Protein Alignment Cngl and hcn1

DIOPT Version :10

• Sequence 1: NP_727848.3
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: XP_068072094.1
• Gene: hcn1 / 100334297
• ZFINID: ZDB-GENE-110520-1
• Length: 925
• Species: Danio rerio
• Alignment Length: 1004
• Identity: 215/1004 - (21%)
• Similarity: 400/1004 - (39%)
• Gaps: 268/1004 - (26%)

  Fly   185 REDSFLKR-FSTRQIPETQE-TVEDTGSESASGDVDKSVKRRRRYLQKRRS-VVNPDENFYFYWL 246
            |:..|::| |.....|...: ::...||:       |:|::.:..:|.... :::|..:|.|||.
Zfish    66 RQYGFMQRQFGAMMQPGVNKFSLRMFGSQ-------KAVEKEQERVQTAGYWIIHPYSDFRFYWD 123

  Fly   247 MMLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYL--EQGLMVYD 309
            :::.:.::.||  :|:........:...|.||:.:..:|.:|::|:::..|||.:  |...::.|
Zfish   124 LIMLIMMMGNL--IIIPVGITFFSEQTTTSWLVFNVASDTIFLVDLVMNFRTGIVNEESSEIILD 186

  Fly   310 DRKLACHYVHSRDFIFDMIALIPLD--LLQLKMGTHP----------LLRFTRFFKVYRSVRFYY 362
            .:.:..:|:.|. |:.|.::.||:|  .|.::.|...          ::|||:...:.|.:|...
Zfish   187 PKVIKMNYLKSW-FVVDFLSSIPVDYIFLIVEKGFDSEVYKTARALRIVRFTKILSLLRLLRLSR 250

  Fly   363 IVESRTVWPNLW-----------RVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYPYRPGD 415
            ::.....|..::           |:.|||.::|:|.||.||..||:...:.|..| ||
Zfish   251 LIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWV------- 308

  Fly   416 YATLT--------RKYLGSLYWSTLTLTTIGDLPTPETNAEPNFSVDGPRSIPRRGIKSRLLQFG 472
              :|.        ::|..:|:.:...:..||            :....|.|:....|
Zfish   309 --SLNGMVNDSWGKQYSYALFKAMSHMLCIG------------YGARAPVSMSDLWI-------- 351

  Fly   473 SSYGYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVL 537
                   |::|.::|...:|..||....:|.:.:::|.:::......:.||..||:|..|::::.
Zfish   352 -------TMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIH 409

  Fly   538 RWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVT---IFQECQPEFLHDLVLK 599
            .:|::.: :|:|   .|.::.|..|.|.||.|:   ||.:..|.|.   :|....|.|:..::.|
Zfish   410 DYYEHRY-QGKI---FDEDSILNELNDPLKEEI---VNFNCRKLVATMPLFANADPNFVTGMLSK 467

  Fly   600 MKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKAGDFFGEIGILNLDGLNKRTA 664
            :|..:|.|.|.|.|:|.|.::|:.|..|:..|:::..|.| .:..|.:||||.:|.   ..:|||
Zfish   468 LKFEVFQPNDYIIREGTVGKKMYFIQHGVASVITKFNKEL-KLTDGSYFGEICLLT---KGRRTA 528

  Fly   665 DVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCVNKKYAKAQSDKEAAAYAAA 729
            .||:..|..|||||.:.....:::||..:...:|:...||
Zfish   529 SVRADTYCRLFSLSVDHFNEVLEEYPMMRRAFETVAIDRL------------------------- 568

  Fly   730 HPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDVKGFRNVLKKSRTSRKSDESLEMQPLHNTSP 794
                                        |::.|.:|...|:....:|.||.
Zfish   569 ----------------------------DRIVHKIKPEDNLRCDPKTQRKK-------------- 591

  Fly   795 RGSKILLKRMSRVRSDEKDADSAEAKDELHDKTPSPIGAGLPLLQRLRLLKEKQESIQEEPEREF 859
              :.:||::.      :||                 :.||:...|...|||   :.|:::.|...
Zfish   592 --NSLLLQKF------QKD-----------------LNAGVFNTQENELLK---QIIRQDREMVM 628

  Fly   860 SEGFPLIQRLQQLKIKNEPQANAAEPGVVMVNTPPNISSKIDSHFAASQAGASHPGPNGGAIGIS 924
                 ::.|.|.:...|              :||.:.:|.|:|......|.|:....|......:
Zfish   629 -----MVDRKQSVTGMN--------------STPMSGNSIINSPAQPPFATATAILGNNQLQQQA 674

  Fly   925 APGQSLTVAQIKPIMKVSFKQKI---QQMQGGGGGASSSPGPSTGAIAKKEPPKSLALVAKHATS 986
            ||....|.|.|.|..:|...|.:   ......|..:||||.|.|   ..::|..::.......||
Zfish   675 APLSYSTSATITPSGRVPPSQGVTFSAPSVSHGNLSSSSPNPPT---PLQQPAGAIMSPCSFTTS 736

  Fly   987 ------EDPVAAAGLGLGSGSSSGIATISKRVVK------------PQSHRMATPLQSDTDTDGT 1033
                  :.|:|:.....||.::|.::.:.:.:.:            .|..:.|:|.:||......
Zfish   737 ICSPPVQTPIASRTFQYGSPTASQLSLVQQALPQQSSPASLPQPPAQQQPQGASPQRSDVHKSAQ 801

  Fly  1034 PIKPWSKLKLATLMSSSYTSLTN----------CSPDDLA-----------------SPLKNYSL 1071
            .::..|..|....:|:|..||.:          .|.:.||                 |.|::...
Zfish   802 ALQSGSLSKDLRHLSASQPSLPHETSLAARAHPTSGESLASIQPPPMGSAAGIQAPGSVLQSGIR 866

  Fly  1072 SNIPQ------QMESHTRPRHHSARSSSR 1094
            :|:||      ||.|...|...:|.||::
Zfish   867 TNVPQRVALFRQMSSGALPPVRTAPSSAQ 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_727848.3	Ion_trans	240..509	CDD:459842	64/302 (21%)
		CAP_ED	584..696	CDD:237999	37/111 (33%)
		dermokine	<1688..>1775	CDD:455732
hcn1	XP_068072094.1	Ion_trans_N	75..117	CDD:400630	8/48 (17%)
		PLN03192	110..>614	CDD:215625	140/645 (22%)
		CAP_ED	452..560	CDD:237999	37/111 (33%)
		PHA03247	<653..906	CDD:223021	52/246 (21%)