Protein Alignment Prp5 and PRP5

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_009796.1
• Gene: PRP5 / 852539
• SGDID: S000000441
• Length: 849
• Species: Saccharomyces cerevisiae
• Alignment Length: 1085
• Identity: 287/1085 - (26%)
• Similarity: 482/1085 - (44%)
• Gaps: 295/1085 - (27%)

  Fly   178 VEEIDKEEQQRRLEQEMIKRRERIERWRAERKRDTKAAVVAPSLVNSAKKWSLEDESEEDDSNPA 242
            :|.||.::...| |..:.:||:::.:|:.::
Yeast     1 METIDSKQNINR-ESLLEERRKKLAKWKQKK---------------------------------- 30

  Fly   243 PPLDSGKKDAEPDSPPSKFHSIRKRFDDDVVESKFSPVKRPTFSKSFGKLGIGLATKAEADIKKE 307
                 .:.||:.:...|:         :|:|.:...           ||......|:.:..:|:|
Yeast    31 -----AQFDAQKEHQTSR---------NDIVTNSLE-----------GKQTTEKFTERQERVKEE 70

  Fly   308 PPPVDTKKEIKKKPEPVAAKMEIVEEPTVAAGEKTK---------KEPEQPHVGA--KSEPEVED 361
            ..  ..|.|.:|..|||:.|      |:....:::|         .:.:...:|.  :|:..::.
Yeast    71 LR--KRKNEFRKSDEPVSVK------PSKKKSKRSKVKKKISFDFSDDDDSEIGVSFRSKEHIQK 127

  Fly   362 KPQPEAEPEDEIDPLDAYMQEVNNEMRRVNNFVNPPAKSQGVVILTGVAKKKTTTLKKGEV--IE 424
            .|    |.::|.||||.:|..:..|  :::|       |:|:             ..:|::  :|
Yeast   128 AP----EHDNEKDPLDEFMTSLKEE--KMSN-------SKGM-------------YDRGDILDVE 166

  Fly   425 QNMDSLEYSSEDELEDIRDTAVNLA----MKHRKELAKIDHSSVTYAPFRKNFYVEVPELTRMTA 485
            ..:..|..:.::::||..|.: |:|    :|.:|.:.:|.:|.....||:||||:|...::.|:.
Yeast   167 DQLFELGGTDDEDVEDNTDNS-NIAKIAKLKAKKRVKQIYYSPEELEPFQKNFYIESETVSSMSE 230

  Fly   486 ADVEKYRSDLEGIQVKGKGCPKPIKTWAQCGVSKKEMEVL-RRLGFEKPTPIQCQAIPAIMSGRD 549
            .:||:.|..|:.|::||.|||||:..|:|.|:|...|.:: .:|.|...||||.||:||||||||
Yeast   231 MEVEELRLSLDNIKIKGTGCPKPVTKWSQLGLSTDTMVLITEKLHFGSLTPIQSQALPAIMSGRD 295

  Fly   550 LIGIAKTGSGKTLAFILPMFRHILDQ-PSMEDGDGAIAIIMAPTRELCMQIGKDIRKFSKS-LGL 612
            :|||:|||||||::::||:.|.:..| |..:...|.:.:|:||||||.:||.:::.||::: ..:
Yeast   296 VIGISKTGSGKTISYLLPLLRQVKAQRPLSKHETGPMGLILAPTRELALQIHEEVTKFTEADTSI 360

  Fly   613 RPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGF 677
            |.||..||:.:.:||.:||||.||:|.||||.||:|..|.|::.:.:|:|:||:|||||:||:||
Yeast   361 RSVCCTGGSEMKKQITDLKRGTEIVVATPGRFIDILTLNDGKLLSTKRITFVVMDEADRLFDLGF 425

  Fly   678 EPQVMRIIDNVRPDRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQHVVIL-NDD 741
            |||:.:|:..||||:|.|:||||||.::.:.|.|:|..||.:.:..:.:|.:.|:|...|. ::|
Yeast   426 EPQITQIMKTVRPDKQCVLFSATFPNKLRSFAVRVLHSPISITINSKGMVNENVKQKFRICHSED 490

  Fly   742 AKFFKLLELL----GIYQEAGS---------------IIVFVDKQENADILLRDLMKASYPCMSL 787
            .||..|::|:    ..:.|..|               .|:||..|...|.:.:.|:.|.....::
Yeast   491 EKFDNLVQLIHERSEFFDEVQSENDGQSSDVEEVDAKAIIFVSSQNICDFISKKLLNAGIVTCAI 555

  Fly   788 HGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAG 852
            |.|....:|...:..||..|..:|:.|.|.:|||:|.::.||:.|:....:..|||..|||.|..
Yeast   556 HAGKPYQERLMNLEKFKREKNSILLCTEVLSRGLNVPEVSLVIIYNAVKTFAQYVHTTGRTARGS 620

  Fly   853 KKGSAYTFITPEQSRYAGDIIRAMDLSGTLIPAELQAL-WTEYKALQEAEGK--------TVHTG 908
            :.|:|.|.:..:      ::..|..||..:...|::|| ..:.|.|||...|        .....
Yeast   621 RSGTAITLLLHD------ELSGAYILSKAMRDEEIKALDPLQAKELQEMSAKFESGMKKGKFRLS 679

  Fly   909 GGFSGKGFKFDEQEFNAAKESKKLQKAALGLADSDDEEDIEQDIDQQIEQIFAAKRTVKDTSAAA 973
            .||.|||.:      |...:.::.|...|.|..:|...|   |::::|
Yeast   680 KGFGGKGLE------NIKSKREEAQNKDLELKKNDKRSD---DLEKKI----------------- 718

  Fly   974 TAAAAAAAAAAAAAAAVSGANPALASAAAQAAAAAAAANIAIAAASAPAAAGGAPSVAMGGALSS 1038
                               :||                            ..|..||:...||..
Yeast   719 -------------------SNP----------------------------REGHDSVSESSALIP 736

  Fly  1039 DKLELAKRLASKINSSKNLDTKGSVVTVEPMIKGPHVTGAAATLLTARTVAEQMAAKLNNKLNYQ 1103
                                                                        :|||:
Yeast   737 ------------------------------------------------------------RLNYE 741

  Fly  1104 PKEDEEGLGPLVGGTTNPFTKYEEELEINDFPQQARWKVTSKEALAQISEYSEAGLTVRGTYVPQ 1168
                      |...:|:....:..::.|||.||..||:.|....|..|...:...:|.:|.:.|:
Yeast   742 ----------LFKESTDGSIIFYAKVYINDLPQIVRWEATKNTTLLFIKHETGCSITNKGKFYPE 796

  Fly  1169 GKNP--PDGERKLYLAIESCSELAVQKAKREITRLIKEELLKLSS 1211
            ||.|  .:.|.||||.||...|..:|.:...:.:.:||.::|.:|
Yeast   797 GKEPKNENDEPKLYLLIEGQDEKDIQLSIELLEQKVKEGVVKAAS 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	23/102 (23%)
		DEAD-like_helicase_N	454..899	CDD:475120	180/468 (38%)
		KH-I_DDX46	1121..1223	CDD:411901	29/93 (31%)
PRP5	NP_009796.1	DEADc_DDX46	244..468	CDD:350711	112/223 (50%)
		SrmB	255..707	CDD:440279	169/463 (37%)
		KH-I_PRP5_like	749..837	CDD:411902	27/87 (31%)