Protein Alignment Prp5 and ais

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_649009.1
• Gene: ais / 39979
• FlyBaseID: FBgn0036754
• Length: 594
• Species: Drosophila melanogaster
• Alignment Length: 675
• Identity: 178/675 - (26%)
• Similarity: 294/675 - (43%)
• Gaps: 153/675 - (22%)

  Fly   336 VAAG----EKTKKEPE-----QPHVGAKSEPEVEDKPQPEAEPEDEIDPLDAYMQEVNNEMRRVN 391
            :.||    :|:||||.     ||      .|||....:|....|.:.|..|.      .|.|.::
  Fly    10 ITAGVRFTKKSKKEPSSKQQLQP------LPEVSKHEEPVKSEESDKDDEDI------TEFRLLD 62

  Fly   392 -NFVNPPAKSQGVVILTGVAKKKTTTLKKGEVIEQNMDSLEYSSEDELEDIRDTAVNLAMKHRKE 455
             :..|.|.:.:       ..|:||.:.|:.|:            :...|:..:|
  Fly    63 GDSSNQPKRKK-------PKKEKTLSPKELEI------------QKAAEEANET----------- 97

  Fly   456 LAKIDHSSVTYAPFRKNFYVEVPELTRMTAADVEKYRSDLEGIQVKGKGCPKPIKTWAQCGVSKK 520
                          ||.:                       ||:|.||..|.|:.::   |...:
  Fly    98 --------------RKQY-----------------------GIRVLGKNVPPPVDSF---GTLTR 122

  Fly   521 EMEVLRRL-------GFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKTLAFILPMFRHILDQPSM 578
            :.::|.||       .|:.|||||.||:|.::..|.|:..|.|||||||||:.|    |::....
  Fly   123 DFKMLPRLQQNLLSRNFDHPTPIQMQALPVLLQRRALMACAPTGSGKTLAFLTP----IINGLRA 183

  Fly   579 EDGDGAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAE------II 637
            ....|..|:::||||||..||.::..:.::..|||...:   :.:||  |:.|.|||      |:
  Fly   184 HKTTGLRALVLAPTRELAQQIYRECAELTRETGLRTHFI---SKVSE--AKQKHGAECKQRYDIL 243

  Fly   638 VCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMG---FEPQVMRIIDNV-----RPDRQT 694
            |.||.| :..|......:.:|..|.:.|||||||:.:.|   |:.|    :|::     .|.:..
  Fly   244 VSTPNR-VRFLLQQEPPLLDLSHVEWFVLDEADRLMEEGQNNFKEQ----LDDIYAACSNPTKCV 303

  Fly   695 VMFSATFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQHVVILNDDAKFFKLLELLGIYQEA-- 757
            ..||||:...:...|.|.||..:.:.:|.::...:.|:|.::.:..:..  ||:.:..:.::.
  Fly   304 AFFSATYTVPVAKWALRHLKNLVRITIGVQNSATETVQQELLFVGSEGG--KLVAIRDLVRQGLQ 366

  Fly   758 GSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLD 822
            ..::|||..:|.|..|..:|:........:|....|..||:.:..|:.|.:.:||.|.:..||:|
  Fly   367 PPVLVFVQSKERAKQLFEELLYDGINVDVIHAERSQHQRDNCVKAFREGSIWVLICTELMGRGID 431

  Fly   823 VKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRAMDLSGTLIPAEL 887
            .|.:.||:|||.|.....|:||.|||||||:.|.|.||.|.|.:.....|...:..||..:|..:
  Fly   432 FKGVNLVINYDFPPTTISYIHRIGRTGRAGRPGRAITFFTQEDTSNLRGIALIIKNSGGTVPEYM 496

  Fly   888 QALWTEYKALQEAEGK----------TVHTGGGFSGKGFKFDEQEFNAAKESKKLQKAALGLADS 942
                .:.|.::::|.|          .:.|......||   ||:.     :|.||:|........
  Fly   497 ----LQMKKVRKSEAKMRAKKPLDREDISTKIRPETKG---DEKH-----KSTKLKKVERTEKIL 549

  Fly   943 DDEEDIEQDIDQQIEQIFAAKRTVK 967
            .:.:..|:|::.:.:::...|..:|
  Fly   550 KNRKGYEKDLNSKQKKLGNIKTELK 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	16/55 (29%)
		DEAD-like_helicase_N	454..899	CDD:475120	136/467 (29%)
		KH-I_DDX46	1121..1223	CDD:411901
ais	NP_649009.1	SrmB	123..538	CDD:440279	134/442 (30%)