.|.:..:.|..:...:|:|.::..|   :.|.:|     :..|....|:.||...|        
  Rat     9 VGDGEAATPARETPPAAPAQARAASGGVPESAPEP-----KRRQLGTLLQPTVNKFS-------- 60

  Fly   184 KREDSFLKRFSTRQIPE-TQETVEDTGSESASGDVDKSVKRRRRYLQKRRSVVNPDENFYFYWLM 247
                  |:.|.:.:..| .||.|:..|:                      .:::|..:|.|||.:
  Rat    61 ------LRVFGSHKAVEIEQERVKSAGA----------------------WIIHPYSDFRFYWDL 97

  Fly   248 MLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTG-YLEQGL-MVYDD 310
            ::.:.::.||..|.|..:|.:.:.|.|  |::.:.::|..|:||:::..||| .:|:|. ::...
  Rat    98 IMLLLMVGNLIVLPVGITFFKEENSPP--WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAP 160

  Fly   311 RKLACHYVHSRDFIFDMIALIPLDLLQLKMGTHP--------------LLRFTRFFKVYRSVRFY 361
            |.:...|:.:. |:.|:|:.||:|.:.|.:...|              ::|||:...:.|.:|..
  Rat   161 RAIRTRYLRTW-FLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLS 224

  Fly   362 YIVESRTVWPNLW-----------RVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYPYRPG 414
            .::.....|..::           |:.|||.::|:|.||.||..||:...:.|..| ||...|..
  Rat   225 RLIRYMHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVSMNRMV 289

  Fly   415 DYATLTRKYLGSLYWSTLTLTTIGDLPTPETNAEPNFSVDGPRSIPRRGIKSRLLQFGSSYGYIF 479
            :: :..|:|..:|:.:...:..||            :....|..:|               ....
  Rat   290 NH-SWGRQYSHALFKAMSHMLCIG------------YGQQAPVGMP---------------DVWL 326

  Fly   480 TIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSW 544
            |::|.::|...:|..:|....:|.:.:::|.:::......:.||..||:|...::|:..:|::  
  Rat   327 TMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEH-- 389

  Fly   545 SRGRIQGG-GDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPG 608
               |.||. .|..:.||.|.:.|:.|:.......::..:.:|....|.|:..::.|::..:|.||
  Rat   390 ---RYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPG 451

  Fly   609 DSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSE 673
            |.:.|:|.|.|:|:.|..|:|.||:. |...|.:..|.:||||.:|.   ..:|||.||:..|..
  Rat   452 DLVVREGSVGRKMYFIQHGLLSVLAR-GARDTRLTDGSYFGEICLLT---RGRRTASVRADTYCR 512

  Fly   674 LFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCVNKKYAKAQSDKEAAAYAAAHPHHHQSHH 738
            |:|||.:...|.::::|..:...:|:...||   |.:.||.:..|..:                 
  Rat   513 LYSLSVDHFNAVLEEFPMMRRAFETVAMDRL---RRIGKKNSILQRKR----------------- 557

  Fly   739 QGQVHQSDSSENSASKKIVDK--LKHD---VKGFRNVLKKSRTSRKSDESLEMQPLHNTSPRGSK 798
                  |:.|..|:|..::::  ::||   .:|.|. |.....:|.|.:.:..:||.:...:.:.
  Rat   558 ------SEPSPGSSSGGVMEQHLVQHDRDMARGIRG-LAPGTGARLSGKPVLWEPLVHAPLQAAA 615

  Fly   799 ILLKRMSRVRSDEKDADSAEAKDELHDKTPSPIGAGLPLLQRLRLLKEKQESIQEEPEREFSEGF 863
            :               .|..|....|.:.|.|:....|.....|..:....          |...
  Rat   616 V---------------TSNVAIALTHQRGPLPLSPDSPATLLARSARRSAG----------SPAS 655

  Fly   864 PLIQRLQQLKIKNEPQANAAEPGVVMVNTPPNISSKIDS------HFAASQAGASH-----PGPN 917
            ||:               ....|.::...|...:|::.:      |.:.|:.|.|.     |.|.
  Rat   656 PLV---------------PVRAGPLLARGPWASTSRLPAPPARTLHASLSRTGRSQVSLLGPPPG 705

  Fly   918 GGAIGISAPGQSLTVAQIKPIMKVSFKQKIQQMQGGGG----GASSSPGPSTGAIAKKEPP---- 974
            ||...:...|:.|:.:|  |.:.       |:..|.|.    |:.|...|.:|.:||  ||    
  Rat   706 GGGRRLGPRGRPLSASQ--PSLP-------QRATGDGSPRRKGSGSERLPPSGLLAK--PPGTVQ 759

  Fly   975 KSLALVAKHATSEDPVAAAGL 995
            .|.:.|.:..|...|..:|.:
  Rat   760 PSRSSVPEPVTPRGPQISANM 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CnglNP_727848.3 Ion_trans 240..509 CDD:459842 67/296 (23%)
CAP_ED 584..696 CDD:237999 38/111 (34%)
dermokine <1688..>1775 CDD:455732
Hcn3NP_446137.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..47 8/42 (19%)
Involved in subunit assembly. /evidence=ECO:0000250 45..90 13/80 (16%)
Ion_trans_N 48..90 CDD:400630 12/77 (16%)
Ion_trans 92..357 CDD:459842 66/295 (22%)
Interaction with KCTD3. /evidence=ECO:0000250|UniProtKB:O88705 353..780 116/513 (23%)
CAP_ED 427..535 CDD:237999 38/111 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 549..569 6/42 (14%)
PHA03307 589..>772 CDD:223039 43/233 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 687..780 27/103 (26%)
Blue background indicates that the domain is not in the aligned region.

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