DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and Hcn3

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_446137.1	Gene:	Hcn3 / 114245	RGDID:	620691	Length:	780	Species:	Rattus norvegicus

Alignment Length:	928	Identity:	212/928 - (22%)
Similarity:	387/928 - (41%)	Gaps:	210/928 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 VRDDDNNSAAHSSDSKSPSQRKSRIG---DGASDPDSDWTRSNQRWMKLRTTVQISSAIQKKPPL 183
            |.|.:..:.|..:...:|:|.::..|   :.|.:|     :..|....|:.||...|
  Rat     9 VGDGEAATPARETPPAAPAQARAASGGVPESAPEP-----KRRQLGTLLQPTVNKFS-------- 60

  Fly   184 KREDSFLKRFSTRQIPE-TQETVEDTGSESASGDVDKSVKRRRRYLQKRRSVVNPDENFYFYWLM 247
                  |:.|.:.:..| .||.|:..|:                      .:::|..:|.|||.:
  Rat    61 ------LRVFGSHKAVEIEQERVKSAGA----------------------WIIHPYSDFRFYWDL 97

  Fly   248 MLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTG-YLEQGL-MVYDD 310
            ::.:.::.||..|.|..:|.:.:.|.|  |::.:.::|..|:||:::..||| .:|:|. ::...
  Rat    98 IMLLLMVGNLIVLPVGITFFKEENSPP--WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAP 160

  Fly   311 RKLACHYVHSRDFIFDMIALIPLDLLQLKMGTHP--------------LLRFTRFFKVYRSVRFY 361
            |.:...|:.:. |:.|:|:.||:|.:.|.:...|              ::|||:...:.|.:|..
  Rat   161 RAIRTRYLRTW-FLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLS 224

  Fly   362 YIVESRTVWPNLW-----------RVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYPYRPG 414
            .::.....|..::           |:.|||.::|:|.||.||..||:...:.|..| ||...|..
  Rat   225 RLIRYMHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVSMNRMV 289

  Fly   415 DYATLTRKYLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRN 478
            :: :..|:|..:|:.:...:..|| ....|....:...|::|.::|...:|..:|....:|.:.:
  Rat   290 NH-SWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLD 353

  Fly   479 ANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGG-GDINTALGLLPDKLKTEL 542
            ::|.:::......:.||..||:|...::|:..:|::     |.||. .|..:.||.|.:.|:.|:
  Rat   354 SSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEH-----RYQGKMFDEESILGELSEPLREEI 413

  Fly   543 ALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSET 607
            .......::..:.:|....|.|:..::.|::..:|.|||.:.|:|.|.|:|:.|..|:|.||:.
  Rat   414 INFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLAR- 477

  Fly   608 GKVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLG 672
            |...|.:..|.:||||.:|.   ..:|||.||:..|..|:|||.:...|.::::|..:...:|:.
  Rat   478 GARDTRLTDGSYFGEICLLT---RGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVA 539

  Fly   673 RKRLMEVRCVNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDK--LKHD 735
            ..||   |.:.||.:..|..:                       |:.|..|:|..::::  ::||
  Rat   540 MDRL---RRIGKKNSILQRKR-----------------------SEPSPGSSSGGVMEQHLVQHD 578

  Fly   736 ---VKGFRNVLKKSRTSRKSDESLEMQPLHNTSPRGSKILLKRMSRVRSDEKDADSAEAKDELHD 797
               .:|.|. |.....:|.|.:.:..:||.:...:.:.:               .|..|....|.
  Rat   579 RDMARGIRG-LAPGTGARLSGKPVLWEPLVHAPLQAAAV---------------TSNVAIALTHQ 627

  Fly   798 KTPSPIGAGLP--LLQRLRLLKEKQDREERAVKSTPPQKSPPHSHVTCTLSPQESIQEEPEREFS 860
            :.|.|:....|  ||.|            .|.:|.....||        |.|..:
  Rat   628 RGPLPLSPDSPATLLAR------------SARRSAGSPASP--------LVPVRA---------- 662

  Fly   861 EGFPLIQRLQQLKIKNEPQANAAEPGVVMVNTPPNISSKIDSHFAASQAGASH-----PGPNGGA 920
              .||:.|        .|.|:.:.     :..||..:    .|.:.|:.|.|.     |.|.||.
  Rat   663 --GPLLAR--------GPWASTSR-----LPAPPART----LHASLSRTGRSQVSLLGPPPGGGG 708

  Fly   921 IGISAPGQSLTVAQIKPIMKVSFKQKIQQMQGGGG----GASSSPGPSTGAIAKKEPP----KSL 977
            ..:...|:.|:.:|  |.:.       |:..|.|.    |:.|...|.:|.:||  ||    .|.
  Rat   709 RRLGPRGRPLSASQ--PSLP-------QRATGDGSPRRKGSGSERLPPSGLLAK--PPGTVQPSR 762

  Fly   978 ALVAKHATSEDPVAAAGL 995
            :.|.:..|...|..:|.:
  Rat   763 SSVPEPVTPRGPQISANM 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	60/249 (24%)
		Ion_trans_2	382..476	CDD:285168	25/95 (26%)
		Crp	550..>680	CDD:223736	41/129 (32%)
		CAP_ED	556..668	CDD:237999	38/111 (34%)
Hcn3	NP_446137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		8/42 (19%)
		Involved in subunit assembly. /evidence=ECO:0000250	45..90		13/80 (16%)
		Ion_trans_N	48..90	CDD:285597	12/77 (16%)
		Ion_trans	110..357	CDD:278921	60/250 (24%)
		Interaction with KCTD3. /evidence=ECO:0000250\|UniProtKB:O88705	353..780		125/537 (23%)
		Crp	421..>557	CDD:223736	45/142 (32%)
		CAP_ED	427..535	CDD:237999	38/111 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..569		6/42 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	687..780		27/103 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338705
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3503
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.890