Protein Alignment CG6227 and prp11

DIOPT Version :9

• Sequence 1: NP_573020.2
• Gene: CG6227 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_587856.1
• Gene: prp11 / 2538936
• PomBaseID: SPCC10H11.01
• Length: 1014
• Species: Schizosaccharomyces pombe
• Alignment Length: 1272
• Identity: 457/1272 - (35%)
• Similarity: 626/1272 - (49%)
• Gaps: 319/1272 - (25%)

  Fly    11 RERDRERERERDRERERDRDRERDNRHDSRSRDYDMGKSRNGGGGGAGGGSRNMREDRKRGKDMI 75
            |.|.|...| |...|||...|:.|:..|.:...|:                        |..|.:
pombe     4 RTRSRSPPR-RSYNRERRDYRKYDDSEDQKGARYN------------------------RYVDDV 43

  Fly    76 SDRGKRDDKRRKCSRSKDYEKDNS-PHYRRLDKDRDRDRDRDRQREKE-------REREKEKERE 132
            |.|..|.|..|. ..|....:||| .|.:...:.|.::|||:..|.|.       |.......|.
pombe    44 SSRRDRHDSFRS-HESNKIRRDNSWKHDKYSYEKRYQERDREYARSKNIPDQYIGRSPRPTSHRH 107

  Fly   133 KEKERERDKDRERDR----------------QREKESDSRRAAAAAPLIIPLLSTSCSEEEVEEI 181
            .| |:|.|...:.|.                :|.:...:.|..|:       ||.|..:.|...:
pombe   108 AE-EKEVDNKTKSDETNPVLQGSATEIKPQPRRSRFDRTERVGAS-------LSVSEIQSENPRV 164

  Fly   182 D--------KEEQQRRLEQ----------EMIKRRERIERWRAERKRDTKAAVVAPSLVNSAKKW 228
            |        :...||..|:          :::.|.||:..|:..:.:.           .::||
pombe   165 DVIPKDKAVENNHQRNAEKPVASDKITDAKLLARLERVRAWKESKAKQ-----------EASKK- 217

  Fly   229 SLEDESEEDDSNPAPPLDSGKKDAEPDSPPSKFHSIRKRFDDDVVESKFSPVKRPTFSKSFGKLG 293
                  ||...|..|.:.:..::|.|.:..|.|...|:
pombe   218 ------EEHKLNTKPQVTAKDQNAMPSTGISGFEINRQ--------------------------- 249

  Fly   294 IGLATKAEADIKKEPPPVDTKKEIKKKPEPVAAKMEIVEEPTVAAGEKTKKEPEQPHVGAKSEPE 358
                 |..:|:|:     :.:..:..:..|....:|..:|        ...:.::..:|.:....
pombe   250 -----KDTSDMKR-----NNRVHMDDEDGPRRMNLEDYQE--------LWDQEDRGMLGNEQAAS 296

  Fly   359 VEDKPQPEAEPEDEIDPLDAYMQEVNNEMRRVNNFVNPPAKSQGVVILTGVAKKKTTTLKKG--- 420
            :|         |||:|||||||..                       |.|.    |.|::.|
pombe   297 ME---------EDEVDPLDAYMAS-----------------------LVGT----TDTIRPGLLN 325

  Fly   421 -EVIEQNMDSLEYSSEDELEDIRDTAVNLAMKH--RKELAKIDHSSVTYAPFRKNFYVEVPELTR 482
             |||:.|.:..|.....|..:..:..:.||.|.  :|::..:|||.:.|..|:|:||||..||..
pombe   326 TEVIDPNANDDERMVISETLEEEENLLALAAKRSKKKDVITVDHSKINYEDFKKDFYVEPEELKN 390

  Fly   483 MTAADVEKYRSDLEGIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSG 547
            ::.|:|::.|:.|:||:::|..||||:.:|:|||:|.:.:.|:..||:||||.||.||||||.||
pombe   391 LSPAEVDELRASLDGIKIRGIDCPKPVTSWSQCGLSAQTISVINSLGYEKPTSIQAQAIPAITSG 455

  Fly   548 RDLIGIAKTGSGKTLAFILPMFRHILDQPSMEDGDGAIAIIMAPTRELCMQIGKDIRKFSKSLGL 612
            ||:||:||||||||:||:|||||||.||..::.|:|.|||||.|||||.:||.::.:.|.|.|.:
pombe   456 RDVIGVAKTGSGKTIAFLLPMFRHIKDQRPLKTGEGPIAIIMTPTRELAVQIFRECKPFLKLLNI 520

