Protein Alignment Prp5 and ddx46

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_001019988.2
• Gene: ddx46 / 321948
• ZFINID: ZDB-GENE-030131-667
• Length: 1035
• Species: Danio rerio
• Alignment Length: 1211
• Identity: 613/1211 - (50%)
• Similarity: 766/1211 - (63%)
• Gaps: 197/1211 - (16%)

  Fly    33 RDNRHDSRSRDYDMGKSRNGGGGGAGGGSRNMREDRKRGKDMISDRGKRDDKRRKCSRSKDYEKD 97
            |::|| .|.|....|:|          |||:    :.|..|  |.|.|:||  |..||:
Zfish     3 RESRH-YRKRSSSRGRS----------GSRS----KSRSPD--SKRSKKDD--RTASRT------ 42

  Fly    98 NSPHYRRLDKDRDRDRDRDRQREKEREREKEKEREKEKERERDKDRERDRQREKESDSRRAAAAA 162
               |.|| ::.|.|:|.|.|:|:::|...:::.|.:.:||.|.|.|.|.|.:||..:..:.|...
Zfish    43 ---HSRR-ERSRSRERRRSRERKRQRRSSRDRRRSRSRERRRSKSRSRGRSKEKPENGDQTADKK 103

  Fly   163 PLIIPLLSTSCSEEEVEEIDKEEQ---QRRLEQEMIKRRERIERWRAERKRDTKAAV--VAPSL- 221
            .:          :||.||...|:|   |..||:||.||:||:|:||.|:::.....:  :...|
Zfish   104 KI----------KEEKEEEKPEDQDFDQNTLEEEMRKRKERVEKWREEQRKKAMENIGEIKKELE 158

  Fly   222 -VNSAKKWSLEDESEEDDSNPAPPLDSGKKDAEPDSPPSKFHSIRKRFDDDVVESKFSPVKRPTF 285
             :...|||||||:.::|:..|||        .|||.            ||:
Zfish   159 EMKQGKKWSLEDDDDDDEEAPAP--------VEPDG------------DDE-------------- 189

  Fly   286 SKSFGKLGIGLATKAEADIKKEPPPVDTKKEIKKKPEPVAAKMEIVEEPTVAAGEKTKKEPEQPH 350
                                                          ||...||..:..:..|:..
Zfish   190 ----------------------------------------------EEQDKAAEAEESERMEEEE 208

  Fly   351 VGAKSEPEVEDKPQPEAEPEDEIDPLDAYMQEVNNEMRRVN----NFVNPPAKSQGVVILTGVAK 411
            ||                  :|:|||||||:||..|:::.|    ...|.......|..:..|.|
Zfish   209 VG------------------EEVDPLDAYMEEVKEEVKKFNMGTMKGANDKKGGMSVTKVVTVVK 255

  Fly   412 KKT---TTLKKGEVIEQNMDSLEYSSEDELEDIRDTAVNLAMKHRKELAKIDHSSVTYAPFRKNF 473
            .|.   .|.||||::|.:.|::|||||:|..|::........|.||.|..:||..:.|.||||||
Zfish   256 TKKMPHATKKKGELMENDQDAMEYSSEEEEVDLQTALTGFQTKQRKVLEPVDHQKIQYEPFRKNF 320

  Fly   474 YVEVPELTRMTAADVEKYRSDLEGIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQC 538
            |||||||.||:..:|.:||.:||||.|||||||||||||.|||:|.|.:..|::..:|||||||.
Zfish   321 YVEVPELARMSPEEVSEYRLELEGISVKGKGCPKPIKTWVQCGISMKVLNALKKHNYEKPTPIQA 385

  Fly   539 QAIPAIMSGRDLIGIAKTGSGKTLAFILPMFRHILDQPSMEDGDGAIAIIMAPTRELCMQIGKDI 603
            |||||||||||||||||||||||:||:||||||||||..:.:.:|.:|:||.|||||.:||.|:.
Zfish   386 QAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHILDQRPVGEAEGPLAVIMTPTRELALQITKEC 450

