DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6227 and Gem3

DIOPT Version :9

Sequence 1:	NP_573020.2	Gene:	CG6227 / 32464	FlyBaseID:	FBgn0030631	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_001261678.1	Gene:	Gem3 / 39195	FlyBaseID:	FBgn0011802	Length:	1028	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	130/483 - (26%)
Similarity:	230/483 - (47%)	Gaps:	77/483 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 PKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKTLAFILPM-- 568
            |..:||:.:..:.:..:..|:|..|..||.||..|||..::..|||..:|:|:||||.:::.:
  Fly    21 PGQVKTFEELRLYRNLLNGLKRNNFVTPTKIQAAAIPMALAKMDLIIQSKSGTGKTLIYVIAVVQ 85

  Fly   569 -FRHILDQPSMEDGDGAIAIIMAPTRELCMQIG-------KDIRKFSKSLGLRPVCVYGGTGISE 625
             |...::||.        |:|:.|||||.:|:.       |..|.|..|      ...|||.:::
  Fly    86 SFNPNINQPH--------AMIVVPTRELAIQVQDTFFHLCKSFRDFKCS------AFIGGTDVAK 136

  Fly   626 QIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFD-MGFEPQVMRIIDNVR 689
            ....:.. :.:|:.||||::.:.   ..||.::.::..:||||||:::. ...:..|.::|:.:.
  Fly   137 DRKRMNE-SRVIIGTPGRLLHLY---ENRVFDVSKLRLLVLDEADQLYQTKSLQHTVSKLIEAMP 197

  Fly   690 PDRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQHVVIL---NDDAKFFKL-LEL 750
            .:||.:..|||:.:.::....:::.||:.:....|:.|...:.|.|..|   |:..:..:| |::
  Fly   198 KNRQIIACSATYDQNLDERLAKVMDKPMLISNSERATVLLGIRQFVYELPQQNNSVEEMRLKLQI 262

  Fly   751 LG------IYQEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVR 809
            ||      .|::|   |:|...|..||.....|..:...|..:.|.::|.:|......:::..:|
  Fly   263 LGQIFNQLPYEQA---IIFASSQMRADSYKNYLTASGIDCHLISGAMEQSERLHVFEGYRNFTMR 324

  Fly   810 LLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAGDIIR 874
            :|:||.:.|||:|.....||:|.|.|..:..|:||.||.||.|.||.|.|||..::...     |
  Fly   325 ILVATDLMARGVDSPHANLVINIDPPQDHVTYLHRIGRAGRFGSKGIAITFIASKKESQ-----R 384

  Fly   875 AMDLSGTLIPAELQALWTEYKALQEAEGKTVHTGGGFSGKGFKF-DEQEFN---AAKESKKLQKA 935
            ..::|..:..|     |:..:..:|.           ....|.| |.:::|   ..||...||:.
  Fly   385 FREMSKKIATA-----WSVLEFPKEP-----------MPNEFNFWDFEKYNFDYYIKEENPLQEM 433

  Fly   936 ALGL----------ADSDDEEDIEQDID 953
            .:.:          |.|.|.|::::|.|
  Fly   434 PMPIKENRSKENVDASSVDLENLQKDQD 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6227	NP_573020.2	SrmB	482..967	CDD:223587	130/483 (27%)
		DEADc	516..719	CDD:238167	59/213 (28%)
		HELICc	733..860	CDD:238034	44/136 (32%)
Gem3	NP_001261678.1	SrmB	24..541	CDD:223587	129/480 (27%)
		P-loop_NTPase	27..228	CDD:304359	59/218 (27%)
		Helicase_C	259..367	CDD:278689	35/110 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451465
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840