DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cngl and Hcn2

DIOPT Version :9

Sequence 1:NP_001245691.1 Gene:Cngl / 32468 FlyBaseID:FBgn0263257 Length:1970 Species:Drosophila melanogaster
Sequence 2:NP_446136.1 Gene:Hcn2 / 114244 RGDID:620689 Length:863 Species:Rattus norvegicus


Alignment Length:993 Identity:209/993 - (21%)
Similarity:383/993 - (38%) Gaps:276/993 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 CNSDTDVISPTGTSISGGGGGGGAGGAGGSGGAGGHSDGGYHKRHHHKMVRDDDNNSAAHSSDSK 137
            |:.|        :|.:.|...|||.|..|.|......:|                       .::
  Rat    63 CSRD--------SSCTPGAAKGGANGECGRGEPQCSPEG-----------------------PAR 96

  Fly   138 SPSQRKSRIGDGASDPDSDWTRSNQRWMKLRTTVQISSAIQKKP---PLKREDSFLKR------- 192
            .|....|..| .||.|               ...:.:.:.:..|   |...:.|||:|       
  Rat    97 GPKVSFSCRG-AASGP---------------AAAEEAGSEEAGPAGEPRGSQASFLQRQFGALLQ 145

  Fly   193 -----FSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKRRS-VVNPDENFYFYWLMMLTV 251
                 ||.|..          ||:       |:|:|.:..::...: :::|..:|.|||...:.:
  Rat   146 PGVNKFSLRMF----------GSQ-------KAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLL 193

  Fly   252 CVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYL--EQGLMVYDDRKLA 314
            .::.||..:.|..:|.:.:.:.|  |::.:.::|..|::|:::..|||.:  :...::.|..|:.
  Rat   194 FMVGNLIIIPVGITFFKDETTAP--WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIK 256

  Fly   315 CHYVHSRDFIFDMIALIPLD--LLQLKMGTHP----------LLRFTRFFKVYRSVRFYYIVESR 367
            ..|:.:. |:.|.::.||:|  .|.::.|...          ::|||:...:.|.:|...::...
  Rat   257 KKYLRTW-FVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYI 320

  Fly   368 TVWPNLW-----------RVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYPYRPGDYATLT 420
            ..|..::           |:.|||.::|:|.||.||..||:...:.|..| ||......:: :.:
  Rat   321 HQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPSDCWVSINNMVNH-SWS 384

  Fly   421 RKYLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEF 484
            ..|..:|:.:...:..|| ....||:..:...|::|.::|...:|..:|....:|.:.:::|.::
  Rat   385 ELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQY 449

  Fly   485 ERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGG-GDINTALGLLPDKLKTELALHVNL 548
            :......:.||..||:|...::::..:|::     |.||. .|.::.||.|...|:.|:   ||.
  Rat   450 QEKYKQVEQYMSFHKLPADFRQKIHDYYEH-----RYQGKMFDEDSILGELNGPLREEI---VNF 506

  Fly   549 SVLKKVT---IFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKV 610
            :..|.|.   :|....|.|:..::.|:|..:|.|||.|.|:|.:.::|:.|..|::.||::..|.
  Rat   507 NCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE 571

  Fly   611 LTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKR 675
            : .:..|.:||||.:|.   ..:|||.||:..|..|:|||.::....:::||..:...:|:...|
  Rat   572 M-KLSDGSYFGEICLLT---RGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDR 632

  Fly   676 LMEVRCVNKKYA----KAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDV 736
            |..   :.||.:    |.|.|..:..:                   ::.||:..::||   |:| 
  Rat   633 LDR---IGKKNSILLHKVQHDLSSGVF-------------------NNQENAIIQEIV---KYD- 671

  Fly   737 KGFRNVLKKSRTSRK--------------SDESLEMQPLHNTSPRGSKILLKRMSRVRSDEKDAD 787
               |.:::::...::              :..:|:.....:..|:.::.|:              
  Rat   672 ---REMVQQAELGQRVGLFPPPPPPQVTSAIATLQQAVAMSFCPQVARPLV-------------- 719

  Fly   788 SAEAKDELHDKTPSPIGAGLPLLQRLRLLKEKQDREERAVKSTPPQKSPPHSHVTCTLSPQESIQ 852
                         .|:..|.|                |.|:..||...||      ..||.....
  Rat   720 -------------GPLALGSP----------------RLVRRAPPGPLPP------AASPGPPAA 749

  Fly   853 EEPEREFSEGFPLIQRLQQLKIKNEPQANAAEPGVVMVNTPPNISSKIDSHFAASQAGASHPGPN 917
            ..|....|   |...|.....:...| |....|.:     |....|:.....:|||....|..| 
  Rat   750 SPPAAPSS---PRAPRTSPYGVPGSP-ATRVGPAL-----PARRLSRASRPLSASQPSLPHGAP- 804

  Fly   918 GGAIGISAPGQSLTVAQIKPIMKVSFKQKIQQMQGGGGGASSS-----PGPSTGAIAKKEPPKSL 977
                   ||..:   |..:|                   ||||     |.|:|...|.....:. 
  Rat   805 -------APSPA---ASARP-------------------ASSSTPRLGPAPTTRTAAPSPDRRD- 839

  Fly   978 ALVAKHATSEDPVAAAGL 995
                    |..|.||:||
  Rat   840 --------SASPGAASGL 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CnglNP_001245691.1 Ion_trans 260..481 CDD:278921 54/247 (22%)
Ion_trans_2 382..476 CDD:285168 24/95 (25%)
Crp 550..>680 CDD:223736 41/132 (31%)
CAP_ED 556..668 CDD:237999 36/111 (32%)
Hcn2NP_446136.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..131 19/114 (17%)
Involved in subunit assembly. /evidence=ECO:0000250 131..182 13/67 (19%)
Ion_trans_N 140..182 CDD:285597 9/58 (16%)
Ion_trans 202..447 CDD:278921 54/248 (22%)
Crp 511..>646 CDD:223736 42/141 (30%)
CAP_ED 517..625 CDD:237999 36/111 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 730..863 39/174 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 217 1.000 Inparanoid score I3503
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.960

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