Protein Alignment Cngl and kcnh4a

DIOPT Version :9

• Sequence 1: NP_001245691.1
• Gene: Cngl / 32468
• FlyBaseID: FBgn0263257
• Length: 1970
• Species: Drosophila melanogaster
• Sequence 2: NP_001309362.1
• Gene: kcnh4a / 100148126
• ZFINID: ZDB-GENE-131125-34
• Length: 1151
• Species: Danio rerio
• Alignment Length: 1121
• Identity: 246/1121 - (21%)
• Similarity: 419/1121 - (37%)
• Gaps: 275/1121 - (24%)

  Fly   126 DNNSAAHSSDSKSPSQRKSR-IGDGASDPDSDWTRSNQRWMKLRTTVQISSAIQKKPPLKREDSF 189
            |:...:|...|....:|..| :|    .......|...|.:....|.|.::..::|.|
Zfish   135 DSYGKSHLGSSTEEDRRHGRKVG----RTHLSQARERGRNVLYHLTCQFTNRSKRKLP------- 188

  Fly   190 LKRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKRRSVVNPDENFYFYWLMML----- 249
            ...||...:||.:           ...|.||     |::....||...    .:.||::|
Zfish   189 NNVFSQPTLPEYK-----------VASVQKS-----RFILLHYSVCKA----MWDWLILLATFYV 233

  Fly   250 TVCVLYNLWTLIVRQS---FPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYL-EQGLMVYDD 310
            .|.|.||:.......|   .|:...|..| .::.|...:::||||||:..||.|: ..|.:|||.
Zfish   234 AVTVPYNVCFSTPDDSQLDSPDCDSSSRT-TIVSDIAVEMLFILDIILNFRTTYVGPAGQVVYDT 297

  Fly   311 RKLACHYVHSRDFIFDMIALIPLDLLQL-KMGTHPLLRFTRFFKVYRSVRFYYIVESRTVWPNLW 374
            |.:..||. :..||.|:||.:|.|||.| .:....|:...:..::.|.:|....::..:.:..:.
Zfish   298 RSICLHYC-TTWFILDLIAALPFDLLYLFNISVTSLVHLLKTVRLLRLLRLLQKLDGYSQYSAVV 361

  Fly   375 RVVNLIHILLILAHWFGCFYFLLSEAEGFQGD-------WVY--------PYRPGDYA--TLTRK 422
            ..: |:.:..:||||..|.::::...|....|       |:.        ||..|...  :|...
Zfish   362 LTL-LMSVFALLAHWLACVWYVIGRQELASNDPLTWDIGWLQELGKRLETPYTNGTVGGPSLRSA 425

  Fly   423 YLGSLYWSTLTLTTIG-DLPTPETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFER 486
            |:.|||::..:||::| ......|:||.||:|.:.|||..:.|.:.|.|..:|....:.|..:..
Zfish   426 YIASLYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHT 490

  Fly   487 LLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVL 551
            .:...|.::|.|::|..:|:|:|.::..:||   :..|.:.|..|...||:|:.::|:|:|..:|
Zfish   491 RMKDLKDFIRVHRLPQQLKQRMLEYFQTTWS---VNNGINANELLHDFPDELRADIAMHLNKDIL 552

  Fly   552 KKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKVLTTMKA 616
             ::.:|.......|..|.|.:|.....||:.:.|.|:.......:..|.||||.: |.||..:..
Zfish   553 -QLPLFSSASRGCLRSLSLHIKTSFCAPGEYLIRHGDALHAQHFVCSGSLEVLKD-GMVLAILGK 615

  Fly   617 GDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPD-----AQEILQTL----- 671
            ||..| ..:...|.:.|..|||:::.|.:|..:|...:...::.||:     .::|...|
Zfish   616 GDLVG-ADLPGKDQVIKANADVKALTYCDLQYISVRALQEVLELYPEYGSRFNEDIHHNLTYNLR 679

