Protein Alignment Prp5 and DBP3

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_011437.3
• Gene: DBP3 / 852802
• SGDID: S000003046
• Length: 523
• Species: Saccharomyces cerevisiae
• Alignment Length: 635
• Identity: 190/635 - (29%)
• Similarity: 303/635 - (47%)
• Gaps: 131/635 - (20%)

  Fly   313 TKKEIKKKPEPVAAKMEIVEEPTVAAGEKTKKE----PEQPHVGAKSEPEVEDKPQ-PEAEPEDE 372
            ||:||..|...|..: |::|:......:|.||:    .::.|...|.|.:.|.:.: ||.|.|.:
Yeast     2 TKEEIADKKRKVVDE-EVIEKKKSKKHKKDKKDKKEKKDKKHKKHKKEKKGEKEVEVPEKESEKK 65

  Fly   373 IDPLDAYMQEVNNEMRRVNNFVNPPAKSQGVVILTGVAKKKTTTLKKGEVIEQNMDSLEYSSEDE 437
            .:|..|...|..                        |..:..|:|.:.::.       ||..|:|
Yeast    66 PEPTSAVASEFY------------------------VQSEALTSLPQSDID-------EYFKENE 99

  Fly   438 L--EDIRDTAVNLAMKHRKELAKIDHSSVTYAPFRKNFYVEVPELTRMTAADVEKYRSDLEGIQV 500
            :  ||..|.|:       :.|...|:.|
Yeast   100 IAVEDSLDLAL-------RPLLSFDYLS------------------------------------- 120

  Fly   501 KGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKTLAFI 565
                    :.:..|..:||          |.||||||..|.|.::||:|::|:|:||||||.||.
Yeast   121 --------LDSSIQAEISK----------FPKPTPIQAVAWPYLLSGKDVVGVAETGSGKTFAFG 167

  Fly   566 LPMFRHILDQPSMEDGDGAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAEL 630
            :|...|:::.....   |...::::|||||..||..::...:..:|::..|||||....||..:|
Yeast   168 VPAISHLMNDQKKR---GIQVLVISPTRELASQIYDNLIVLTDKVGMQCCCVYGGVPKDEQRIQL 229

  Fly   631 KRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRII-DNVRPDRQT 694
            |: ::::|.||||::|:|...|   .:|.:|.|:||||||||.:.|||..:..|| :.....|||
Yeast   230 KK-SQVVVATPGRLLDLLQEGS---VDLSQVNYLVLDEADRMLEKGFEEDIKNIIRETDASKRQT 290

  Fly   695 VMFSATFPRQMEALARRILKKPIEVIVGGRSVVC--KEVEQHVVILNDDAKFFKLLELLGIY--- 754
            :||:||:|:::..||...:..||:|.:|....:.  |.:.|.|.:::...|..||||||..|
Yeast   291 LMFTATWPKEVRELASTFMNNPIKVSIGNTDQLTANKRITQIVEVVDPRGKERKLLELLKKYHSG 355

  Fly   755 -QEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLLIATSVAA 818
             ::...:::|...::.|..:.|:|....|...::||.:.|..|...:.:|||||..||:||.|||
Yeast   356 PKKNEKVLIFALYKKEAARVERNLKYNGYNVAAIHGDLSQQQRTQALNEFKSGKSNLLLATDVAA 420

  Fly   819 RGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRAMDLSGTLI 883
            ||||:.::..|:|...|...||||||.|||||||:.|:|:|..|.::...||.::..::.:...:
Yeast   421 RGLDIPNVKTVINLTFPLTVEDYVHRIGRTGRAGQTGTAHTLFTEQEKHLAGGLVNVLNGANQPV 485

  Fly   884 PAELQALWTEYKALQEAEGKTVHTG-GGFSGKGFKFDEQEFNAAKESKKL 932
            |.:|....|..|       |..|:. |.|    ||    :.:..|:.||:
Yeast   486 PEDLIKFGTHTK-------KKEHSAYGSF----FK----DVDLTKKPKKI 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	21/74 (28%)
		DEAD-like_helicase_N	454..899	CDD:475120	148/451 (33%)
		KH-I_DDX46	1121..1223	CDD:411901
DBP3	NP_011437.3	SrmB	115..470	CDD:440279	141/416 (34%)