Protein Alignment Prp5 and Ddx41

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_598820.2
• Gene: Ddx41 / 72935
• MGIID: 1920185
• Length: 622
• Species: Mus musculus
• Alignment Length: 633
• Identity: 193/633 - (30%)
• Similarity: 297/633 - (46%)
• Gaps: 90/633 - (14%)

  Fly   320 KPEPVAAKMEIVEEPTVAAGEKTKKEPEQ-----PHV-------------------GAKSEPEVE 360
            :||...|:   .:|.| |.|.:::.|.|.     |:|                   ||..|.:.:
Mouse     5 EPERKRAR---ADEAT-AGGSRSEDEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGATEEEQQD 65

  Fly   361 DKPQPEAEPEDEIDPLDAYMQEVNNEMRRVNNFVNPPAKSQGVVILTGVAKKKTTTLKKGEVIEQ 425
            ...:|..: ||:|                      |......|.:|......|    :|.|..::
Mouse    66 SGSEPRGD-EDDI----------------------PLGPQSNVSLLDQHQHLK----EKAEARKE 103

  Fly   426 NMDSLEYSSEDELEDIRDTAVNLAMKHRKELAKIDHSSVTYAPFRKNFYVEVPELTRMTAADVEK 490
            :....:...|:::  :...|...|:...||:||    .:||....|..:.....:..|:....|:
Mouse   104 SAKEKQLKEEEKI--LESVAEGRALMSVKEMAK----GITYDDPIKTSWTPPRYVLSMSEERHER 162

  Fly   491 YRSDLEGIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAK 555
            .|.... |.|:|.|.|.|||::.:.......:..|::.|...|||||.|.||.|:||||:||||.
Mouse   163 VRKKYH-ILVEGDGIPPPIKSFKEMKFPAAILRGLKKKGILHPTPIQIQGIPTILSGRDMIGIAF 226

  Fly   556 TGSGKTLAFILPMFRHILDQPS---MEDGDGAIAIIMAPTRELCMQIGKDIRKFSKSLG------ 611
            |||||||.|.||:....|:|..   ....:|...:|:.|:|||..|....:..:.:.|.
Mouse   227 TGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPL 291

  Fly   612 LRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMG 676
            ||.....||..:.||:..::.|..::|.||||::|:|   ..::.:|....|:.|||||||.|||
Mouse   292 LRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLL---QKKMVSLDICRYLALDEADRMIDMG 353

  Fly   677 FEPQVMRIIDNVRPDRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQHVVILNDD 741
            ||..:..|....:..|||::||||.|::::..|:..|.||:.:.||.......:|.|.|..:.::
Mouse   354 FEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVKEE 418

  Fly   742 AKFFKLLELLGIYQEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKSG 806
            ||...|||.|  .:....:::|.:|:.:.|.:...|:......:::|||.||.:|...|..|:.|
Mouse   419 AKMVYLLECL--QKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFREG 481

  Fly   807 KVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAGD 871
            |..:|:||.||::|||...:..|:|||:|...|:||||.|||||:|..|.|.|||..     |.|
Mouse   482 KKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINK-----ACD 541

  Fly   872 IIRAMDLSGTL------IPAELQALWTEYKALQEAEGKTVHTGGGFSG 913
            ....|||...|      :|..||.|....:::.:..|:   .|..|.|
Mouse   542 ESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGE---RGCAFCG 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	18/86 (21%)
		DEAD-like_helicase_N	454..899	CDD:475120	162/459 (35%)
		KH-I_DDX46	1121..1223	CDD:411901
Ddx41	NP_598820.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		11/37 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..84		8/55 (15%)
		Q motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00552	181..209		7/27 (26%)
		DEADc_DDX41	192..397	CDD:350709	80/207 (39%)
		DEAD box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	344..347		2/2 (100%)
		SF2_C_DEAD	408..536	CDD:350174	50/129 (39%)