Protein Alignment Prp5 and Ddx41

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_001101516.1
• Gene: Ddx41 / 314336
• RGDID: 1311758
• Length: 622
• Species: Rattus norvegicus
• Alignment Length: 635
• Identity: 193/635 - (30%)
• Similarity: 298/635 - (46%)
• Gaps: 90/635 - (14%)

  Fly   318 KKKPEPVAAKMEIVEEPTVAAGEKTKKEPEQ-----PHV-------------------GAKSEPE 358
            :.:||...|:   ..|.| |.|.:::.|.|.     |:|                   ||..|.:
  Rat     3 ESEPERKRAR---TNEAT-AGGSRSEDEDEDDEDYVPYVPLRQRRQLLLQKLLQRRRKGAAEEEQ 63

  Fly   359 VEDKPQPEAEPEDEIDPLDAYMQEVNNEMRRVNNFVNPPAKSQGVVILTGVAKKKTTTLKKGEVI 423
            .:...:|..: ||:|                      |......|.:|......|    :|.|..
  Rat    64 QDSGSEPRGD-EDDI----------------------PLGPQSNVSLLDQHQHLK----EKAEAR 101

  Fly   424 EQNMDSLEYSSEDELEDIRDTAVNLAMKHRKELAKIDHSSVTYAPFRKNFYVEVPELTRMTAADV 488
            :::....:...|:::  :...|...|:...||:||    .:||....|..:.....:..|:....
  Rat   102 KESAKEKQLKEEEKI--LESVAEGRALMSVKEMAK----GITYDDPIKTSWTPPRYVLSMSEERH 160

  Fly   489 EKYRSDLEGIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGI 553
            |:.|.... |.|:|.|.|.|||::.:..:....:..|::.|...|||||.|.||.|:||||:|||
  Rat   161 ERVRKKYH-ILVEGDGIPPPIKSFKEMKLPAAILRGLKKKGILHPTPIQIQGIPTILSGRDMIGI 224

  Fly   554 AKTGSGKTLAFILPMFRHILDQPS---MEDGDGAIAIIMAPTRELCMQIGKDIRKFSKSLG---- 611
            |.|||||||.|.||:....|:|..   ....:|...:|:.|:|||..|....:..:.:.|.
  Rat   225 AFTGSGKTLVFTLPVIMFCLEQEKRLPFSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSS 289

  Fly   612 --LRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFD 674
              ||.....||..:.||:..::.|..::|.||||::|:|   ..::.:|....|:.|||||||.|
  Rat   290 PLLRCALCIGGMSVKEQMETIRHGVHMMVATPGRLMDLL---QKKMVSLDICRYLALDEADRMID 351

  Fly   675 MGFEPQVMRIIDNVRPDRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQHVVILN 739
            ||||..:..|....:..|||::||||.|::::..|:..|.||:.:.||.......:|.|.|..:.
  Rat   352 MGFEGDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQEVEYVK 416

  Fly   740 DDAKFFKLLELLGIYQEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFK 804
            ::||...|||.|  .:....:::|.:|:.:.|.:...|:......:::|||.||.:|...|..|:
  Rat   417 EEAKMVYLLECL--QKTPPPVLIFAEKKADVDAIHEYLLLKGVEAVAIHGGKDQEERTKAIEAFR 479

  Fly   805 SGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYA 869
            .||..:|:||.||::|||...:..|:|||:|...|:||||.|||||:|..|.|.|||..     |
  Rat   480 EGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATTFINK-----A 539

  Fly   870 GDIIRAMDLSGTL------IPAELQALWTEYKALQEAEGKTVHTGGGFSG 913
            .|....|||...|      :|..||.|....:::.:..|:   .|..|.|
  Rat   540 CDESVLMDLKALLLEAKQKVPPVLQVLHCGDESMLDIGGE---RGCAFCG 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	18/88 (20%)
		DEAD-like_helicase_N	454..899	CDD:475120	162/459 (35%)
		KH-I_DDX46	1121..1223	CDD:411901
Ddx41	NP_001101516.1	SrmB	180..562	CDD:440279	143/391 (37%)