DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cngl and Kcnh4

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_446082.2	Gene:	Kcnh4 / 114032	RGDID:	621415	Length:	1016	Species:	Rattus norvegicus

Alignment Length:	586	Identity:	146/586 - (24%)
Similarity:	249/586 - (42%)	Gaps:	120/586 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 LICDSMTDVVFILDIIVQLRTGYLEQ-GLMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMG 341
            |:.|...:::||||||:..||.|:.| |.:|...|.:..||:.:..|: |:||.:|.|||.:...
  Rat   264 LVSDIAVEMLFILDIILNFRTTYVSQSGQVVSAPRSIGLHYLATWFFV-DLIAALPFDLLYVFNI 327

  Fly   342 THPLLRFTRFFKVYRSVRFYYIVESRTVWPNLWRVV--NLIHILLILAHWFGCFYFLLSEAEGFQ 404
            |  :.......|..|.:|...:::....:.....||  .|:.:..:||||..|.::::...|...
  Rat   328 T--VTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACVWYVIGRREMEA 390

  Fly   405 GD-------WVY--------PYRPGDYATLTRK--YLGSLYWSTLTLTTIG-DLPTPETNAEYIF 451
            .|       |::        ||..|.....:|:  |:.:||::..:||::| ......|:||.||
  Rat   391 NDPLLWDIGWLHELGKRLEEPYVNGSAGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIF 455

  Fly   452 TIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSW 516
            :|.:.|||..:.|.:.|.|..:|....:.|..:...:...|.::|.|::|..:|:|:|.::..:|
  Rat   456 SICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTW 520

  Fly   517 SRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGD 581
            :   :..|.|.|..|...||:|:.::|:|:|..:| ::.:|.......|..|.|.:|.....||:
  Rat   521 A---VNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGE 581

  Fly   582 SICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFG----EIG---------ILNLDGLNK 633
            .:.|:|:..:..:.:..|.||||.: ..||..:..||..|    |:|         :|      |
  Rat   582 FLLRRGDALQAHYYVCSGSLEVLRD-NTVLAILGKGDLIGADIPELGQEPGAGAGCVL------K 639

  Fly   634 RTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCVNKKYAKAQSDKEAAAY 698
            .:|||:::.|..|..||...:...::.||:                              ..||:
  Rat   640 TSADVKALTYCGLQQLSSRGLAEVLRLYPE------------------------------YVAAF 674

  Fly   699 AAAHPHHHQSH-HQGQVHQSDSSENSASKKI-----VDKLKHDVKGFRNVLKKSRTSRKSDESLE 757
            .|..|.....: .||       |||:...:.     :.:.:.|..|           ..||::|.
  Rat   675 RAGLPRDLTFNLRQG-------SENNGLGRFSRSPRLSQARSDTLG-----------SSSDKTLP 721

  Fly   758 --------MQPLHNTSPRGSKILLKRMSRVR---------SDEKDADSAEAKDELHDKTPSPIGA 805
                    |:|...:.|| ..:||..:|..|         .:|....||.........||||..|
  Rat   722 SITETEGGMEPGAGSKPR-RPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPTPSPALA 785

  Fly   806 G 806
            |
  Rat   786 G 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	63/223 (28%)
		Ion_trans_2	382..476	CDD:285168	31/111 (28%)
		Crp	550..>680	CDD:223736	33/142 (23%)
		CAP_ED	556..668	CDD:237999	32/124 (26%)
Kcnh4	NP_446082.2	PRK13559	41..>134	CDD:237427
		PLN03192	177..>620	CDD:215625	101/363 (28%)
		Selectivity filter. /evidence=ECO:0000250	439..444		1/4 (25%)
		CAP_ED	578..667	CDD:412130	25/95 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	689..748		15/77 (19%)
		PHA03247	<732..1007	CDD:223021	16/56 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..869		6/17 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..1016
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338751
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840