Protein Alignment Cngl and hcn4

DIOPT Version :9

• Sequence 1: NP_001245691.1
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: XP_002944030.2
• Gene: hcn4 / 100498501
• XenbaseID: XB-GENE-940130
• Length: 2061
• Species: Xenopus tropicalis
• Alignment Length: 1008
• Identity: 216/1008 - (21%)
• Similarity: 408/1008 - (40%)
• Gaps: 227/1008 - (22%)

  Fly   130 AAHSS---DSKSPSQRKSRI---GDGA-----SDPDSDWTRSNQRWMKLRTTVQISSAIQKKPPL 183
            ::||.   .|:||:|..|.:   .:|:     .||.....|            |..:.:|   |.
 Frog  1155 SSHSPAQISSQSPAQELSSLIPKLEGSEQTEVGDPGGFIQR------------QFGALLQ---PA 1204

  Fly   184 KREDSFLKRFSTRQIPE-TQETVEDTGSESASGDVDKSVKRRRRYLQKRRSVVNPDENFYFYWLM 247
            ..:.| |:.|.:.:..| .|:.|:..||                      .:::|..:|.|||.:
 Frog  1205 VNKFS-LRMFGSHKAVEIEQQRVKSAGS----------------------WIIHPYSDFRFYWDL 1246

  Fly   248 MLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYL--EQGLMVYDD 310
            ::.:.::.||..|.|..:|.:.:.:.|  |::.:.::|..|:.|:::..|||.:  :...::.|.
 Frog  1247 IMLLLMVANLIILPVGITFFKDENTPP--WIVFNVLSDTFFLADLVLNFRTGIVVEDNTEIILDP 1309

  Fly   311 RKLACHYVHSRDFIFDMIALIPLDL------LQLKMGTH--------PLLRFTRFFKVYRSVRFY 361
            ..:...|:.|. |:.|.::.||:|.      |:..:.|.        .::|||:...:.|.:|..
 Frog  1310 HTIKMKYLKSW-FLVDFVSSIPVDYIFLIVDLETNVDTEVYKTARALRIVRFTKILSLLRLLRLS 1373

  Fly   362 YIVESRTVWPNLW-----------RVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYPYRPG 414
            .::.....|..::           |:.|||.::|:|.||.||..||:...:.|..| ||......
 Frog  1374 RLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPEDCWVSINHMA 1438

  Fly   415 DYATLTRKYLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRN 478
            : .:..::|..:::.:...:..|| ....||...:...|::|.::|...:|..:|....:|.:.:
 Frog  1439 N-ESWGKQYSHAIFKAMSHMLCIGYGQQAPEGMTDVWLTMLSMIVGATCYAMFIGHATALIQSLD 1502

  Fly   479 ANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGG-GDINTALGLLPDKLKTEL 542
            ::|.:::......:.||..||:|...::|:..:|::     |.||. .|....||.|.:.||.|:
 Frog  1503 SSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHEYYEH-----RYQGKMFDEENILGELSEPLKEEI 1562

  Fly   543 ALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSET 607
            ......:::..:.:|....|.|:..::.|::..:|.|||.|.|:|.|.::|:.|..|::.:|:.
 Frog  1563 VNFNCRNLVANMPLFANADPNFVTAMLTKLRFEVFQPGDYIIREGTVGKKMYFIQHGVVSILTR- 1626

  Fly   608 GKVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLG 672
            |...|.:..|.:||||.:|.   ..:|||.||:..|..|:|||.::....:::||..:...:|:.
 Frog  1627 GSKETKLSDGSYFGEICLLT---RGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVA 1688

  Fly   673 RKRLMEVRCVNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSEN--------------- 722
            ..||..:...|....:.:::..:.:.      :::...|...|..|::.|
 Frog  1689 MDRLDRIGKKNSILLRKRAENSSGSV------NNEIIQQIVKHDRDTAHNIQDIQCLAATRDPNK 1747

  Fly   723 ---------------SASKKIVDKLKHDVKGFRNVLKK----------SRTSRKSDESLE-MQPL 761
                           :|:..:...|.|......||...          ||.:|:|..||. ..|.
 Frog  1748 PFIWEPLVHAPLQTAAATTNVAIALTHQQNLQANVFLPPLSLPETAYVSRQARRSQPSLRGSHPS 1812

  Fly   762 HNTSPRGSKILLKRMSRVRSDEKDADSAEAKDELHDKTPSPIGAGLPLLQRLRLLKEKQDREERA 826
            ..:||.|::..|:....:   ...:.|...|..::.:.|.     :|    :||.:.::...:.|
 Frog  1813 SVSSPSGTQSHLQTPLGI---SPSSPSGVQKQSINGQCPQ-----IP----IRLSQSQRGEPQTA 1865

  Fly   827 VKSTPPQKSPPHSHVTCTLSPQESIQEEPEREFSEGFPLIQRLQQLKIKNEPQANAAEPGVVMVN 891
            .|       ||       :.|.: :|....|..|....::|         :....|..|.|
 Frog  1866 AK-------PP-------ILPSQ-VQLSRSRGTSASTSVLQ---------QGMGPAGSPVV---- 1902

  Fly   892 TPPNISSKIDSHFAASQAGASHPGPNGGAIGI------SAPGQSLTVAQIK--PIMKV------- 941
             |.::|.: ..|::.|:|..||       |.:      |:|.|.:....|:  ||.::
 Frog  1903 -PGSLSGR-TLHYSLSRASGSH-------ISLLMQQAASSPQQLVKYRSIQGLPIGRLSQDVRLM 1958

  Fly   942 -----SFKQKIQQMQGGG----GGASSSPG----------PSTGAIAKKEPPKSLAL----VAKH 983
                 |...|:...|.|.    ....|||.          ||..|..:::|...|..    |:..
 Frog  1959 SASQPSLPNKVTHQQDGSMLQIASNKSSPTVSAMLVRPSLPSPSAHPQQQPSGPLVFSGRPVSGS 2023

  Fly   984 ATSEDPVAAAGLGLGSGSSSGIATISKRVVKPQ 1016
            ||.:.||:|......|...|.:.:....|.||:
 Frog  2024 ATPQSPVSAPRPAGQSRKGSVVFSSDVEVNKPK 2056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	54/249 (22%)
		Ion_trans_2	382..476	CDD:285168	23/95 (24%)
		Crp	550..>680	CDD:223736	39/129 (30%)
		CAP_ED	556..668	CDD:237999	36/111 (32%)
hcn4	XP_002944030.2	Plasmodium_HRP	<67..248	CDD:253181
		Ion_trans_N	1197..1239	CDD:285597	11/67 (16%)
		Ion_trans	1259..1506	CDD:278921	54/250 (22%)
		Crp	1570..>1708	CDD:223736	40/141 (28%)
		CAP_ED	1576..1684	CDD:237999	36/111 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910