Protein Alignment Prp5 and Ddx21

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_062426.2
• Gene: Ddx21 / 56200
• MGIID: 1860494
• Length: 851
• Species: Mus musculus
• Alignment Length: 1052
• Identity: 261/1052 - (24%)
• Similarity: 415/1052 - (39%)
• Gaps: 311/1052 - (29%)

  Fly   169 LSTSCSEEEVEEIDKEEQQRRLEQEMIKRRERIERWRAERKRDTKAAVVAPSLVNSAKKWSLEDE 233
            |.:..:||.:|.:.|..:          ::.|.|:.:::.:..|:....|.|  :.|||.:.:..
Mouse    11 LGSDGAEESMETLPKPSE----------KKTRKEKTKSKTEEATEGMEEAVS--SKAKKTNKKGP 63

  Fly   234 SEEDDSNPAPPLDSGKKDAEPDSPPSKFHSIRKRFDDDVVESKFSPVKRPTFSKSFGKLGIGLAT 298
            | |||.:|.....:.|::.||.             ||....||.|..|:....|
Mouse    64 S-EDDVDPPKSRKAKKQEEEPQ-------------DDTASTSKTSKKKKEPLEK----------- 103

  Fly   299 KAEADIKKEPPPVDTKKEIKKKPE------PVAAKMEIVEEPTVAAGEKT---KKEPEQPHVGAK 354
              :||       .:||:.|.::|.      |...||:..:|....||||:   |....||
Mouse   104 --QAD-------SETKEIITEEPSEEEADMPKPKKMKKGKEANGDAGEKSPKLKNGLSQP----- 154

  Fly   355 SEPEVEDKPQPEAEPEDEIDPLDAYMQEVNNEMRRVNNFVNPPAKSQGVVILTGVAKKKTTTLKK 419
            ||.|. |.|:|:...:.         :|.|                       |.|.:|:..||.
Mouse   155 SEEEA-DIPKPKKMKKG---------KEAN-----------------------GDAGEKSPKLKN 186

  Fly   420 GEVIEQNMDSLEYSSEDELEDIRDTAVNLAMKHRKELAKIDHSSVTYAPFRKNFYVEVPELTRMT 484
            |         |...||:|:    |......||..||.:   ..:...:|..|: .:..|...:..
Mouse   187 G---------LSQPSEEEV----DIPKPKKMKKGKEAS---GDAGEKSPRLKD-GLSQPSEPKSN 234

  Fly   485 AADV--EKYRSDLEGIQVKGKGCPKPIK--TWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIM 545
            ::|.  |:..|:.|      |..|...|  .::...:|::.:::|:..|.....|||.:....:.
Mouse   235 SSDAPGEESSSETE------KEIPVEQKEGAFSNFPISEETVKLLKARGVNFLFPIQAKTFHHVY 293

  Fly   546 SGRDLIGIAKTGSGKTLAFILPMFRHILDQPSMED---GDGAIAIIMAPTRELCMQIGKDIRKFS 607
            ||:|||..|:||:|||.:|.:|:...:  |..:::   |.....:::||||||..|:.||....:
Mouse   294 SGKDLIAQARTGTGKTFSFAIPLIEKL--QGGLQERKRGRAPQVLVLAPTRELANQVSKDFSDIT 356

  Fly   608 KSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRM 672
            |.|.:  .|.||||....||..::.|.:|:|.||||:.|.|  .:|:: :|.::.:|||||.|:|
Mouse   357 KKLSV--ACFYGGTPYGGQIERMRSGIDILVGTPGRIKDHL--QNGKL-DLTKLKHVVLDEVDQM 416

  Fly   673 FDMGFEPQVMRII---------DNVRPDRQTVMFSATFPRQMEALARRILKKPIEVI--VGGR-- 724
            .||||..||..|:         ||    .||::||||.|..:..:|::.:|...|.:  :|.:
Mouse   417 LDMGFADQVEEILCVAYKKDSEDN----PQTLLFSATCPHWVFNVAKKYMKSTYEQVDLIGKKTQ 477

  Fly   725 ---------SVVCKEVEQHVVILNDDAKFFKLLELLGIYQ-EAGSIIVFVDKQENADILLRDLMK 779
                     ::.|...|:..||          .:::.:|. ..|..|:|.:.:::|..|.::..
Mouse   478 KAAITVEHLAIKCHWTERAAVI----------GDVIRVYSGHQGRTIIFCETKKDAQELSQNTC- 531

  Fly   780 ASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHR 844
            ......||||.|.|..|:.|:..|::|...:|:||:|||||||:.::.|||....|...|.|:||
Mouse   532 IKQDAQSLHGDIPQKQREITLKGFRNGNFGVLVATNVAARGLDIPEVDLVVQSCPPKDVESYIHR 596

  Fly   845 CGRTGRAGKKGSAYTFITPEQSRYAGDIIRAMDLSGTLIPAELQALWTEYKALQEAEGKTVHTGG 909
            .|||||||:.|....|...::                    |.|....|.||
Mouse   597 SGRTGRAGRTGVCICFYQNKE--------------------EYQLAQVEQKA------------- 628

  Fly   910 GFSGKGFKFDEQEFNAAKE-SKKLQKAALGLADSDDEEDI---EQDIDQQIEQIFAAKRTVKDTS 970
                 |.||......:|.| .|...|.|:.|.||.....|   :|..::.||:
Mouse   629 -----GIKFKRIGVPSATEIIKASSKDAIRLLDSVPPTAISHFKQSAEKLIEE------------ 676

  Fly   971 AAATAAAAAAAAAAAAAAAVSGANPALASAAAQAAAAAAAANIAIAAASAPAAAGGAPSVAMGGA 1035
                                .||..|||:|.|.                            :.||
Mouse   677 --------------------KGAVEALAAALAH----------------------------ISGA 693

  Fly  1036 LSSDKLELAKRLASKINSSKNLDTKGSVVTVEPMIKGPHVTGAAATLLTARTVAEQMAAKLNNKL 1100
            .|.|:..|       |||.....|    :.:...|:.|:::.|...|  ...:.|.:.||:...:
Mouse   694 TSVDQRSL-------INSQAGFVT----MILRCSIEMPNISYAWKEL--KEQLGESIDAKVKGMV 745

  Fly  1101 NYQPKEDEEGLGPLVGGTTNPFTKYEEELEINDFPQQARWKVTSKEALAQISEYSEAGLTVRGTY 1165
            ..:.|     ||......|...|:.:|:     :....||::|.                  .|.
Mouse   746 FLKGK-----LGVCFDVRTEAVTEIQEK-----WHDSRRWQLTV------------------ATE 782

  Fly  1166 VPQGKNPPDGER 1177
            .|:.:.||||.|
Mouse   783 QPELEGPPDGYR 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	23/100 (23%)
		DEAD-like_helicase_N	454..899	CDD:475120	141/474 (30%)
		KH-I_DDX46	1121..1223	CDD:411901	12/57 (21%)
Ddx21	NP_062426.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..260		78/355 (22%)
		3 X 37 AA tandem repeats	117..227		37/164 (23%)
		Q motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00552	258..286		5/27 (19%)
		SrmB	260..646	CDD:440279	134/445 (30%)
		DEAD box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	411..414		2/2 (100%)
		GUCT_RHII_Gualpha_beta	689..781	CDD:240593	25/160 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	783..851		6/12 (50%)
		AdoMet_MTases	794..>840	CDD:473071	1/1 (100%)
		3 X 5 AA repeats	807..833