  Fly   613 RPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGF 677
            |..|.|||..|.:|||:|||||||:|||||||||:|:||:||||||.|.||:||||||||||:||
pombe   521 RACCAYGGAPIKDQIADLKRGAEIVVCTPGRMIDVLSANAGRVTNLHRCTYLVLDEADRMFDLGF 585

  Fly   678 EPQVMRIIDNVRPDRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQHVVILNDDA 742
            ||||||||:|:|||||||:|||||||.||||||::||||:|:.|||||||..||||.|.:..:::
pombe   586 EPQVMRIINNIRPDRQTVLFSATFPRAMEALARKVLKKPVEITVGGRSVVASEVEQIVEVRPEES 650

  Fly   743 KFFKLLELLG-IYQEAGSI--IVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFK 804
            ||.:|||||| :|.....:  :||||:||:||.||.||||..|...|:|||.||.||||||.|:|
pombe   651 KFSRLLELLGELYNNQLDVRTLVFVDRQESADALLSDLMKRGYTSNSIHGGKDQHDRDSTISDYK 715

  Fly   805 SGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYA 869
            :|...:||||||.|||||||.|.||||||.|||.||||||.|||||||..|.|.|||||||.:||
pombe   716 AGVFDVLIATSVVARGLDVKSLQLVVNYDCPNHMEDYVHRVGRTGRAGHTGVAVTFITPEQEKYA 780

  Fly   870 GDIIRAMDLSGTLIPAELQALWTEYKALQEAEGKTVHTGGGFSGKGFKFDEQEFNAAKESKKLQK 934
            .||.:|:.:|...:|.|||.|.:::....:| ||....||||.|||....::..||   .:|:|:
pombe   781 VDIAKALKMSKQPVPKELQTLASQFLEKVKA-GKEKAAGGGFGGKGLSRLDETRNA---ERKMQR 841

  Fly   935 AALGLADSDDEEDIEQDIDQQ--IEQIFAAKRTVKDTSAAATAAAAAAAAAAAAAAAVSGANPAL 997
            .|.|    :||||:|.:.:.:  :|:|...|.|                           .:|.|
pombe   842 KAYG----EDEEDVETEAEAKSPLEKITPEKST---------------------------GDPTL 875

  Fly   998 ASAAAQAAAAAAAANIAIAAASAPAAAGGAPSVAMGGALSSDKLELAKRLASKINSSKNLDTKGS 1062
            ....|                            |:||
pombe   876 DRVRA----------------------------AVGG---------------------------- 884

  Fly  1063 VVTVEPMIKGPHVTGAAATLLTARTVAEQMAAKLNNKLNYQP----KEDEEGLGPLVGGTTNPFT 1123
                                :.||..|.|.|.  :|||. ||    |.|.:
pombe   885 --------------------IAARAFANQTAQ--SNKLT-QPISIIKTDGD-------------- 912

  Fly  1124 KYEEELEINDFPQQARWKVTSKEALAQISEYSEAGLTVRGTYVPQGKNPPDGERKLYLAIESCSE 1188
            :|:.::||||:||||||.||:...:..::|.:...:|.:|.:...||||..||.||||.||..||
pombe   913 EYKAKMEINDYPQQARWAVTNNTNIVHVTELTGTSITTKGNFYLPGKNPEPGEEKLYLWIEGPSE 977

  Fly  1189 LAVQKAKREITRLIKEEL-LKLSSAHHVFNKGRYKVV 1224
            |.|.:|..|:.||:.|.: ..|...:.....|||.||
pombe   978 LVVNRAITELRRLLLEGINHSLEGGNKPSASGRYTVV 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6227	NP_573020.2	SrmB	482..967	CDD:223587	288/489 (59%)
		DEADc	516..719	CDD:238167	141/202 (70%)
		HELICc	733..860	CDD:238034	79/129 (61%)
prp11	NP_587856.1	SrmB	395..868	CDD:223587	285/480 (59%)
		DEADc	420..628	CDD:238167	145/207 (70%)
		Helicase_C	649..763	CDD:278689	73/113 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	259	1.000	Domainoid score	I377
eggNOG	1	0.900	-	-		E2759_KOG0334
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5430
Inparanoid	1	1.050	695	1.000	Inparanoid score	I105
OMA	1	1.010	-	-		QHG54542
OrthoFinder	1	1.000	-	-		FOG0004627
OrthoInspector	1	1.000	-	-		oto101341
orthoMCL	1	0.900	-	-		OOG6_102375
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R985
SonicParanoid	1	1.000	-	-		X2240
TreeFam	1	0.960	-	-
	14	13.860