DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and cnga4

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	XP_017945387.2	Gene:	cnga4 / 100489546	XenbaseID:	XB-GENE-996762	Length:	573	Species:	Xenopus tropicalis

Alignment Length:	536	Identity:	194/536 - (36%)
Similarity:	319/536 - (59%)	Gaps:	33/536 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 LRTTVQISSAIQKKPPLKREDSFLKRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKR 231
            :.|..|:.|  .:...:|.|    .:....:|....:.:|:|.:.|.               :.|
Frog     1 MNTLTQMMS--HRMERIKEE----AKMEKEEIKAWTQPMENTVNPST---------------RNR 44

  Fly   232 RSVVNPDENFYFYWLMMLTVCVLYNLWTLIV-RQSFPELQQSVPTFWLICDSMTDVVFILDIIVQ 295
            .|:::|..|:|:.||.::.:.|.|| |.:|: |..|||||......||..|.:.||::::|||..
Frog    45 SSILDPAGNWYYCWLNIMVLPVTYN-WVIIICRSCFPELQYQYLPVWLSLDYLCDVLYVMDIIAN 108

  Fly   296 LRTGYLEQGLMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGTH-PLLRFTRFFKVYRSVR 359
            ..||:||:|::|.|...:|.||:.|..|.:|:|:::|.|.|..|:|.| |.:|..||.:.:|...
Frog   109 FHTGFLEEGILVTDRHLIARHYISSSKFRWDLISVLPTDFLYFKLGIHTPAVRINRFLRFHRLFE 173

  Fly   360 FYYIVESRTVWPNLWRVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYP-YRPGDYATLTRK 422
            .:...|:|..:||.:|:..|:..:.::.||..|.||.||...||..| ||:| ....|:|.|.|:
Frog   174 SFDRTETRIPYPNAFRICKLMAYIFVVIHWNSCVYFALSSFIGFGKDKWVHPNITDSDFARLGRQ 238

  Fly   423 YLGSLYWSTLTLTTIGDLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERL 487
            ||.|.|:|||.|||:||:|.|....|::|.:|.:||.|..||||:|.:.:|::|.|:....|...
Frog   239 YLYSFYFSTLILTTVGDIPPPVQEEEWLFMVVDFLIAVLGFATIMGSMTSVVSNMNSADEAFYPN 303

  Fly   488 LDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLK 552
            .|..|.|::.:||...:|::|:.|:.:.....::....||   |..||:||:.|:|:.|:|.:|.
Frog   304 YDNVKLYLKMYKVNRSVKKKVIAWHQHLQIYKKLTNENDI---LQNLPEKLRVEVAVSVHLPILS 365

  Fly   553 KVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKV-LTTMKA 616
            ||.|||.|:...|.:||||:|..:::||:.:|:||::.|||:||.:|.|.|:::.|.. ...:..
Frog   366 KVQIFQNCEKSLLEELVLKLKPQVYSPGEYVCKKGDIGREMYIIKEGKLAVVADDGVTQFAELGE 430

  Fly   617 GDFFGEIGILNLDGL---NKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLME 678
            |::||||.|||:.|.   |:|||:::|:|||:||.||:||:..|:::||||:.||:..||:.|::
Frog   431 GNYFGEISILNIRGNTSGNRRTANIKSIGYSDLFCLSKEDLRDALREYPDAKAILEQKGREILLK 495

  Fly   679 VRCVNKKYAKAQSDKE 694
            :..::::.|...:.||
Frog   496 MNKLDEQLADELAAKE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	91/224 (41%)
		Ion_trans_2	382..476	CDD:285168	43/95 (45%)
		Crp	550..>680	CDD:223736	60/133 (45%)
		CAP_ED	556..668	CDD:237999	52/115 (45%)
cnga4	XP_017945387.2	Ion_trans	55..295	CDD:395416	97/240 (40%)
		CAP_ED	369..485	CDD:237999	52/115 (45%)
		CLZ	485..555	CDD:406832	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920