DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and HCN4

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_005468.1	Gene:	HCN4 / 10021	HGNCID:	16882	Length:	1203	Species:	Homo sapiens

Alignment Length:	1296	Identity:	283/1296 - (21%)
Similarity:	496/1296 - (38%)	Gaps:	356/1296 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AAAASSSSSGATATGLYTMEAHEHEAGKFVKDVARQVHDCNSDTDVISPTGTSISGGGGGGGAGG 98
            :|||..:.|.::|.|....|.....|||           .:::.|.....|:..|.|..|||:||
Human    59 SAAAGGTESRSSALGAADSEGPARGAGK-----------SSTNGDCRRFRGSLASLGSRGGGSGG 112

  Fly    99 AGGSGGAGGHSDGGYHKRHHHKMVRDDDNN------------------SAAHSSDSKSPSQR--- 142
            . |||.:.||......:|   :::.:.|.:                  ::|..:.|..|.|:
Human   113 T-GSGSSHGHLHDSAEER---RLIAEGDASPGEDRTPPGLAAEPERPGASAQPAASPPPPQQPPQ 173

  Fly   143 ---------------KSRIGDGASD---PDSDWTRSNQRWMKLRTTVQISSAIQKKPPLKREDSF 189
                           |...|..|.|   |:::.......:|:.:....:...:.|
Human   174 PASASCEQPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQFGAMLQPGVNK---------- 228

  Fly   190 LKRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKRRS-VVNPDENFYFYWLMMLTVCV 253
               ||.|..          ||:       |:|:|.:..::.... :::|..:|.|||.:.:.:.:
Human   229 ---FSLRMF----------GSQ-------KAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLM 273

  Fly   254 LYNLWTLIVRQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYL--EQGLMVYDDRKLACH 316
            :.||..:.|..:|.:.:.:.|  |::.:.::|..|::|:::..|||.:  :...::.|.:::...
Human   274 VGNLIIIPVGITFFKDENTTP--WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMK 336

  Fly   317 YVHSRDFIFDMIALIPLDLLQLKMGTH------------PLLRFTRFFKVYRSVRFYYIVESRTV 369
            |:.|. |:.|.|:.||:|.:.|.:.|.            .::|||:...:.|.:|...::.....
Human   337 YLKSW-FMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQ 400

  Fly   370 WPNLW-----------RVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-WVYPYRPGDYATLT-- 420
            |..::           |:||||.::|:|.||.||..||:...:.|..| ||         ::.
Human   401 WEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWV---------SINNM 456

  Fly   421 ------RKYLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRN 478
                  ::|..:|:.:...:..|| ....|...::...|::|.::|...:|..:|....:|.:.:
Human   457 VNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLD 521

  Fly   479 ANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGG-GDINTALGLLPDKLKTEL 542
            ::|.:::......:.||..||:|...::|:..:|::     |.||. .|..:.||.|.:.|:.|:
Human   522 SSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEH-----RYQGKMFDEESILGELSEPLREEI 581

  Fly   543 ALHVNLSVLKKVT---IFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVL 604
               :|.:..|.|.   :|....|.|:..::.|::..:|.|||.|.|:|.:.::|:.|..|::.||
Human   582 ---INFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVL 643

  Fly   605 SETGKVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQ 669
            :: |...|.:..|.:||||.:|.   ..:|||.||:..|..|:|||.::....:::||..:...:
Human   644 TK-GNKETKLADGSYFGEICLLT---RGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFE 704

  Fly   670 TLGRKRLMEVRCVNKKYA----KAQSDKEAAAYAAAHPHHHQSHHQGQVHQSDSSENSASKKIVD 730
            |:...||..   :.||.:    |.|.|..:..:                   :..||...::||
Human   705 TVALDRLDR---IGKKNSILLHKVQHDLNSGVF-------------------NYQENEIIQQIV- 746

  Fly   731 KLKHDVKGFRNVLKKSRTSRKSDESLEMQPLHNTSPRGSKILLKRMSRVRSDEKDADSAEAKDEL 795
              :||    |.:...:.         .:|...:.:|..:.::...:.     :....:|.|...:
Human   747 --QHD----REMAHCAH---------RVQAAASATPTPTPVIWTPLI-----QAPLQAAAATTSV 791

  Fly   796 ------HDKTPS-----PIGAGLPLL---QRLRLLKEKQDREERAVKSTPPQKSPPHSHVTCTLS 846
                  |.:.|:     |.|:||..|   |..|.||..|.....|:.|..|..||  |.|....|
Human   792 AIALTHHPRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPASSP--SQVDTPSS 854

  Fly   847 PQESIQEEPEREFSEGFPLIQRLQQLKIKNEPQANAA-EPGVVMVNTPPNISSKIDS-------H 903
            ....||:      ..||.....|..|.    |.:::: .||.....:.|..|:.:.:       |
Human   855 SSFHIQQ------LAGFSAPAGLSPLL----PSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGH 909

  Fly   904 F-----------------------AASQAGASHPGPNG--GAIGI---------------SAPGQ 928
            |                       .:.||....|.|.|  |.:|:               |:|||
Human   910 FHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSPGQ 974

  Fly   929 --------SLTVA------------QIKPIMKVSFKQKIQQMQGGGGGAS----------SSPGP 963
                    ||.:|            |.:|...|:         |..||||          |.||.
Human   975 LGQPPGELSLGLATGPLSTPETPPRQPEPPSLVA---------GASGGASPVGFTPRGGLSPPGH 1030

  Fly   964 STGAIAKKEPPKSLALVAKHATSEDPVAAAGLGLGSGSSSGIATISKRVVKPQSHRMATPLQSDT 1028
            |.|      ||::.       .|..|.|:     ||..|..:...|.........|..||
Human  1031 SPG------PPRTF-------PSAPPRAS-----GSHGSLLLPPASSPPPPQVPQRRGTP----- 1072

  Fly  1029 DTDGTPIKPWSKLKLATLMSSSYTSLTNCSPDDLASPLKNYSLSNIPQQMESHTR-PRHHSARSS 1092
                 |:.|....:...|:|:|..:|    |.|.|..|:..|..:..:.|.:... ||.......
Human  1073 -----PLTPGRLTQDLKLISASQPAL----PQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGG 1128

  Fly  1093 SRS------PRHGHHHHHHHGHH-------QHGQLQGPSSTCTNGSTTSQVNQVTASAKRD 1140
            |.|      |  |..:....|.|       ..|.|..|.|.....:|:|....:||..:|:
Human  1129 SGSSGGLGPP--GRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQRE 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	55/255 (22%)
		Ion_trans_2	382..476	CDD:285168	23/103 (22%)
		Crp	550..>680	CDD:223736	41/132 (31%)
		CAP_ED	556..668	CDD:237999	36/111 (32%)
HCN4	NP_005468.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..182		30/137 (22%)
		Involved in subunit assembly. /evidence=ECO:0000250	209..260		11/80 (14%)
		Ion_trans_N	218..260	CDD:285597	10/71 (14%)
		Ion_trans	280..525	CDD:278921	55/256 (21%)
		Crp	589..>724	CDD:223736	42/141 (30%)
		CAP_ED	595..703	CDD:237999	36/111 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	836..856		8/21 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	870..897		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1203		68/313 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840