DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cngl and cnga1a

DIOPT Version :9

Sequence 1:	NP_001245691.1	Gene:	Cngl / 32468	FlyBaseID:	FBgn0263257	Length:	1970	Species:	Drosophila melanogaster
Sequence 2:	NP_001139095.1	Gene:	cnga1a / 100001558	ZFINID:	ZDB-GENE-090312-66	Length:	697	Species:	Danio rerio

Alignment Length:	743	Identity:	233/743 - (31%)
Similarity:	386/743 - (51%)	Gaps:	95/743 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 VRDDDNNSAAHSSDSKSPSQRKSRIGDGASDPDSDWTRSNQRWMKLRTTVQISSAIQKKPPLKRE 186
            |.:.:||........|...::|.:..........:..:.|::              ||....::|
Zfish    41 VNNSNNNEEEEKKKKKEKKEKKEKKEKKEKKEKKEKNQKNEK--------------QKDNEKEKE 91

  Fly   187 DSFLKRFSTRQIPETQETVEDTGSESASGDVDKSVKRRRRYLQKRRSVVNPDENFYFYWLMMLTV 251
            ....|        |.::..|....:....:.:|..::.::...|...|:||....|:.||:::|.
Zfish    92 KEKEK--------EKEKEKEKEKEKEKEKEKEKEKEKEKKEGPKEVFVINPAGLLYYQWLLIITF 148

  Fly   252 CVLYNLWTLIV-RQSFPELQQSVPTFWLICDSMTDVVFILDIIVQLRTGYLEQGLMVYDDRKLAC 315
            .|:|| ||:|: |..|.|||......|.:.|..:|::::.|:..:.|||||||||:|.|::.|..
Zfish   149 PVMYN-WTVIIARACFEELQHEYLLTWFLLDYTSDLLYLADMAFRARTGYLEQGLLVKDEKLLLK 212

  Fly   316 HYVHSRDFIFDMIALIPLDLLQLKMG-THPLLRFTRFFKVYRSVRFYYIVESRTVWPNLWRVVNL 379
            .|..|..|..|:|:::|.|:....:| .:|.:|..:..::.|...|:.|.|:.|.:||::|:..|
Zfish   213 RYTDSLQFRLDVISMLPTDIFYFILGLDYPEIRINKLLRLNRMFEFFKISETMTNYPNIFRICTL 277

  Fly   380 IHILLILAHWFGCFYFLLSEAEGFQGD-WVYP-YRPGDYATLTRKYLGSLYWSTLTLTTIGDLPT 442
            :..::|:.||..|.||..|::.||..| |||| ....::..|.|||..|||||||||||||:.|:
Zfish   278 VMYIIIIIHWNACLYFSFSKSIGFGSDAWVYPALTEPEFGELMRKYSFSLYWSTLTLTTIGETPS 342

  Fly   443 PETNAEYIFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRR 507
            ||.::|:.|.:|.:|:||.|||||||.:..:|:|.||.:.:|:..:|..|.||....|...::.|
Zfish   343 PELDSEFFFHVVDFLVGVLIFATIVGNIATMISNMNAAQAQFQARIDNIKQYMHARHVSKELEDR 407

  Fly   508 VLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKM 572
            |::|:||.|:..:.|   |....|..|||||:.|:.::|:|..||||.||.:|:...|.:||||:
Zfish   408 VIKWFDYLWTNKKAQ---DEREVLRYLPDKLRAEIGMNVHLDTLKKVRIFADCEAGLLIELVLKL 469

  Fly   573 KAYIFTPGDSICRKGEVAREMFIIADGILEVLSETGKV-LTTMKAGDFFGEIGILNLDGL---NK 633
            :..:|:|||.|||||::.|||:||.||.|.|:::.|.. ...:..|.:||||.|||:.|.   |:
Zfish   470 RPQVFSPGDYICRKGDIGREMYIIKDGKLAVVADDGVTQFVVLGDGSYFGEISILNIKGSKAGNR 534

  Fly   634 RTADVRSVGYSELFSLSREDVLAAMKDYPDAQEILQTLGRKRLMEVRCVNKKYAKAQSDKEAAAY 698
            |||::||:|||:||.||::|::.|:.:||||:.:|:..||:.|::...:....:|.:.|:.
Zfish   535 RTANIRSIGYSDLFCLSKDDLMEALTEYPDAKAMLEEKGRQILLKDGLLELDPSKLKPDER---- 595

  Fly   699 AAAHPHHHQSHHQGQVHQSDSSENSASKKIVDKLKHDVKGFRNVLKKSRTSRKSDESLEMQPLHN 763
                                            .|:..|....:.|:..:|  |.::.|..|....
Zfish   596 --------------------------------DLEDRVNRMYSTLQLMQT--KVNKLLAQQEETR 626

  Fly   764 TSPRGSKILLKR-MSRVRSDEKDADSAEAKDELHDKTPSPIGAGLPLLQRLRLLKEKQDREERAV 827
            .|.|...|.::| :..|..||::.:..|.:.|..::.|..        :|:...|||::::|
Zfish   627 KSIRRRIIEIERFVGEVVEDEEEEEKEETEAEKKEEEPEK--------ERIEEEKEKEEKKE--- 680

  Fly   828 KSTPPQKSPPHSHVTCTLSPQESIQEEP 855
                       ...|..::.:|..:|||
Zfish   681 -----------EEKTKEVTGEEEKREEP 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cngl	NP_001245691.1	Ion_trans	260..481	CDD:278921	92/224 (41%)
		Ion_trans_2	382..476	CDD:285168	48/95 (51%)
		Crp	550..>680	CDD:223736	63/133 (47%)
		CAP_ED	556..668	CDD:237999	55/115 (48%)
cnga1a	NP_001139095.1	Ion_trans	168..381	CDD:278921	86/212 (41%)
		Crp	447..>601	CDD:223736	66/189 (35%)
		CAP_ED	453..569	CDD:237999	55/115 (48%)
		CLZ	569..>625	CDD:293134	13/93 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578357
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1073751at2759
OrthoFinder	1	1.000	-	-		FOG0000167
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750