Protein Alignment Prp5 and Ddx21

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_001032278.1
• Gene: Ddx21 / 317399
• RGDID: 1307306
• Length: 782
• Species: Rattus norvegicus
• Alignment Length: 954
• Identity: 233/954 - (24%)
• Similarity: 374/954 - (39%)
• Gaps: 271/954 - (28%)

  Fly   258 PSKFHSIRKRFDDDVVESKFSPVKRPTFSKSFGKLGIGLATKAEADIKKEPPPVDTKKEIKKKPE 322
            |.|..|..|. :.:..|.....:::|:..|:                :||.|...|.:..:...|
  Rat     2 PGKLRSASKS-ESEGTEESMETLQKPSEKKT----------------RKEKPKSKTDEATEGVEE 49

  Fly   323 PVAAKMEIVEEPTVAAGEKTKKEPEQPHVGAKSEPEVEDKPQPEAEPEDEIDPLDAYMQEVNNEM 387
            ..::|::.|:          ||.|.:..||   .|:.:...:.|.||:|  ||
  Rat    50 AASSKVKAVK----------KKGPSEDDVG---PPKSKKAKKQEEEPQD--DP------------ 87

  Fly   388 RRVNNFVNPPAKSQGVVILTGVAKKKTTTLKKGEVIEQNMDSL---EYSSEDELEDIRDTAVNLA 449
                                  |.|..|:.||.|.:|:...|.   |..:|:..|:..|......
  Rat    88 ----------------------ASKSKTSKKKKEPLEKKAPSAKTKEMKAEEPSEEEADAPKPKK 130

  Fly   450 MKHRKEL-AKIDHSSVTYAPFRKNFYVEVPELTRMTAADVEKYRSDLEGIQVKGKGCPKPIKTWA 513
            .|..||. ..:...|    |..||........:..|.|..|:..::.| |.|:.|.     ..::
  Rat   131 TKKGKEANGDVGEKS----PGLKNGLSHPKPDSSSTQAPGEESETEKE-IPVEQKE-----GAFS 185

  Fly   514 QCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKTLAFILPMFRHILDQPSM 578
            ...:|::.:::|:..|.....|||.:....:.||:|||..|:||:|||.:|.:|:...:  |..:
  Rat   186 NFPISEETVKLLKARGVNFLFPIQAKTFHHVYSGKDLIAQARTGTGKTFSFAIPLIEKL--QGGL 248

  Fly   579 ED---GDGAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCT 640
            ::   |.....:::||||||..|:.||....:|.|.:  .|.||||....||..::.|.:|:|.|
  Rat   249 QERKRGRAPQVLVLAPTRELANQVSKDFSDITKKLSV--ACFYGGTPYGGQIERMRSGIDILVGT 311

  Fly   641 PGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRII---------DNVRPDRQTVM 696
            |||:.|.|  .:|:: :|.::.:|||||.|:|.||||..||..|:         ||    .||::
  Rat   312 PGRIKDHL--QNGKL-DLTKLKHVVLDEVDQMLDMGFADQVEEILCVAYKKDSEDN----PQTLL 369

  Fly   697 FSATFPRQMEALARRILKKPIEVI--VGGR-----------SVVCKEVEQHVVILNDDAKFFKLL 748
            ||||.|..:..:|::.:|...|.:  :|.:           ::.|...|:..||          .
  Rat   370 FSATCPHWVFNVAKKYMKSTYEQVDLIGKKTQKAAITVEHLAIKCHWTERAAVI----------G 424

  Fly   749 ELLGIYQ-EAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLLI 812
            :::.:|. ..|..|:|.:.:::|..|.::.. ......||||.|.|..|:.|:..|::|...:|:
  Rat   425 DVIRVYSGHQGRTIIFCETKKDAQELSQNTC-IKQDAQSLHGDIPQKQREITLKGFRNGNFGVLV 488

  Fly   813 ATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRAMD 877
            ||:|||||||:.::.|||....|...|.|:||.|||||||:.|....|...::
  Rat   489 ATNVAARGLDIPEVDLVVQSCPPKDVESYIHRSGRTGRAGRTGVCICFYQHKE------------ 541

  Fly   878 LSGTLIPAELQALWTEYKALQEAEGKTVHTGGGFSGKGFKFDEQEFNAAKE-SKKLQKAALGLAD 941
                    |.|....|.||                  |.||......:|.| .|...|.|:.|.|
  Rat   542 --------EYQLAQVEQKA------------------GIKFKRIGVPSATEIIKASSKDAIRLLD 580

  Fly   942 SDDEEDI---EQDIDQQIEQIFAAKRTVKDTSAAATAAAAAAAAAAAAAAAVSGANPALASAAAQ 1003
            |.....|   :|..::.||:                                .||..|||:|.|.
  Rat   581 SVPPTAIGHFKQSAEKLIEE--------------------------------KGAVEALAAALAH 613

  Fly  1004 AAAAAAAANIAIAAASAPAAAGGAPSVAMGGALSSDKLELAKRLASKINSSKNLDTKGSVVTVEP 1068
                                        :.||.|.|:..|       |||.....|    :.:..
  Rat   614 ----------------------------ISGATSVDQRSL-------INSQAGFVT----MILRC 639

  Fly  1069 MIKGPHVTGAAATLLTARTVAEQMAAKLNNKLNYQPKEDEEGLGPLVGGTTNPFTKYEEELEIND 1133
            .::.|:::.|...|  ...:.|.:.||:...:..:.|     ||......|...|:.:|:
  Rat   640 SVEMPNISYAWKEL--KEQLGESIDAKVKGMVFLKGK-----LGVCFDVRTEAVTEIKEK----- 692

  Fly  1134 FPQQARWKVTSKEALAQISEYSEAGLTVRGTYVPQGKNPPDGER 1177
            :....||::|.                  .|..|:.:.||:|.|
  Rat   693 WHDSRRWQLTV------------------ATEQPELEGPPEGYR 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	19/91 (21%)
		DEAD-like_helicase_N	454..899	CDD:475120	142/471 (30%)
		KH-I_DDX46	1121..1223	CDD:411901	11/57 (19%)
Ddx21	NP_001032278.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..184		52/257 (20%)
		Q motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00552	182..210		5/27 (19%)
		SrmB	184..570	CDD:440279	134/445 (30%)
		DEAD box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	335..338		2/2 (100%)
		GUCT_RHII_Gualpha_beta	613..705	CDD:240593	24/160 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..782		6/15 (40%)
		AdoMet_MTases	716..>765	CDD:473071	2/3 (67%)
		3 X 5 AA repeats	720..747