DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and kcnh7

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	XP_031749023.1	Gene:	kcnh7 / 100486080	XenbaseID:	XB-GENE-853944	Length:	1205	Species:	Xenopus tropicalis

Alignment Length:	1071	Identity:	235/1071 - (21%)
Similarity:	410/1071 - (38%)	Gaps:	265/1071 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 GHSDGGYHKRHHHKMVRD----DDNNSAAHSSDSKSPSQRKSRIGD----------------GAS 151
            |..|....||...::..|    ..:.|.|.|.||....:|.|.:.|                .:.
Frog   233 GPLDHSSPKRQWDQLFPDRLHAGSHISHARSKDSVCSMRRASSVHDIEGFSIHPKSVFRDRHASE 297

  Fly   152 DPDSDWTRSNQRWMKLRTTVQISSAIQKKPPLKREDSFLKRFST-RQIPETQETVEDTGSESASG 215
            |...|:..|:. ||.......|.|::..    ...||.|.::|| .:||:......|..:|..:.
Frog   298 DNGRDFKVSHS-WMTGGPFNHIKSSLLG----STSDSNLNKYSTINKIPQLTLNFSDVKNEKKAS 357

  Fly   216 DVDKS--------VKRRRRYLQKRRSVV--------------NPDENFY-----------FYWLM 247
            ....|        ||.|...:.::.:.|              .|..|.:           :.||:
Frog   358 SPPSSEKTIIAPKVKERTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLI 422

  Fly   248 MLTVCVLYNLWTLIV-------------RQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTG 299
            :|.|     ::|.|.             .|...|...|.....:: |.|.|::||:||::..||.
Frog   423 LLLV-----IYTAIFTPYSAAFLLNDREEQKRRECGYSCNPLNVV-DLMVDIMFIIDILINFRTT 481

  Fly   300 YLEQG-LMVYDDRKLACHYVHSRDFIFDMIALIPLDLLQLKMGTHPLLRFTRFFKVYRSVRFYYI 363
            |:.|. .:|.|..|:|.||.... |:.||:|.||.|||....|:..........|..|.:|...:
Frog   482 YVNQNEEVVSDPAKIAIHYFKGW-FLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRV 545

  Fly   364 VESRTVWPNLWRVV--NLIHILLILAHWFGCFYFLLSEAE-----------GFQGDWV-YPYR-- 412
            ......:......|  .|:.|..::|||..|.::.:...|           ...||.: .||.
Frog   546 ARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLIHKISWLDALGDQIKKPYNYS 610

  Fly   413 -PGDYATLTRKYLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVIT 475
             |....::..||:.:||::..:||::| ...:|.||:|.:|:|...|||..::|:|.|.|..:|.
Frog   611 DPSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQ 675

  Fly   476 NRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKT 540
            ...:....:...:...|.::|.|::|..:::|:..::.::||   ...|.|:|..|...|:.|:.
Frog   676 RLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWS---YTNGIDMNMVLKGFPECLQA 737

  Fly   541 ELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLS 605
            ::.||:|.::|:....|.......|..|.:|.|.....|||::...|::...::.::.|.:|:|.
Frog   738 DICLHLNKTLLQNCKAFSGASKGCLRALAMKFKTTHAPPGDTLVHSGDILTALYFLSRGSIEILK 802

  Fly   606 ETGKVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPD-AQEILQ 669
            : ..|:..:...|.|||:..|.... .|..||||::.|.:|..:.|||:|..:..||: :.:.|.
Frog   803 D-DIVVAILGKNDIFGEMVHLYAKP-GKSIADVRALTYCDLHKIQREDLLEVLDMYPEFSDQFLT 865

  Fly   670 TLGRKRLMEVRCVNKKYA------------------------KAQSDKEAAAYAAAHPHHHQSHH 710
            .|  :....:|..|.|.|                        |.:||::.:        ..:|.:
Frog   866 NL--ELTFNLRDENSKAALLRSHADIDFNGENCKLRRRKLSFKNKSDEDCS--------RDESQN 920

  Fly   711 QGQVHQSDSSENSASKKIVDKLKHDVKGFRNVLKKSRTSRKSDESLEMQPLHN---------TSP 766
            ..:....|:...|::||.:|            :|||.:|..|..  |.:||:.         :.|
Frog   921 GSESSTDDTRNYSSTKKNMD------------IKKSGSSSSSIN--ETKPLYTEISAYTSVFSKP 971

  Fly   767 RG----------SKILLKRMSRVRSDEKDADSAEAKDE-LHDKTPSPIGA-----GL-------- 807
            .|          :|:.|.:.|....|.....|.|.::. |||..|:....     |:
Frog   972 SGQQFEEAVCPSAKLNLGKRSASNKDITGTRSWERENAVLHDSAPNHSALNHTTWGICEADNDLT 1036

  Fly   808 --PLLQRLRLLKEKQDREE-------RAVKSTPPQKS----PPHSHVTCTLSPQESIQEEPEREF 859
              .:.:||.|::|:.:|.|       :|:.....::|    |.:|.||.:.            |:
Frog  1037 YGEMEKRLDLIQEQMNRLELQMTSDIQAILQLLQRQSSLIPPAYSMVTASC------------EY 1089

  Fly   860 SEGFPLIQRLQQLKIKNEPQANAAEPGVVMVNTPPNISSKIDSHFAASQAGASHPGPNGGAIGIS 924
            :.  |..:|:|.:..|                    .|.|.|..|:.|
Frog  1090 AR--PTARRVQSMHAK--------------------ASIKTDRSFSPS----------------- 1115

  Fly   925 APGQSLTVAQIKPIMKVSFKQKIQQMQGGGGGASSSP----GPSTGAIAKKEPPKSLALVAKHAT 985
              .||..:|:::       |.:.:..:....||..:|    .|:.|....:|.|  |....:|..
Frog  1116 --SQSPELAELE-------KSRPKSKESLSSGAHLNPTPEDNPAQGVDHGQEHP--LESQPRHCP 1169

  Fly   986 SE-DPVAAAGLGLGSGSSSGIATISKRVVKP 1015
            |. :|:....|...|.:|.|:..:::....|
Frog  1170 SYLNPIRHTSLPDSSVNSLGVVGLNRHESDP 1200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	68/252 (27%)
		Ion_trans_2	382..476	CDD:285168	32/109 (29%)
		Crp	550..>680	CDD:223736	34/130 (26%)
		CAP_ED	556..668	CDD:237999	31/112 (28%)
kcnh7	XP_031749023.1	PAS_9	29..134	CDD:404329
		Ion_trans	417..679	CDD:395416	73/268 (27%)
		CAP_ED	753..864	CDD:237999	31/112 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910