DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6227 and Ddx42

DIOPT Version :9

Sequence 1:	NP_573020.2	Gene:	CG6227 / 32464	FlyBaseID:	FBgn0030631	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_001100529.1	Gene:	Ddx42 / 303607	RGDID:	1304909	Length:	929	Species:	Rattus norvegicus

Alignment Length:	832	Identity:	283/832 - (34%)
Similarity:	422/832 - (50%)	Gaps:	94/832 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 FGKLGIGLATKAEADI------------------KKEPPPVDTKKEIKKKPEPVAAKMEIVEEPT 335
            ||...|....|.||.:                  |..||.:.:..:|..|......:....|:.
  Rat    16 FGGFAISAGKKEEAKLPQQSHSAFGAASSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDE- 79

  Fly   336 VAAGEKTKKEPEQPHVGAKSEPEVEDKPQPEAEPEDEIDPLDAYMQEVNN----EMRRVNNFVNP 396
                |:.....:.|::.|::.|..:......|:.:.:.|||:|:|.||.:    :|:|:......
  Rat    80 ----EEDSSNVDLPYIPAENSPTRQQFRSKPADSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKE 140

  Fly   397 PAKSQGV-----------VILTGVAKKKTTTLKKGEVIEQNMDSLEYSSEDELEDIRDTAVNLAM 450
            ....:|:           .....:|:..|.    |.|.|:..|:|||.|:       ...:..:.
  Rat   141 RKNVKGIRDDIEEEDDQEAYFRYMAENPTA----GVVQEEEEDNLEYDSD-------GNPIAPSK 194

  Fly   451 KHRKELAKIDHSSVTYAPFRKNFYVEVPELTRMTAADVEKYRSDLEGIQVKGKGCPKPIKTWAQC 515
            |....|..||||.:.|.||.||||.|..|:|.:|...:...|..| .::|.|...|:|..::|..
  Rat   195 KIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKL-NLRVSGAAPPRPGSSFAHF 258

  Fly   516 GVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKTLAFILPMFRHILDQPSMED 580
            |..::.|..:|:..:.:|||||||.:|..:||||:|||||||||||.|||.||..||:||..:|.
  Rat   259 GFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEP 323

  Fly   581 GDGAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMI 645
            |||.||:|:.||||||.||..:.::|.|:..||.|.||||..:.||...|:.||||:||||||:|
  Rat   324 GDGPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLI 388

  Fly   646 DMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIIDNVRPDRQTVMFSATFPRQMEALAR 710
            |.:   ..:.|||:||:|:|.||||||||||||.||..|..:|||||||::|||||.:::|.|||
  Rat   389 DHV---KKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLAR 450

  Fly   711 RILKKPIEVIVGGRSVVCKEVEQHVVILND-DAKFFKLLELLGIYQEAGSIIVFVDKQENADILL 774
            .||..||.|:.|......::|.|.|.||:. .:|:..|...|..:..:||:::||.|:.||:.|.
  Rat   451 DILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELA 515

  Fly   775 RDLMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYE 839
            .:|.:..:....|||.:||.:|:..|:|||...:.:|:||.|||||||:..:..|:||||....:
  Rat   516 NNLKQEGHNLGLLHGDMDQSERNKVILDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDID 580

  Fly   840 DYVHRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRAMD-----LSGTLIPAELQALWTEYKALQE 899
            .:.||.|||||||:||.|||.:||:.|.:|||::|.::     :|..|:...:|..|......:.
  Rat   581 THTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKG 645

  Fly   900 AEGKTVHTGGGFSGKGFKFDEQEFNAAKESKKLQKAALGLADSDDEEDIEQDIDQQIEQIFAAKR 964
            .:||.::.|||  |.|::               ::..||..:||  .....::....|....:..
  Rat   646 GKGKKLNIGGG--GLGYR---------------ERPGLGSENSD--RGSNNNVMSNYEAYKPSTG 691

  Fly   965 TVKDTSAAATAAAAAAAAAAAAAAAVSGANPALASAAAQAAAAAAAANIAIAAASAPAAAGGAPS 1029
            .:.|...|..||..:...:...||::|......::|.|....:|.:.|      |.|.      :
  Rat   692 AMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGTSTAGASGWTSAGSLN------SVPT------N 744

  Fly  1030 VAMGGALSSDK-LELAKRLASKINSSKNLDTKGSVVTVEPMIKGPHVTGAAA 1080
            .|..|..|.|. :..:.:.....|:|.|:   .|.....|.|....|...|:
  Rat   745 SAQQGHNSPDNPITSSTKNIPGFNNSGNI---SSAPVTYPSIGAQGVNNTAS 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6227	NP_573020.2	SrmB	482..967	CDD:223587	205/490 (42%)
		DEADc	516..719	CDD:238167	116/202 (57%)
		HELICc	733..860	CDD:238034	54/127 (43%)
Ddx42	NP_001100529.1	PRK10590	254..678	CDD:236722	197/445 (44%)
		DEADc	255..459	CDD:238167	117/206 (57%)
		HELICc	470..601	CDD:238034	55/130 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D146665at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920