DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cngl and LOC100334297

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	XP_017208463.1	Gene:	LOC100334297 / 100334297	-ID:	-	Length:	908	Species:	Danio rerio

Alignment Length:	935	Identity:	216/935 - (23%)
Similarity:	395/935 - (42%)	Gaps:	221/935 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 REDSFLKR-FSTRQIPETQE-TVEDTGSESASGDVDKSVKRRRRYLQKRRS-VVNPDENFYFYWL 246
            |:..|::| |.....|...: ::...||:       |:|::.:..:|.... :::|..:|.|||.
Zfish    66 RQYGFMQRQFGAMMQPGVNKFSLRMFGSQ-------KAVEKEQERVQTAGYWIIHPYSDFRFYWD 123

  Fly   247 MMLTVCVLYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYL--EQGLMVYD 309
            :::.:.::.||  :|:........:...|.||:.:..:|.:|::|:::..|||.:  |...::.|
Zfish   124 LIMLIMMMGNL--IIIPVGITFFSEQTTTSWLVFNVASDTIFLVDLVMNFRTGIVNEESSEIILD 186

  Fly   310 DRKLACHYVHSRDFIFDMIALIPLD--LLQLKMGTHP----------LLRFTRFFKVYRSVRFYY 362
            .:.:..:|:.|. |:.|.::.||:|  .|.::.|...          ::|||:...:.|.:|...
Zfish   187 PKVIKMNYLKSW-FVVDFLSSIPVDYIFLIVEKGFDSEVYKTARALRIVRFTKILSLLRLLRLSR 250

  Fly   363 IVESRTVWPNLW-----------RVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYPYRPGD 415
            ::.....|..::           |:.|||.::|:|.||.||..||:...:.|..| ||
Zfish   251 LIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWV------- 308

  Fly   416 YATLT--------RKYLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVG 471
              :|.        ::|..:|:.:...:..|| ....|.:.::...|::|.::|...:|..||...
Zfish   309 --SLNGMVNDSWGKQYSYALFKAMSHMLCIGYGARAPVSMSDLWITMLSMIVGATCYAMFVGHAT 371

  Fly   472 NVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPD 536
            .:|.:.:::|.:::......:.||..||:|..|::::..:|::.: :|:|   .|.::.|..|.|
Zfish   372 ALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRY-QGKI---FDEDSILNELND 432

  Fly   537 KLKTELALHVNLSVLKKVT---IFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIAD 598
            .||.|:   ||.:..|.|.   :|....|.|:..::.|:|..:|.|.|.|.|:|.|.::|:.|..
Zfish   433 PLKEEI---VNFNCRKLVATMPLFANADPNFVTGMLSKLKFEVFQPNDYIIREGTVGKKMYFIQH 494

  Fly   599 GILEVLSETGKVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPD 663
            |:..|:::..|.| .:..|.:||||.:|.   ..:|||.||:..|..|||||.:.....:::||.
Zfish   495 GVASVITKFNKEL-KLTDGSYFGEICLLT---KGRRTASVRADTYCRLFSLSVDHFNEVLEEYPM 555

  Fly   664 AQEILQTLGRKRLMEVRCVNKKYA----KAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSA 724
            .:...:|:...||..   :.||.:    |.|.|..|..:                   ::.||..
Zfish   556 MRRAFETVAIDRLDR---IGKKNSLLLQKFQKDLNAGVF-------------------NTQENEL 598

  Fly   725 SKKI----------VDKLKHDVKGFRNVLKK--------------SRTSRKSDESLEMQ--PL-H 762
            .|:|          ||: |..|.|..:....              :.|:...:..|:.|  || :
Zfish   599 LKQIIRQDREMVMMVDR-KQSVTGMNSTPMSGNSIINSPAQPPFATATAILGNNQLQQQAAPLSY 662

  Fly   763 NTS----PRGSKILLKRMSRVRSDEKDADSAE--AKDELHDKTPS-------PIGA--------- 805
            :||    |.|         ||...:....||.  :...|...:|:       |.||
Zfish   663 STSATITPSG---------RVPPSQGVTFSAPSVSHGNLSSSSPNPPTPLQQPAGAIMSPCSFTT 718

  Fly   806 ------------------GLPLLQRLRLLKEKQDREERAVKSTPPQKSPPHSHVTCTLSPQESIQ 852
                              |.|...:|.|           |:...||:|.|.|      .||...|
Zfish   719 SICSPPVQTPIASRTFQYGSPTASQLSL-----------VQQALPQQSSPAS------LPQPPAQ 766

  Fly   853 EEPE---REFSEGFPLIQRLQQLKI-KNEPQANAAEPGVVMVNTPPNISSKIDSHFAASQAGAS- 912
            ::|:   .:.|:.....|.||...: |:....:|::|.:     |...|....:|..:.::.||
Zfish   767 QQPQGASPQRSDVHKSAQALQSGSLSKDLRHLSASQPSL-----PHETSLAARAHPTSGESLASI 826

  Fly   913 HPGPNGGAIGISAPGQSLTVAQIKPIMKVSFKQKI---QQMQGGG------GGASSSPGPSTGAI 968
            .|.|.|.|.||.|||..|...     ::.:..|::   :||..|.      ..:|:....|||
Zfish   827 QPPPMGSAAGIQAPGSVLQSG-----IRTNVPQRVALFRQMSSGALPPVRTAPSSAQHRDSTG-- 884

  Fly   969 AKKEPPKSLALVAKHATSEDPVAAA 993
            :::|.    |:::...|.:|.:..|
Zfish   885 SRRES----AVLSSTETEQDKMRFA 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	56/255 (22%)
		Ion_trans_2	382..476	CDD:285168	25/103 (24%)
		Crp	550..>680	CDD:223736	42/132 (32%)
		CAP_ED	556..668	CDD:237999	37/111 (33%)
LOC100334297	XP_017208463.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840