Protein Alignment Prp5 and Ddx17

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_951062.1
• Gene: Ddx17 / 67040
• MGIID: 1914290
• Length: 652
• Species: Mus musculus
• Alignment Length: 591
• Identity: 224/591 - (37%)
• Similarity: 321/591 - (54%)
• Gaps: 68/591 - (11%)

  Fly   469 FRKNFYVEVPELTRMTAADVEKYRSDLEGIQVKGKG-CPKPIKTWAQCGVSKKEMEVLRRLGFEK 532
            |.||||||.||:.|:|..:|::.|...| |.|:|.. ||||:..:......:..|:||....|.:
Mouse    51 FEKNFYVEHPEVARLTPYEVDELRRKKE-ITVRGGDVCPKPVFAFHHANFPQYVMDVLMDQHFTE 114

  Fly   533 PTPIQCQAIPAIMSGRDLIGIAKTGSGKTLAFILPMFRHILDQPSMEDGDGAIAIIMAPTRELCM 597
            |||||||..|..:||||::|||:||||||||::||...||..||.:|.|||.|.:::||||||..
Mouse   115 PTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQ 179

  Fly   598 QIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVT 662
            |:.:....:.|...|:..|:|||.....||.:|:||.||.:.||||:||.|  .||: |||||.|
Mouse   180 QVQQVADDYGKCSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFL--ESGK-TNLRRCT 241

  Fly   663 YVVLDEADRMFDMGFEPQVMRIIDNVRPDRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSV- 726
            |:||||||||.|||||||:.:|:|.:||||||:|:|||:|:::..||...|:...::.||...:
Mouse   242 YLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQINVGNLELS 306

  Fly   727 ----------VCKEVEQHVVILNDDAKFFKLLELLGIYQEAGSIIVFVDKQENADILLRDLMKAS 781
                      ||.|.|:       |.|..:|:|.: :.::....|:||:.:...|.|.|.:.:..
Mouse   307 ANHNILQIVDVCMESEK-------DHKLIQLMEEI-MAEKENKTIIFVETKRRCDDLTRRMRRDG 363

  Fly   782 YPCMSLHGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCG 846
            :|.|.:||...|.:||..:.:|:|||..:||||.||:|||||:|:..|:|||.||..||||||.|
Mouse   364 WPAMCIHGDKSQPERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIG 428

  Fly   847 RTGRAGKKGSAYTFITPEQSRYAGDIIRAMDLSGTLIPAELQALWTEYKALQEAEGKTVHTGGGF 911
            ||.|:..||:||||.||...:.|.::|:.::.:...|..:|..| .:::.           |||.
Mouse   429 RTARSTNKGTAYTFFTPGNLKQARELIKVLEEANQAINPKLMQL-VDHRG-----------GGGG 481

  Fly   912 SGKGFKFDEQEFNAAKESKKLQKAALGLADSDDEEDIEQDIDQQIEQIFAAKRTVKD----TSAA 972
            .|||.:...:..::|.....:               .:.:.|:::       |.|||    .|.:
Mouse   482 GGKGGRSRYRTTSSANNPNLM---------------YQDECDRRL-------RGVKDGGRRDSTS 524

  Fly   973 ATAAAAAAAAAAAAAAAVSGANPALASAAAQ------AAAAAAAANIAIAAASAPAAAGGAPSVA 1031
            ....:....|:.|..:.....|.|..:.|.|      ...|||.......|....|...||.|.|
Mouse   525 YRDRSETDRASYANGSGYGSPNSAFGAQAGQYTYAQGTYGAAAYGTSGYTAQEYAAGTYGASSTA 589

  Fly  1032 MGGALS 1037
            ..|..|
Mouse   590 SAGRSS 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653
		DEAD-like_helicase_N	454..899	CDD:475120	194/441 (44%)
		KH-I_DDX46	1121..1223	CDD:411901
Ddx17	NP_951062.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38
		DEAD-like_helicase_N	32..502	CDD:475120	201/474 (42%)
		Q motif	92..120		8/27 (30%)
		DEAD box	246..249		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..652		5/11 (45%)
		Interaction with YAP1. /evidence=ECO:0000250|UniProtKB:Q92841	641..649