Protein Alignment Prp5 and ddx43

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_001072473.1
• Gene: ddx43 / 779928
• XenbaseID: XB-GENE-988016
• Length: 666
• Species: Xenopus tropicalis
• Alignment Length: 713
• Identity: 223/713 - (31%)
• Similarity: 358/713 - (50%)
• Gaps: 102/713 - (14%)

  Fly   230 LEDESEEDDSNP-----------APPLDSGKKDAEPDSPPSKFHSIRKRFDDDVVESKFSPVKRP 283
            :.|..||.||:.           .||.....::.......|:|...|:..||....|:.......
 Frog     1 MSDWEEESDSSSNQAAARYNTPWVPPSKQYSREEPRTKTQSEFCGWREDNDDGGGRSRSEQGSWR 65

  Fly   284 TFSKSFGKLGIGLATKAEADIKKEPPPVDTKKEIKKKPEPVAAKMEIVEEPTVAAGEKTKKEPEQ 348
            .||:..|                ..||..:.:|.:::                 .|.:.:..|..
 Frog    66 GFSRPRG----------------SGPPGASTREFRRR-----------------EGARDQSSPLC 97

  Fly   349 PHVGAKSEPEVEDKPQPEAEPEDE-------IDPLDAYMQEV----NNEMRR-----VNNFVNPP 397
            .|:.:.:..:|..:...:....:|       |:.|| |..||    |:|.::     :::.|...
 Frog    98 FHLDSSAIGQVIGRGGSKIRELEELSGCRIKIEKLD-YDSEVKIYGNSEQQQKAKELIDDIVEQS 161

  Fly   398 AKSQGVVILTGVAKKKTTTLKKGEVIEQNMDSLEYSSEDELEDIRDTAVNLAMKHRKELAKIDHS 462
            .:..|   ..|. :...:..|..:...|...|:.::|      :|:.             |..:.
 Frog   162 ERGPG---FKGF-RSSGSADKSADASFQVKPSINWAS------LREN-------------KSKYE 203

  Fly   463 SVTYA---PFRKNFYVEVPELTRMTAADVEKYRSD-----LEGIQVKGKGCPKPIKTWAQCGVSK 519
            ::.:|   |..|.||.|.||:..|:..:|||:|.:     .:.::.:.:..|.|:..:.......
 Frog   204 AMKWADMPPIAKAFYKESPEVASMSRDEVEKWRKENNNIICDDLKEEKRSIPNPVPRFEDAFHPF 268

  Fly   520 KE-MEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKTLAFILPMFRHILDQP-SMEDGD 582
            .| |..|.:.|||:|||||.||.|.|:.|.||||||:||:|||||::||.|.|:..|| ..|..|
 Frog   269 PEVMSALEKSGFERPTPIQSQAWPVILQGIDLIGIAQTGTGKTLAYLLPGFIHLDLQPIPREQQD 333

  Fly   583 GAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDM 647
            |...:::||||||.:|:..:..|: |..|...:|:|||...:.||.::.:|.:|::.||||:.|:
 Frog   334 GPGMLVLAPTRELALQVKAECSKY-KYKGFESICIYGGGDRNNQINKVTKGVDIVIATPGRLNDL 397

  Fly   648 LAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIIDNVRPDRQTVMFSATFPRQMEALARRI 712
            ...|   ..||:.:||:||||||||.|||||||:|:|:.::||||.|:|.|||:|..:..||:..
 Frog   398 QMNN---FVNLKSITYLVLDEADRMLDMGFEPQIMKILIDIRPDRHTIMTSATWPDGVRRLAKSY 459

  Fly   713 LKKPIEVIVGGRSVVC-KEVEQHVVILNDDAKFFKLLELLGIYQEAGSIIVFVDKQENADILLRD 776
            ||.|:.|.||...:.. ..|.|||:::.::.|...:|..:...:....:||||.|:..||.|..|
 Frog   460 LKDPMMVYVGTLDLAAVNTVTQHVLVIPEEEKRAFVLHFIDSLKPQDKVIVFVGKKLVADDLSSD 524

  Fly   777 LMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDY 841
            ......|..||||..:|.||:..:.|||.||||:|:||.:|:|||||.|:..|:|:|.|.:.|:|
 Frog   525 FSLQGIPVQSLHGNREQCDREQALDDFKKGKVRILVATDLASRGLDVHDVTHVLNFDFPRNIEEY 589

  Fly   842 VHRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRAMDLSGTLIPAELQAL---WTEYKALQEAE 901
            |||.|||||||:.|.:.|.:|.:..:.||::|..::.:...:|.:|..:   :.::|..:::|
 Frog   590 VHRVGRTGRAGRTGESITLVTRKDWKVAGELISILERANQEVPGDLFDMAERYQQFKIKKDSE 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	12/98 (12%)
		DEAD-like_helicase_N	454..899	CDD:475120	182/458 (40%)
		KH-I_DDX46	1121..1223	CDD:411901
ddx43	NP_001072473.1	KH-I_DDX43_DDX53	95..160	CDD:411858	13/65 (20%)
		SrmB	269..661	CDD:440279	167/388 (43%)