Protein Alignment CG6227 and Ddx46

DIOPT Version :9

• Sequence 1: NP_573020.2
• Gene: CG6227 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_620798.1
• Gene: Ddx46 / 245957
• RGDID: 708480
• Length: 1032
• Species: Rattus norvegicus
• Alignment Length: 1240
• Identity: 620/1240 - (50%)
• Similarity: 763/1240 - (61%)
• Gaps: 258/1240 - (20%)

  Fly    33 RDNRHDSRSRDYDMGKSRNGGGGGAGGGSRNMREDRKRGKDMISDRGKRDDKRRKCSRSKDYEKD 97
            |::|| .|.|....|:|          |||:      |.:.....|.||.|.||..||.:|..::
  Rat     3 RESRH-YRKRSASRGRS----------GSRS------RSRSPSDKRSKRGDDRRSRSRDRDRRRE 50

  Fly    98 NSPHYRRLDKDRDRDRDRDRQREKEREREKEKEREKEKERERDKDRERDRQR------------- 149
            .|   |..||.|.|.|||.|.| :.|.||:::.||:.:.|.||:.|.|.|.|
  Rat    51 RS---RSRDKRRSRSRDRKRLR-RSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGSKS 111

  Fly   150 ---EKESDSRRAAAAAPLIIPLLSTSCSEEEVEEIDKEEQ---------QRRLEQEMIKRRERIE 202
               |..|.|:..|..        ..|..|::.::.|||::         |.:||:||.||:||:|
  Rat   112 KKAENRSRSKEKAEG--------GDSSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVE 168

  Fly   203 RWRAERKRDTKAAVVAPSL------VNSAKKWSLEDESEEDDSNPAPPLDSGKKDAEPDSPPSKF 261
            :||.|:::  ||......|      :...|||||||:.:::|.
  Rat   169 KWREEQRK--KAMENIGELKKEIEEMKQGKKWSLEDDDDDEDD---------------------- 209

  Fly   262 HSIRKRFDDDVVESKFSPVKRPTFSKSFGKLGIGLATKAEADIKKEPPPVDTKKEIKKKPEPVAA 326
                                                            |.:.:||
  Rat   210 ------------------------------------------------PAEAEKE---------- 216

  Fly   327 KMEIVEEPTVAAGEKTKKEPEQPHVGAKSEPEVEDKPQPEAEPEDEIDPLDAYMQEVNNE----- 386
                        |.                 |:||         :|:|||||||:||..|
  Rat   217 ------------GN-----------------EMED---------EELDPLDAYMEEVKEEVKKFN 243

  Fly   387 MRRVNNFVNPPAKSQGVV--ILTGVAKKKTTT---LKKGEVIEQNMDSLEYSSEDELEDIRDTAV 446
            ||.|........||...|  ::|.|..||...   .||||::|.:.|::|||||:|..|::....
  Rat   244 MRSVKGGAGNEKKSGPTVTKVVTVVTTKKAVVDADKKKGELMENDQDAMEYSSEEEEVDLQTALT 308

  Fly   447 NLAMKHRKELAKIDHSSVTYAPFRKNFYVEVPELTRMTAADVEKYRSDLEGIQVKGKGCPKPIKT 511
            ....|.||.|..:||..:.|.|||||||||||||.:|:..:|..:|.::|||.|||||||||||:
  Rat   309 GYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGITVKGKGCPKPIKS 373

  Fly   512 WAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKTLAFILPMFRHILDQP 576
            |.|||:|.|.:..|::.|:|||||||.|||||||||||||||||||||||:||:|||||||:||.
  Rat   374 WVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPMFRHIMDQR 438

  Fly   577 SMEDGDGAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTP 641
            |:|:|:|.||:||.|||||.:||.|:.:||||:||||.|||||||||||||||||||||||||||
  Rat   439 SLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVYGGTGISEQIAELKRGAEIIVCTP 503

  Fly   642 GRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIIDNVRPDRQTVMFSATFPRQME 706
            |||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||.||
  Rat   504 GRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRIVDNVRPDRQTVMFSATFPRAME 568

