DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6227 and Dbp73D

DIOPT Version :9

Sequence 1:	NP_573020.2	Gene:	CG6227 / 32464	FlyBaseID:	FBgn0030631	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster

Alignment Length:	833	Identity:	178/833 - (21%)
Similarity:	292/833 - (35%)	Gaps:	282/833 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 QEVNNEMRRVNNFVNPPAKSQG-----VVILTGVAKKKTTTLKKGEVIEQNMDSLEYSSEDELED 440
            |..|||...:...:...||.:.     .|:.|.:.:|:|:.:|:.|..|:.::    ..|..||.
  Fly    21 QGTNNEDEILQKLLKKAAKRKRKHEAIEVVETPILEKETSDVKESESKEEQVE----EPEKPLEV 81

  Fly   441 IRDTAV-----------NLAMKHRKELAKID----HSSV----TYAPFRKNFYVEVPELTRMTAA 486
            :::..|           :.|.|.:|...::.    |.::    :..|..     |||....:...
  Fly    82 VQEEDVPSNEFQVLGGDDSAAKKKKVQMQLPNWLAHPTIIEGGSLQPEE-----EVPASEAIDQL 141

  Fly   487 D-VEKYRSDLEGIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSG--- 547
            | :|||                      .|       :.|:::..::..|:|.|.||.|:..
  Fly   142 DYLEKY----------------------TC-------QALKQMKIKRLFPVQKQVIPWILEAHAK 177

  Fly   548 ------RDLIGIAKTGSGKTLAFILPMFRHILDQPSMEDGDGAIAIIMAPTRELCMQIGKDIRKF 606
                  ||:...|.|||||||||.:|:.:.:..:...:    ..|:::.|..||.:|:.:.|.:.
  Fly   178 PPPFRPRDICVSAPTGSGKTLAFAIPIVQLLSQRVDCK----VRALVVLPVAELALQVYRVISEL 238

  Fly   607 SKSLGLRPVCVYGG----TGISEQIAELKRG-----AEIIVCTPGRMIDMLAANSGRVTNLRRVT 662
            .....|. ||:...    ....|::.|..:|     |:|:|.||||::|.|.|..|..  |:.:.
  Fly   239 CSKTELE-VCLLSKQHKLEDEQEKLVEQYKGKYYSKADIVVTTPGRLVDHLHATKGFC--LKSLK 300

  Fly   663 YVVLDEADRMFDMGFEPQVMRIIDNVR--------------------------PDRQTVMFSATF 701
            ::|:|||||:.|..|:..:..:..:|:                          |.:  ::||||.
  Fly   301 FLVIDEADRIMDAVFQNWLYHLDSHVKETTDQLLAGTQAPLCYAELQASFGKQPHK--LLFSATL 363

  Fly   702 PRQMEALA----------RRILKKPI-----------EVIVG-----GRSVVCKEVEQHVVILND 740
            .:..|.|.          ..:|..|:           |.:..     ||.....|:.:...:...
  Fly   364 SQDPEKLQDLRLFQPRLFATVLTMPVLKDATEEGADTEALTDPGQFVGRYTTPAELTEQYCVTEL 428

  Fly   741 DAKFFKLLELLGIYQEAGSIIVFVDKQENA---DILLRDL-MKASYPCMSLHGGIDQFDRDSTII 801
            ..|...:..|:..|:.. ..:.|.:..:.|   ..:|:.| .|.|.....|.|.:....|:..:.
  Fly   429 RLKPLTVFALVEKYKWK-RFLCFTNSSDQATRLTFVLKVLFQKYSTKVSELSGNLSAKVRNERLR 492

  Fly   802 DFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQS 866
            ||.:||:..||.:...|||:||.|:.:|::|:.|.|...|:||.|||.|||:||:|.|.:|
  Fly   493 DFAAGKINGLICSDALARGIDVADVDVVLSYETPRHITTYIHRVGRTARAGRKGTAVTVLT---- 553

  Fly   867 RYAGDIIRAMDLSGTLIPAELQALWTEYKALQEAEGKTVHTGGGFSGKGFKFDEQEFNAAKESKK 931
                                                                 ||:....|  |.
  Fly   554 -----------------------------------------------------EQDMTLFK--KI 563

  Fly   932 LQKAALGLADSDDEEDIEQDIDQQIEQIFAAKRTVKDTSAAATAAAAAAAAAAAAAAAVSGANPA 996
            |..|..||.     |:|....|.:|:.....|.                |.|...:..|...|..
  Fly   564 LSDANKGLG-----EEIHVSPDIEIQHAVEYKE----------------ALAGLRSEKVKNKNQK 607

  Fly   997 LASAAAQAAAAAAAANIAIAAASAPAAAGGAPSVAMGGALSSDKLELAKRLASKIN-----SSKN 1056
            :|.....|..|.........|...|                   |.|.::|..|.|     |.|:
  Fly   608 MAEKNRVATKALIHKKQEETATVRP-------------------LTLMEKLQIKANEIVQSSKKS 653

  Fly  1057 LDTKGSVVTVEPMIKGPHVTGAAATLLTARTVAEQMAAKLNNKLNYQPKEDEE 1109
            .:||.|                       :|.|:        |..|||||.::
  Fly   654 SETKNS-----------------------KTKAD--------KTKYQPKETKK 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6227	NP_573020.2	SrmB	482..967	CDD:223587	126/559 (23%)
		DEADc	516..719	CDD:238167	62/267 (23%)
		HELICc	733..860	CDD:238034	40/130 (31%)
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	129/576 (22%)
		DEAD	162..370	CDD:278688	58/216 (27%)
		HELICc	418..551	CDD:238034	41/133 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451474
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030