DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6227 and ddx42

DIOPT Version :9

Sequence 1:	NP_573020.2	Gene:	CG6227 / 32464	FlyBaseID:	FBgn0030631	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_001032894.2	Gene:	ddx42 / 503932	ZFINID:	ZDB-GENE-050706-53	Length:	908	Species:	Danio rerio

Alignment Length:	852	Identity:	286/852 - (33%)
Similarity:	442/852 - (51%)	Gaps:	115/852 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 PTFSKSFGKLGIGLATKAEADIKKEPPPVDTK-----------------KEIKKKPEPVAAKMEI 330
            |:..:.||..|..|||.     |||.|.:..|                 :::....:....:...
Zfish     8 PSGKRGFGFGGFALATG-----KKEEPHLPQKAHSSFGGTGPSGGYGKNQQLSSFYKIGTKRANF 67

  Fly   331 VEEPTVAAGEKTKKEPEQPHVGAKSEPEVEDKPQPEA-------EPEDEIDPLDAYMQEVNN--- 385
            .||......::.:...:.|::.|::.|   .:.|.::       ..:.|.|||||:|.||.:
Zfish    68 DEENAYFEDDEEESTADLPYIPAENSP---TRKQFQSGGGGGGGGSDSEDDPLDAFMAEVEDQAA 129

  Fly   386 -EMRRVNNFVNPPAKSQGVVILTGVAKKKTTTLKKG--EVIEQNMDSLEY------------SSE 435
             :|:::..                  |:|...:.||  :.||:..|...|            :.|
Zfish   130 KDMKKLEE------------------KEKEKKMAKGIRDDIEEEDDQEAYFRYMAENPTAGLTQE 176

  Fly   436 DELEDI-RDTAVN-LAMKHRK---ELAKIDHSSVTYAPFRKNFYVEVPELTRMTAADVEKYRSDL 495
            :|.|:: .|:..| :|...:|   .|..||||.:.|:||.||||.|..|::.:|.|:|.:.|..|
Zfish   177 EEEEEVDYDSDGNPIAPTTKKIIMPLPPIDHSEIDYSPFEKNFYNEHEEISSLTGAEVVELRRKL 241

  Fly   496 EGIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGK 560
             .::|.|...|||..::|..|..::.|..:|:..:.:|||||||.:|..:||||.||||||||||
Zfish   242 -NLKVSGAAPPKPATSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPIALSGRDAIGIAKTGSGK 305

  Fly   561 TLAFILPMFRHILDQPSMEDGDGAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVCVYGGTGISE 625
            |.|||.|:..||:||..:|.|:|.||:|:.||||||.||..:.::|.|:.|||.|.||||..:.|
Zfish   306 TAAFIWPILVHIMDQKELEPGEGPIAVIVCPTRELCQQIHAECKRFGKAYGLRSVAVYGGGSMWE 370

  Fly   626 QIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIIDNVRP 690
            |...|:.||||:||||||:||.:   ..:.|:|:|||::|.||||||||||||.||..|..:|||
Zfish   371 QAKALQEGAEIVVCTPGRLIDHV---KKKATSLQRVTFLVFDEADRMFDMGFEYQVRSIASHVRP 432

  Fly   691 DRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQHVVIL-NDDAKFFKLLELLGIY 754
            ||||::|||||.:::|.|||.||..||.|:.|......:::.|.|.:| :...|:..|...|..:
Zfish   433 DRQTLLFSATFRKKIEKLARDILVDPIRVVQGDIGEANEDITQIVEVLQSGQDKWGWLTRRLVEF 497

  Fly   755 QEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLLIATSVAAR 819
            ..|||::|||.|:.|.:.|..:|::..|....|||.:||.:|:..|.|||...:.:|:||.||||
Zfish   498 TSAGSVLVFVTKKANCEELATNLIQEGYSLGLLHGDMDQSERNKVIADFKKKNLPVLVATDVAAR 562

  Fly   820 GLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRAMD-----LS 879
            |||:..:..||||||....:.:.||.|||||||:||.|||.:|.:.:.:|||::|.::     :|
Zfish   563 GLDIPSIRTVVNYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTTKDTSFAGDLVRNLEGANQSVS 627

  Fly   880 GTLIPAELQALWTEYKALQEAEGKTVHTGGG------FSGKGFKFDEQ---EFNAAKESKKLQKA 935
            ..|:...:|..|......:..:||.::.|||      ..|.|.:..|:   ...||..:.:..|.
Zfish   628 KDLLDLAMQNPWFRKSRFKGGKGKKINIGGGGLGYRERPGLGSECSERSGGSIAAALGNYETFKP 692

  Fly   936 ALGLADSDDEEDIEQDIDQQIEQIFAAKRTVKDTSAAATAAAAAAAAAAAAAAAVSGA------- 993
            :.| |..|....::|....|.:..|.|...|.......:::::...:|.:.::..:||
Zfish   693 STG-AMGDRMSALKQAFQAQYKNHFVAASGVPPKLTTKSSSSSGWTSAGSLSSLPTGAPEGPDRP 756

  Fly   994 ----NPALASAAAQAAAAAAAANIAIAAASAPAAAGGAPSVAMGGALSSDKLELAKRLASKINSS 1054
                :|:.:|:.:.....|..:.|.::..|   :||...|::...:.||.|        ....|.
Zfish   757 HLSFSPSSSSSFSMPPPPALTSGIKMSGFS---SAGTLSSISDSYSSSSSK--------EPSRSE 810

  Fly  1055 KNLDTKG 1061
            ::.|.:|
Zfish   811 RHSDDRG 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6227	NP_573020.2	SrmB	482..967	CDD:223587	211/499 (42%)
		DEADc	516..719	CDD:238167	114/202 (56%)
		HELICc	733..860	CDD:238034	56/127 (44%)
ddx42	NP_001032894.2	DEADc	257..461	CDD:238167	115/206 (56%)
		DEXDc	270..476	CDD:214692	114/208 (55%)
		HELICc	472..603	CDD:238034	56/130 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D146665at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920