  Fly   707 ALARRILKKPIEVIVGGRSVVCKEVEQHVVILNDDAKFFKLLELLGIYQEAGSIIVFVDKQENAD 771
            |||||||.|||||.||||||||.:|||.|:::.::.||.|||||||.|||:||:|:||||||:||
  Rat   569 ALARRILSKPIEVQVGGRSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESGSVIIFVDKQEHAD 633

  Fly   772 ILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPN 836
            .||:|||:||||||||||||||:||||.|.|||:|..:||:||||||||||||.|||||||..||
  Rat   634 GLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPN 698

  Fly   837 HYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRAMDLSGTLIPAELQALWTEYKALQEAE 901
            ||||||||.|||||||.||.||||||.:|:|||||||:|::||||.:|.:|:.||:::|..|:||
  Rat   699 HYEDYVHRAGRTGRAGNKGYAYTFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAE 763

  Fly   902 GKTVHTGGGFSGKGFKFDEQEFNAAKESKKLQKAALGLADSDDEEDIEQDIDQQIEQIFAAKRTV 966
            ||.:....|||||||||||.|...|.|.||||||||||.|||| ||...|||:|||.:|.:|:.|
  Rat   764 GKIIKKSSGFSGKGFKFDETEQALANERKKLQKAALGLQDSDD-EDAAVDIDEQIESMFNSKKRV 827

  Fly   967 KDTSAAATAAAAAAAAAAAAAAAVSGANPALASAAAQAAAAAAAANIAIAAASAPAAAGGAPSVA 1031
            ||.:|..|                                           :||||...|
  Rat   828 KDMAAPGT-------------------------------------------SSAPAPTAG----- 844

  Fly  1032 MGGALSSDKLELAKRLASKINSSKNLDTKGSVVTVEPMIK-----GPHVTGAAATLLTARTVAEQ 1091
                 :::|||:|||||.:||:.|||..:..|..::....     ||    ..|..::|:|:|||
  Rat   845 -----NAEKLEIAKRLALRINAQKNLGIESQVDVMQQATNAILRGGP----LLAPTVSAKTIAEQ 900

  Fly  1092 MAAKLNNKLNYQP--KEDEEGLGPLVGGTTNPFTKYEEELEINDFPQQARWKVTSKEALAQISEY 1154
            :|.|:|.||||.|  |::||   ...||.:..|.:||||||||||||.|||||||||||.:||||
  Rat   901 LAEKINAKLNYVPLEKQEEE---RQEGGQSESFKRYEEELEINDFPQTARWKVTSKEALQRISEY 962

  Fly  1155 SEAGLTVRGTYVPQGKNPPDGERKLYLAIESCSELAVQKAKREITRLIKEELLKLSSAHHVFNKG 1219
            |||.:|:||||.|.||.|.:||||:||||||.:||||||||.||||||||||::|.:::...|||
  Rat   963 SEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQKAKAEITRLIKEELIRLQNSYQPTNKG 1027

  Fly  1220 RYKVV 1224
            ||||:
  Rat  1028 RYKVL 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6227	NP_573020.2	SrmB	482..967	CDD:223587	362/484 (75%)
		DEADc	516..719	CDD:238167	170/202 (84%)
		HELICc	733..860	CDD:238034	95/126 (75%)
Ddx46	NP_620798.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..227		84/372 (23%)
		SrmB	344..826	CDD:223587	362/482 (75%)
		Q motif	372..400		15/27 (56%)
		DEADc	378..581	CDD:238167	170/202 (84%)
		DEAD box	529..532		2/2 (100%)
		Helicase_C	618..714	CDD:278689	76/95 (80%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	328	1.000	Domainoid score	I1137
eggNOG	1	0.900	-	-		E2759_KOG0334
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5430
Inparanoid	1	1.050	1050	1.000	Inparanoid score	I245
OMA	1	1.010	-	-		QHG54542
OrthoDB	1	1.010	-	-		D146665at33208
OrthoFinder	1	1.000	-	-		FOG0004627
OrthoInspector	1	1.000	-	-		oto97273
orthoMCL	1	0.900	-	-		OOG6_102375
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2240
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840