Protein Alignment Prp5 and Tdrd12

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_001355316.1
• Gene: Tdrd12 / 71981
• MGIID: 1919231
• Length: 1277
• Species: Mus musculus
• Alignment Length: 794
• Identity: 147/794 - (18%)
• Similarity: 271/794 - (34%)
• Gaps: 230/794 - (28%)

  Fly   269 DDDVVESKFSPVKRPTFSKSFGKL--------GIGLATKAEADIKKEPPPVDTKKEIKKKPEPVA 325
            :||:|...|:....|..:|:...|        .:..::|....:...|..:..|...:.:.:.:.
Mouse   198 NDDLVAKNFAYYVSPMGNKNLNPLEKPRQSLNSVTCSSKLSPSLTLWPMLLQGKDYHRMENKALN 262

  Fly   326 AKMEIVEEPTVAAGEK--------------------TKK------EPEQPHVGAKSEPEVEDKPQ 364
            .|..:.:.|.:...::                    ||:      :|:.|.|...|: ...:||.
Mouse   263 YKDSLTDSPKMMLEKQQQSLPLKHTEKCTESSVYWPTKRGITIYADPDVPSVSGSSQ-RPNEKPL 326

  Fly   365 PEAEPEDEIDPLDAYMQEVNNEMRRVNNFVNP-PAKSQGVVILTGVAKKKTTTLKKGEVIEQNMD 428
            ...|.:|         .:..|...::..|:|| |.::.|...|..:.|.|..||:.|.|:...::
Mouse   327 RLTEKKD---------CDEKNGCVKLLQFLNPDPLRADGTSDLHQLQKVKLGTLQPGVVLRNRIE 382

  Fly   429 ---SLEYSSEDELEDIRDTAVNLAMKHRKELAKIDHSSVTYAPFRKNFYVEVPELTRMTAADVEK 490
               :||.|.                                                 .:||::|
Mouse   383 PCLTLEKSP-------------------------------------------------LSADLKK 398

  Fly   491 YRSDLEGIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAK 555
                                             .|:|..|..|:.....:.|.|..|.|::.|:.
Mouse   399 ---------------------------------ALQRNKFPGPSHTASYSWPPIARGCDMVVISH 430

  Fly   556 TGSGKTLAFILPMFRHILDQ----PSMEDGDGAIAIIMAPTRELCMQIGKDIRKFS-KSLGLRPV 615
            .|:...|  .||....||..    .|:...:|.:|:|:.|..:....|.:.:..:| .|..|.||
Mouse   431 CGNDPLL--YLPPLLTILQMGGCYKSLPSRNGPLAVIVCPGWKKAQFIFELLGDYSMSSRPLHPV 493

  Fly   616 CVYGGTGISE-QIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFE- 678
            .:..|....| :..:|.||.::||.||..::.:|...|   ....|:.::||||...:|   ||
Mouse   494 LLTIGLHKDEAKNMKLPRGCDVIVTTPHSLLRLLTYRS---LLFLRLCHLVLDEVHMLF---FEA 552

  Fly   679 -PQVMRIIDNVRPD----------RQTVMFSATFPRQMEALARRILKKPIEVIVG-GRSVVCKEV 731
             .|:..|:||.:.:          .|.|.....:.:.::.|.|..:|.|..||.. ..:.:...|
Mouse   553 NEQMFAILDNFKKNVEVEERESAPHQIVAVGVHWNKHIDHLVREFMKDPCVVITALEEAALYGSV 617

  Fly   732 EQHVVILNDDAKFFKLLELLG-IYQEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFD 795
            :|.|.:..:..|...||::|. :..:|...::|.......:.:.:.:...|..|:.:|..: .|:
Mouse   618 QQVVHLCLECEKTSTLLQVLDFVPSQAQKTLIFTCSVAETETVCKVVESNSIFCLKMHKEM-AFN 681

  Fly   796 RDSTIIDFKS----GKVRLLIATSVAARGLDVKDLILVVNYDVP--------------NHYEDYV 842
            ..|.:..:|.    |...:|..|......|.:.|...||::..|              :|::...
Mouse   682 LKSILEQWKKKLSPGSHIVLTLTDDCIPLLAITDATCVVHFSFPSSPKVLGGRLYCMSDHFQSLT 746

  Fly   843 HRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRAMDLSGTLIPAELQALWTEYKALQEAEGKTVHT 907
            .:.....:..||..:...:|...:.:|..|:|.::.:...||:||
Mouse   747 EQGSPAEQGDKKTKSVLLLTERNASHAVGILRYLERADAKIPSEL-------------------- 791

  Fly   908 GGGFSGKGFKFDEQEFNA----AKESKKLQK------AALGLADS----------DDEEDIEQDI 952
                         .||.|    |||.||.::      .|.|....          :.|.||.:.:
Mouse   792 -------------YEFTAGVLEAKEDKKARRPLCPYLKAFGFCKDKRICPDRHHINPEMDIPRKL 843

  Fly   953 DQQIEQIFAAKRTV 966
            ..:...:|...|.:
Mouse   844 SNKTLPVFGHIRVI 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	16/125 (13%)
		DEAD-like_helicase_N	454..899	CDD:475120	94/482 (20%)
		KH-I_DDX46	1121..1223	CDD:411901
Tdrd12	NP_001355316.1	Tudor_TDRD12_rpt1	4..165	CDD:410505
		DEAD-like_helicase_N	396..601	CDD:475120	55/245 (22%)
		SrmB	<507..810	CDD:440279	71/342 (21%)
		Tudor_TDRD12_rpt2	863..985	CDD:410506
		alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.	1138..1242	CDD:469641