  Fly   604 RKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDE 668
            :||||||.||.||||||||||||||||||||||||||||||||||.||:|||||||||||||:||
Zfish   451 KKFSKSLALRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLGANNGRVTNLRRVTYVVIDE 515

  Fly   669 ADRMFDMGFEPQVMRIIDNVRPDRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQ 733
            ||||||||||||||||:||||||||||||||||||.|||||||||.||:||.||||||||.:|||
Zfish   516 ADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRTMEALARRILSKPVEVQVGGRSVVCSDVEQ 580

  Fly   734 HVVILNDDAKFFKLLELLGIYQEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDS 798
            ||:::.::.||.||||:||.|||.||:|:||||||:||.||:||||||||||||||||||:||||
Zfish   581 HVIVIEEEKKFLKLLEILGHYQEKGSVIIFVDKQEHADGLLKDLMKASYPCMSLHGGIDQYDRDS 645

  Fly   799 TIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITP 863
            .|.|||:|..|||:||||||||||||.|||||||..||||||||||.|||||||.||.||||||.
Zfish   646 IINDFKNGACRLLVATSVAARGLDVKQLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAYTFITE 710

  Fly   864 EQSRYAGDIIRAMDLSGTLIPAELQALWTEYKALQEAEGKTVHTGGGFSGKGFKFDEQEFNAAKE 928
            .|:||:|||::|::|||:.:||||:.|||.:|..|:||||.:.:..|||||||||||.|...|.|
Zfish   711 GQARYSGDILKALELSGSSVPAELEQLWTNFKEQQKAEGKIIKSSSGFSGKGFKFDETEHALANE 775

  Fly   929 SKKLQKAALGLADSDDEEDIEQDIDQQIEQIFAAKRTVKDTSAAATAAAAAAAAAAAAAAAVSGA 993
            .||||||||||.|||| ||...|||:|||.:|.:|:.|||.||..:.:|.:|...:.:.:||||
Zfish   776 RKKLQKAALGLHDSDD-EDTALDIDEQIESMFNSKKRVKDFSAPGSVSAGSAGGVSGSVSAVSG- 838

  Fly   994 NPALASAAAQAAAAAAAANIAIAAASAPAAAGGAPSVAMGGALSSDKLELAKRLASKINSSKNLD 1058
                                 :.:.|.|:|.            :..|||:||:||.:|.:.|||.
Zfish   839 ---------------------LGSLSTPSAG------------NIQKLEIAKKLALRIQAQKNLG 870

  Fly  1059 TKGSVV---TVEPMIKGPHVTGAAATLLTARTVAEQMAAKLNNKLNYQPKE--DEEGLGPLVGGT 1118
            .:...|   ....:::|..:   .|..::|:|:|||.|.|:|.||||.|.|  :||........|
Zfish   871 AEAQDVMQQATNAILRGGTI---IAPSVSAKTIAEQQAEKINAKLNYTPVEKLEEERQAAEAAET 932

  Fly  1119 TNPFTKYEEELEINDFPQQARWKVTSKEALAQISEYSEAGLTVRGTYVPQGKNPPDGERKLYLAI 1183
            ..   :||||||||||||.|||||||||||.:|.|||||.:|:||||.|.||.|.:||||:||||
Zfish   933 VK---RYEEELEINDFPQTARWKVTSKEALQRIGEYSEAAITIRGTYFPPGKEPKEGERKIYLAI 994

  Fly  1184 ESCSELAVQKAKREITRLIKEELLKLSSAHHVFNKGRYKVV 1224
            ||.:||||||||.||||||||||::|.:::...:||||||:
Zfish   995 ESANELAVQKAKAEITRLIKEELIRLQNSYQPTSKGRYKVL 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	15/91 (16%)
		DEAD-like_helicase_N	454..899	CDD:475120	335/444 (75%)
		KH-I_DDX46	1121..1223	CDD:411901	71/101 (70%)
ddx46	NP_001019988.2	Q motif	357..385		15/27 (56%)
		DEAD box	514..517		2/2 (100%)