  Fly   672 -GRKRL-MEVRCVNKKYAKAQSDKEAAAYAAAHPHHHQSHHQGQVHQS------------DSSEN 722
             |:.|. ...|...:|:.:.:.           |...::..:....|.            .||::
Zfish   680 EGQARFSRSTRLAQEKFDECKL-----------PFIVETEQEDDTGQDLGRRPLLSGFSCPSSQS 733

  Fly   723 SASKKIVDKLKHDVKGFRNVLKKSRTSRKSDESLEMQ-PLHNTS-------PRGSKILLKRMSRV 779
            :.|..:.::.:|     .|:|:..|:..:|......| |||...       |:..||...|.:::
Zfish   734 NLSAMLGEEFRH-----HNMLRFCRSPVQSSRIQSPQIPLHEEQTTASAPVPKTDKISCNRPAKL 793

  Fly   780 ------------------------------RSDEKDADSAEAKDELHDKTPSPIGAGLPL----- 809
                                          ..:..::.:.|.||      |..:||.|.|
Zfish   794 LIPTLNCVSPLDLSPRVVDGIEDNEHAFHFNVEHSESPNTEVKD------PFQVGANLLLETEEV 852

  Fly   810 LQRLRLLKEKQDREERAVKSTPPQKSPP----HSHVT------------------CTLSPQESIQ 852
            .|.||.|..:.:...:.|.|...:....    |:|||                  || |...|..
Zfish   853 RQSLRQLNTEMNHLNQEVTSLTKELHEMMQFLHAHVTQPHFPSSFTPFACHTSSNCT-SVATSTT 916

  Fly   853 EEPEREFSEGFPLIQRLQQLKIKNEPQANAAEPGVVMVNTPPNISSKIDSHFAASQA---GASHP 914
            :.|.| .|...|....||            |||            |:.|| |....:   ..|||
Zfish   917 DWPSR-LSYSMPSGPCLQ------------AEP------------SRRDS-FTPRHSCICSGSHP 955

  Fly   915 GPNGGAIGISAPGQSLTVAQI------------KPIMKVSFKQKIQQMQGGGGGASSSPG----- 962
            ...|..:|.....:.|..|||            :.:..:..:.:....|    .::::|.
Zfish   956 QERGSILGQEGDLELLNQAQIPHSTYFPCCPDQERVATLGVENQASPYQ----TSNTTPNSPYLG 1016

  Fly   963 --PSTGAIAKKEPPKSLALVAKHATSED---PVAAAGLGLGSGSSSGIATISKRVVKPQSHRMAT 1022
              |...|:....|...|....:.|.:..   |.:|..:...|..|..:..||      :.|..||
Zfish  1017 HRPPHAALTSSFPSSGLVPQVRSAVAPSNALPTSAHNIQSQSHGSLNVQMIS------EMHPRAT 1075

  Fly  1023 PLQSDTDTDGTPI--------KPWSKLKLATLMSSSYTSLTNCS-----------PDDLASPLKN 1068
            |         |||        .|...:.::::|.|..     ||           .:||......
Zfish  1076 P---------TPIHLSVTPTGPPQPLISVSSIMHSGI-----CSSSLLHFPAGQRQNDLVGSSPV 1126

  Fly  1069 YSLSNIPQQMESHTRP 1084
            ::|.||....|:::.|
Zfish  1127 HTLENIVVSTENNSAP 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	67/243 (28%)
		Ion_trans_2	382..476	CDD:285168	32/111 (29%)
		Crp	550..>680	CDD:223736	35/141 (25%)
		CAP_ED	556..668	CDD:237999	30/116 (26%)
kcnh4a	NP_001309362.1	PAS	42..133	CDD:238075
		PAS_3	42..127	CDD:285623
		Ion_trans	267..486	CDD:278921	63/220 (29%)
		Ion_trans_2	<426..480	CDD:285168	20/53 (38%)
		Crp	553..745	CDD:223736	41/204 (20%)
		CAP_ED	556..666	CDD:237999	30/111 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578348
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840