DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6227 and CG9143

DIOPT Version :9

Sequence 1:	NP_573020.2	Gene:	CG6227 / 32464	FlyBaseID:	FBgn0030631	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_611467.1	Gene:	CG9143 / 37296	FlyBaseID:	FBgn0034496	Length:	813	Species:	Drosophila melanogaster

Alignment Length:	876	Identity:	204/876 - (23%)
Similarity:	324/876 - (36%)	Gaps:	265/876 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 VDTKKEIKKKPEPV--AAKMEIVEEPTVAAGEKTKKEPEQPHVGAKSEPEVEDKPQPEAEPEDEI 373
            |..|::..|.|:.:  |||     ||.::..|..:|...:.||.:......|.....|.     :
  Fly     2 VQNKQKTAKPPKLLKGAAK-----EPALSKAENWQKVKIKGHVISDDGGGFEGLIGLEV-----L 56

  Fly   374 DPLDAYMQEVNNEMRRVNNFVNPPAKSQGVVILTGVAKKKTTTLKKGEVIEQNMDSLEYSSEDEL 438
            ...||.:  |.:..:|..: .||..:.:        .|||...:.||:..|.:..|.|..||||:
  Fly    57 KDYDASL--VKSSQKRTTS-RNPDRERK--------LKKKKRKVSKGDEEESSESSSESESEDEV 110

  Fly   439 EDIRDTA--VNLAMKH-------------RKELAK----------------IDHSSVTYAPFR-- 470
            .....|:  ..||.:|             ||||.|                .:|::..:|..|
  Fly   111 AVAARTSKKARLAERHAQKMQKLREKREKRKELRKQKKSKGKENDNSEESSDEHAADRFALLRPP 175

  Fly   471 ------------------KNFYVEVPELTRMTAADVEKYRSDLEGIQVKGKGCPKPIKTWAQCGV 517
                              ::...|.|||..::..:.|                  .:..|...||
  Fly   176 PSDDEEEVVKAEDSADQQESTDEEAPELVPISTGEAE------------------DMSAWNGLGV 222

  Fly   518 SKKEMEVLRRLGFEKPTPIQCQAIPAIMSG-RDLIGIAKTGSGKTLAFILPMFRHILD------- 574
            ....:..|...||:.||.||...:||.:.| :|::|.|:|||||||||.:||...|::
  Fly   223 PASILRALGEQGFKTPTQIQALTLPAAIHGKKDILGAAETGSGKTLAFGIPMLAGIMELKQRNIR 287

  Fly   575 ------------QP----------------------SMEDGDG----------AIAIIMAPTREL 595
                        ||                      |.|:.|.          ...:::.|||||
  Fly   288 SGIRKAPKVKGQQPEPAADEHELTPPPEELDHVSGASDEESDAEEQAQRVQTPLYGLVLTPTREL 352

  Fly   596 CMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRR 660
            .:|:...:...:|..|:|...::||..:::|...|::..:|:|.||||:.::.|..:..:..:..
  Fly   353 AVQVKNHLVAAAKYTGIRVAAIFGGLAVAKQERVLRQCPDIVVATPGRLWELYAQGNRHLGKIED 417

  Fly   661 VTYVVLDEADRMFDMG-FEP-----QVMRIIDNVRPDRQTVMFSAT------FPRQMEALARRIL 713
            |:::|:||.|||.:.| ||.     :|:...:..:..||..::|||      .|..|:  .|.:.
  Fly   418 VSFLVIDETDRMVEKGHFEELRSLLKVLNSDEQKKHQRQNFVYSATLTLVHDLPDHMQ--KRNVG 480

  Fly   714 KKPIEVIVGGRSVVCKEVEQHVVILNDDAKFFKLLELLGIYQEAGSIIVFVDKQENADILLRDLM 778
            |:|            |.|:|.|     |.|...|:|.|||.|.  .|:.....|:.|..|....:
  Fly   481 KRP------------KFVKQTV-----DQKIESLIEELGISQP--KIVDITSSQQTAQTLTESRL 526

  Fly   779 KA-------------------------SYPC---------------MSLHGGIDQFDRDSTIIDF 803
            ..                         |..|               :.||..:.|..|...:..|
  Fly   527 LCPIDHKDYHLYYFIQRHPGRTIVFCNSIDCVKRLATLFGLLDCNPLPLHANMIQKQRLKNLERF 591

  Fly   804 KSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQ--- 865
            :.....|||||.|||||||:.::..|::|.||...|:||||.|||.||.|.|....|:.|.:
  Fly   592 RDSPTGLLIATDVAARGLDIPNVEHVIHYQVPRTSENYVHRSGRTARANKHGITVMFMEPGEVKS 656

  Fly   866 --------------------SRYAGDIIRAMDLSGTLIPAELQAL-------WTEYKALQEAEGK 903
                                .|:.|.:...::|:..|...||:..       |.:    :.||..
  Fly   657 YVKLYKTLERTEDLPLFPILERFMGAVRERVNLARDLDKEELKLKRVQSERGWMK----KHAEEM 717

  Fly   904 TVHTGGGFSGKGFKFDEQEFNAAKESKKLQKAALGLADSDDEEDIEQDIDQQIEQ-IFAAKRTVK 967
            .:...|.....|...||..|...:...:|:           .|.:...::..:.| ||....:.|
  Fly   718 DMIIDGYNDESGSDQDEDPFVIERRRNRLR-----------VETVRAQLNALLAQPIFPRGFSFK 771

  Fly   968 --DTSAAATAAAAAAAAAAAAAAAVSGANPA 996
              ::.||..|.:...:|.....||:.....|
  Fly   772 YPNSEAAQLATSHTQSAVETMKAAIEDQKQA 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6227	NP_573020.2	SrmB	482..967	CDD:223587	147/619 (24%)
		DEADc	516..719	CDD:238167	73/266 (27%)
		HELICc	733..860	CDD:238034	49/166 (30%)
CG9143	NP_611467.1	BLVR	<125..191	CDD:283923	9/65 (14%)
		SrmB	201..747	CDD:223587	145/588 (25%)
		P-loop_NTPase	217..465	CDD:304359	69/247 (28%)
		HELICc	531..648	CDD:238034	35/116 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451455
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940