Protein Alignment Prp5 and prp28

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_587984.1
• Gene: prp28 / 2538728
• PomBaseID: SPCC63.11
• Length: 662
• Species: Schizosaccharomyces pombe
• Alignment Length: 755
• Identity: 220/755 - (29%)
• Similarity: 355/755 - (47%)
• Gaps: 124/755 - (16%)

  Fly   174 SEEEVEEIDKEEQQRRLEQEMIKRRERIERWRAERKRDTKAAVVAPSLVNSAKKWSLEDESEEDD 238
            :::.:..:::..||:|:::|...|.:.:.  :|||.|                 .:||...:|.:
pombe     3 AQDSIPSLEQLVQQKRVKEEKAARPKFLS--KAERAR-----------------LALERRQKEVE 48

  Fly   239 SNPAPPLDSGKKDAEPDSPPSKFHSIRKRFDDDVVESKFSPVKRPTFSKSFGKLGIGLATKAEAD 303
            ...|...|             |...:|||                ||:..       |.....||
pombe    49 EAKAKQND-------------KLLDLRKR----------------TFTNH-------LENNELAD 77

  Fly   304 IKKEPPPVDTKKEIKKKPEPVAAKMEIVEEPTVAAGEKTKKEPEQPHVGAKSEPEVEDKPQPEAE 368
            .:|           |.:...|::.....|  :.|..|.......|.::|.|  |.|..|.:..|:
pombe    78 DEK-----------KSQVSSVSSNNSGTE--SSATDEAFSMTIRQRYMGIK--PPVVKKRRRNAD 127

  Fly   369 PEDEIDPLDAYMQEVNNEMRRVNNFVNPPAKSQ--GVVILTGVAKKKTTTLKKGEVIEQNMDSLE 431
            .:...| .||    .::.|:......:|.|...  |...|.|...:.....|....:.|.:  |:
pombe   128 KKFVFD-WDA----TDDTMKDAETSASPEATIAVFGRGKLGGFDDQSIRKAKSNSGLIQRL--LQ 185

  Fly   432 YSSEDELEDIRDTAVNLAMKHRKELAKIDHSSVTYAPFRKNFYVEVPELTRMTAADVEKYRSDLE 496
            .:.:|:..     |..|.....|...|||...|   |:|     |.| |..|...|....:.|.
pombe   186 GTEQDKAR-----AHELIQLQEKRAKKIDWDDV---PWR-----EKP-LEAMKPRDWRILKEDY- 235

  Fly   497 GIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKT 561
            .|.:||...|.|::.|.:.|:..:.::||:::.:::|:.||..|||.::..:||||||:||||||
pombe   236 NISIKGDDLPNPLRNWEEAGLPSEMLKVLKKVNYKEPSSIQRAAIPVLLQRKDLIGIAETGSGKT 300

  Fly   562 LAFILPMFRHILDQPSMEDGD---GAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVCVYGGTGI 623
            .|||:|:...|...|.:.:.:   |..|:::||||||..||..:..||::.||.|.|.|.||...
pombe   301 AAFIIPLIIAISKLPPLTESNMHLGPYAVVLAPTRELAQQIQVEGNKFAEPLGFRCVSVVGGHAF 365

  Fly   624 SEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIIDNV 688
            .||..::.:||.|:|.||||::|.|   ..|:..|.:.||||:||||||.|||||..|.:|:.::
pombe   366 EEQSFQMSQGAHIVVATPGRLLDCL---ERRLFVLSQCTYVVMDEADRMLDMGFEDDVNKILSSL 427

  Fly   689 RPD-------------------RQTVMFSATFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQH 734
            ...                   |||:|||||.|.::..||:..|.:|:.:.:|........|||.
pombe   428 PSSNASEKDGSILATANSSSSRRQTIMFSATLPPRVANLAKSYLIEPVMLTIGNIGQAVDRVEQR 492

  Fly   735 VVILNDDAKFFKLL-ELLGIYQEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDS 798
            |.:::||:|.::.: |:|...:.:..||:||:.:.|.:.:.:.|....:..::|||...|..|:.
pombe   493 VEMISDDSKKWRRVEEILESNRFSPPIIIFVNLKRNIEAIAKQLNAIGWHAVTLHGSKSQEQRER 557

  Fly   799 TIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITP 863
            .|...::....:|:||.:|.||:|:.::.||:||::....|||.||.||||||||.|:|.||:.|
pombe   558 AIEQLRNKTADILVATDIAGRGIDIPNVSLVLNYNMAKSIEDYTHRIGRTGRAGKSGTAITFLGP 622

  Fly   864 EQSRYAGDIIRAMDLSGTL-IPAEL---QALWTEYKALQE 899
            |.:....|:...:..|... ||.||   :|.:..:.|:.:
pombe   623 EDTDVYYDLRVLLSRSAKAHIPDELRNHEAAFVRHAAITQ 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	19/91 (21%)
		DEAD-like_helicase_N	454..899	CDD:475120	169/471 (36%)
		KH-I_DDX46	1121..1223	CDD:411901
prp28	NP_587984.1	SrmB	252..624	CDD:440279	141/374 (38%)