Protein Alignment Prp5 and PRP28

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_010529.3
• Gene: PRP28 / 851830
• SGDID: S000002651
• Length: 588
• Species: Saccharomyces cerevisiae
• Alignment Length: 589
• Identity: 179/589 - (30%)
• Similarity: 292/589 - (49%)
• Gaps: 83/589 - (14%)

  Fly   331 VEEPTVAAGEKTKKEPEQPHVGAKSEP-----EVEDKPQPEAEPEDEIDPLDAYMQEVNNEMRRV 390
            ::...:.||...||..::...|..|:|     :...|.:...|.|:.:.|..:...:|  |:::|
Yeast     5 IDVSQLIAGINKKKGLDENTSGKISKPRFLNKQERSKQERLKENEESLTPTQSDSAKV--EIKKV 67

  Fly   391 N----NFVNPPAKSQGVVILTGVAKKKTTTLKKGEVIEQNMDSLEYS---SEDELED----IRDT 444
            |    :|.|                  .|..||....:||.....:|   |||.|..    :...
Yeast    68 NSRDDSFFN------------------ETNDKKRNPSKQNGSKFHFSWNESEDTLSGYDPIVSTR 114

  Fly   445 AVNLAMKHR--KELAKIDHSSVTYAPFRKNFYVEVPELTRMTAADVEKYRSDLEGIQVKGKGCPK 507
            |::|..|.:  |..|:        :.:....:.| ..|..|...|....:.|. .|..||.....
Yeast   115 AIDLLWKGKTPKNAAE--------SSYMGKHWTE-KSLHEMNERDWRILKEDY-AIVTKGGTVEN 169

  Fly   508 PIKTWAQCGVSKKEM--EVLRRLGFEKPTPIQCQAIPAIMS---GRDLIGIAKTGSGKTLAFILP 567
            |::.|.:..:..:::  .:::.|.|..|||||...||.:.:   .||.:|:|.|||||||||::|
Yeast   170 PLRNWEELNIIPRDLLRVIIQELRFPSPTPIQRITIPNVCNMKQYRDFLGVASTGSGKTLAFVIP 234

  Fly   568 ----MFRHILDQPSMEDGDGAIAIIMAPTRELCMQIGKDIRKFSK------SLGLRPVCVYGGTG 622
                |.|.....||::..||..|:|:||||||..||.|:.:|.:|      :...:.:.:.||..
Yeast   235 ILIKMSRSPPRPPSLKIIDGPKALILAPTRELVQQIQKETQKVTKIWSKESNYDCKVISIVGGHS 299

  Fly   623 ISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIIDN 687
            :.|....|..|.:|:|.||||:||.|   ...:..:::|..:||||||:|.|:|||.||..|:..
Yeast   300 LEEISFSLSEGCDILVATPGRLIDSL---ENHLLVMKQVETLVLDEADKMIDLGFEDQVTNILTK 361

  Fly   688 V------RPDRQTVMFSATFPRQMEALARRILKKPIEVIVG---GRSVVCKEVEQHVVILNDDAK 743
            |      ..:|||:||:||....:|.:|...::||:...:|   |...:.::|.::..  ||:.|
Yeast   362 VDINADSAVNRQTLMFTATMTPVIEKIAAGYMQKPVYATIGVETGSEPLIQQVVEYAD--NDEDK 424

  Fly   744 FFKLLELLGIYQEAGSIIVFVDKQENADILLRDLMK-ASYPCMSLHGGIDQFDRDSTIIDFKSGK 807
            |.||..::..|..  .||:|::.::.||.|.....| .:.....|||...|..|:.::..|::.|
Yeast   425 FKKLKPIVAKYDP--PIIIFINYKQTADWLAEKFQKETNMKVTILHGSKSQEQREHSLQLFRTNK 487

  Fly   808 VRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAGDI 872
            |:::|||:|||||||:.::.||||:.:....:||:||.||||||..:|:|.:|::..:..   .:
Yeast   488 VQIMIATNVAARGLDIPNVSLVVNFQISKKMDDYIHRIGRTGRAANEGTAVSFVSAAEDE---SL 549

  Fly   873 IRAM 876
            ||.:
Yeast   550 IREL 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	11/56 (20%)
		DEAD-like_helicase_N	454..899	CDD:475120	149/448 (33%)
		KH-I_DDX46	1121..1223	CDD:411901
PRP28	NP_010529.3	SrmB	175..559	CDD:440279	137/389 (35%)