DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6227 and CG32344

DIOPT Version :9

Sequence 1:	NP_573020.2	Gene:	CG6227 / 32464	FlyBaseID:	FBgn0030631	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_612028.4	Gene:	CG32344 / 326208	FlyBaseID:	FBgn0052344	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	776	Identity:	199/776 - (25%)
Similarity:	327/776 - (42%)	Gaps:	143/776 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 RKNFYVEVPEL--------TRMTAADVEKYRSDLE---GIQVKGKGCPKPIKTWAQCGVSKKEME 523
            ||....|:|..        |....||:.|.:|...   |.|..|.|. :.||     |::|:
  Fly     2 RKKQADEIPGFPSLDNDAGTSDRGADILKSKSKKNKSGGFQSMGLGF-ELIK-----GITKR--- 57

  Fly   524 VLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKTLAFILPMFRHILDQPSMEDGDGAIAII 588
                 |::.|||||.:.||.|:.|||::.:||||||||..|::|:|..:   ...|...||.|:|
  Fly    58 -----GYKVPTPIQRKTIPLILEGRDVVAMAKTGSGKTACFLIPLFEKL---QRREPTKGARALI 114

  Fly   589 MAPTRELCMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSG 653
            ::|||||.:|..|.|::..:.:.|:.:.|.||..:..|.:.:....::||.||||.:.:.....
  Fly   115 LSPTRELAVQTYKFIKELGRFMELKSILVLGGDSMDSQFSAIHTCPDVIVATPGRFLHLCVEMD- 178

  Fly   654 RVTNLRRVTYVVLDEADRMFDMGFEPQVMRIIDNVRPDRQTVMFSATFPRQMEALARRILKKPIE 718
              ..|..:.|||.|||||:|:|||..|:...:..:...|||||||||.|:.:...||..|..|:.
  Fly   179 --LKLNSIEYVVFDEADRLFEMGFGEQLNETLHRLPSSRQTVMFSATLPKLLVEFARAGLNDPVL 241

  Fly   719 VIVGGRSVVCKEVEQHVVILNDDAKFFKLLELLG-IYQEAGSIIVFVDKQENADILLRDLMKASY 782
            :.:...|.:...:....:....|.::..|:.||. :.......:||...|.:.:::...|.:|..
  Fly   242 IRLDVESKLPDALALKFLYCRPDDRYTALVVLLKYVIPVQSQTVVFAGTQHHVELISYILTEAGI 306

  Fly   783 PCMSLHGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGR 847
            ...|::..:|...|......|.:.||.:||.|.|||||:|:..|..|||...|...:.:|||.||
  Fly   307 SNASVYSSLDPAARKINTAKFVNKKVSVLIVTDVAARGIDIPSLDFVVNLHFPGKPKLFVHRVGR 371

  Fly   848 TGRAGKKGSAYTFITPEQSRYAGDI---------IRAMDLSGTLIPAELQALWTEYKALQEAEGK 903
            ..|||:.|:||:.::.:.:.:..|:         |......|| ||.:|  |..|:..:.:.: |
  Fly   372 CARAGRTGTAYSIVSTDDTAHLLDLHLFLNRPFNIHDSSALGT-IPQDL--LEEEHLTVTDIK-K 432

  Fly   904 TVHTGGGFSGKGFKFDEQEFNAAKESKKLQKAALGLADSDDEEDIEQDIDQQIEQI-FAAKRTVK 967
            :.|..|..        ....||.|:....:..|            ..|.:.::::| |.|.:.::
  Fly   433 SHHIAGVL--------RTSENAYKKYLSSRPVA------------STDANARVKKIKFFALKPLE 477

  Fly   968 DTSAAATAAAAAAAAAAAAAAAVSGANPALASAAAQAAAAAAAANIAIAAASAPAAAGGAPSVAM 1032
            |...||...|.||.|:.             .|..:||..:||...
  Fly   478 DFFTAAPVLAQAAEASG-------------QSTESQAKVSAAERK-------------------- 509

  Fly  1033 GGALSSDKLELAKRLAS--------KINSSKNLDTKGSVVTVEPMIKGPHVTGAAATLLTARTVA 1089
               |..:|.::..::.|        ::|:::.  :...:|..|..::...|............:.
  Fly   510 ---LQEEKHDILVKMRSFRPGGTVFELNTTQK--STQFIVMKEKRMQHAEVINKFRQQRAEEDID 569

  Fly  1090 EQMAA--KLNNKLNYQPKEDEEGLGPLVGGTTNPFTKYEEELEINDFPQQARWKVTSKEALAQIS 1152
            |:...  .||......|..|||.:.........|......:....|.|::.:.|:.||:
  Fly   570 EEKKTIEALNPSSGRMPTADEEAISSTFNKVVAPKRLQNMDALYKDKPKKKKRKINSKD------ 628

  Fly  1153 EYSEAGLTVRGTYVP---QGKNPPDGERKLYLAIESCSELAVQKAK-----REITRLIKEE 1205
                     ...|||   ..|:..||     |||.: .|...|.|:     |::::.:|.:
  Fly   629 ---------EDHYVPYQSADKHTEDG-----LAINN-FERQAQNAEFSVSDRDLSQEVKHK 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6227	NP_573020.2	SrmB	482..967	CDD:223587	148/498 (30%)
		DEADc	516..719	CDD:238167	77/202 (38%)
		HELICc	733..860	CDD:238034	40/127 (31%)
CG32344	NP_612028.4	DEADc	41..243	CDD:238167	82/221 (37%)
		DEXDc	54..243	CDD:214692	76/202 (38%)
		HELICc	263..384	CDD:238034	40/120 (33%)
		DBP10CT	666..721	CDD:285373	1/9 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451460
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940