Protein Alignment Prp5 and DDX23

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_004809.2
• Gene: DDX23 / 9416
• HGNCID: 17347
• Length: 820
• Species: Homo sapiens
• Alignment Length: 950
• Identity: 298/950 - (31%)
• Similarity: 431/950 - (45%)
• Gaps: 275/950 - (28%)

  Fly     7 RDRDRERDRERERERDRERERDRDRERDNRHDSRSRDYDMGKSRNGGGGGAGGGSRNMREDRKRG 71
            :|||....:| ||:|.|..:|:|||:|| |..|.|:|....:||                ||:||
Human     9 KDRDASPSKE-ERKRSRTPDRERDRDRD-RKSSPSKDRKRHRSR----------------DRRRG 55

  Fly    72 KDMISDRGKRDDKRRKCSRSKDYEKDNSPHYRRLDKDRDRDRDRDRQREKEREREKEKEREKEKE 136
                   |.|...|   ||||..|::      |..|:|:||::|||.: |:|:|:|:..| ::|:
Human    56 -------GSRSRSR---SRSKSAERE------RRHKERERDKERDRNK-KDRDRDKDGHR-RDKD 102

  Fly   137 RERD-------------KDRERDRQREKESDSRRAAAAAPLIIPLLSTSCSEEEVEEIDK----- 183
            |:|.             |||:..:..|.|...::..|....:..||:...:|||.|...|
Human   103 RKRSSLSPGRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKA 167

  Fly   184 --------------EEQQRRLEQEMIKRR--------------ERIERWRAER-KRDTKAAVVAP 219
                          ||:||.||:|..||:              ||..|.|.|| :|:|..
Human   168 EREAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNG----- 227

  Fly   220 SLVNSAKKWSLEDESEEDDSNPAPPLDSGKKDAEPDSPPSK-FHSIRKRFDDDVVESKFSPVKRP 283
                        :|.||           |::....:...|| .|:|::|:
Human   228 ------------NEDEE-----------GRQKIREEKDKSKELHAIKERY--------------- 254

  Fly   284 TFSKSFGKLGIGLATKAEADIKKEPPPVDTKKEIKKKPEPVAAKMEIVEEPTVAAGEKTKKEPEQ 348
                    ||                      .|||:                   .:|:...::
Human   255 --------LG----------------------GIKKR-------------------RRTRHLNDR 270

  Fly   349 PHVGAKSEPEVEDKPQPEAEPEDEIDPLDAYMQEVNNEMRRVNNFVNPPAKSQGVVILTG---VA 410
            ..|.           :.:|..:..||                   .||..|.:..|.|.|   :|
Human   271 KFVF-----------EWDASEDTSID-------------------YNPLYKERHQVQLLGRGFIA 305

  Fly   411 ------KKKTTTLKKGEVIEQNMDSLEYSSEDELEDIRDTAVNLAMKHRKELAKIDHSSVTYAPF 469
                  :|:..:...|:::|:.. :||   |.|.|:.|      ..|.||:.||.......::.
Human   306 GIDLKQQKREQSRFYGDLMEKRR-TLE---EKEQEEAR------LRKLRKKEAKQRWDDRHWSQ- 359

  Fly   470 RKNFYVEVPELTRMTAADVEKYRSDLEGIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPT 534
                    .:|..||..|...:|.|. .|..||...|.||::|....:....:||:.:.|:::||
Human   360 --------KKLDEMTDRDWRIFREDY-SITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPT 415

  Fly   535 PIQCQAIPAIMSGRDLIGIAKTGSGKTLAFILPMFRHILDQPSM----EDGDGAIAIIMAPTREL 595
            |||.||||..:..||:||:|:||||||.||::|:...|...|.:    |...|..|||:||||||
Human   416 PIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL 480

  Fly   596 CMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRR 660
            ..||.::..||.|.||:|.|.|.||....:|...|:.|.||::.||||:||:|   ..|...|.|
Human   481 AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVL---ENRYLVLSR 542

  Fly   661 VTYVVLDEADRMFDMGFEPQVMRIID-----NVRPD---------------------RQTVMFSA 699
            .|||||||||||.||||||.|.:|::     |.:||                     ||||||:|
Human   543 CTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTA 607

  Fly   700 TFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQHVVILNDDAKFFKLLELLGIYQEAG---SII 761
            |.|..:|.|||..|::|..|.:|......:.|||.|.::::..|..|||.:|    |.|   .||
Human   608 TMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAIL----EQGFDPPII 668

  Fly   762 VFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLDVKDL 826
            :||::::..|:|.:.|.|..|...:||||..|..|:..:.:.|:|...:|:||.||.||:|::|:
Human   669 IFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDV 733

  Fly   827 ILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQS 866
            .:|||||:..:.|||:||.||||||||.|.|.||:|.|.|
Human   734 SMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDS 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	10/91 (11%)
		DEAD-like_helicase_N	454..899	CDD:475120	182/445 (41%)
		KH-I_DDX46	1121..1223	CDD:411901
DDX23	NP_004809.2	RS domain	1..221		75/247 (30%)
		PTZ00121	<4..>351	CDD:173412	118/509 (23%)
		SF-CC1	80..>209	CDD:273721	34/130 (26%)
		Q motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00552	391..419		8/27 (30%)
		SrmB	392..783	CDD:440279	167/388 (43%)
		DEAD box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	549..552		2/2 (100%)