Protein Alignment CG6227 and ddx-46

DIOPT Version :9

• Sequence 1: NP_573020.2
• Gene: CG6227 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_001033411.1
• Gene: ddx-46 / 176943
• WormBaseID: WBGene00018776
• Length: 970
• Species: Caenorhabditis elegans
• Alignment Length: 1169
• Identity: 494/1169 - (42%)
• Similarity: 677/1169 - (57%)
• Gaps: 224/1169 - (19%)

  Fly    78 RGKRDDKRRKCSRSKDYEKDNSPHYRRLDKDRD-RDRDRDRQREKEREREKEKEREKEKERERDK 141
            ||:..:.:||.||||:.::..|...|...:.|: |||||||:|.:||:.::||.|::||:|:.:|
 Worm     3 RGEHKEHKRKRSRSKERKRSRSRSPRGSREHREHRDRDRDRERRRERDTDREKTRDREKQRDAEK 67

  Fly   142 DRERDRQREKESDSRRAAAAAPLIIPLLSTSCSEEEVEEIDKEEQQRRLEQEMI----KRRERIE 202
                  ::||||                .|:..|.|....|.||..:..|.|::    :||..:|
 Worm    68 ------KKEKES----------------KTAIFEMEESRNDTEEVMKMKEAELLQGVERRRRNVE 110

  Fly   203 RWRAERKRDTKAAVVAPSLVNSAKK-WSLEDESEEDDSNPAPPLDSGKKDAEPDSPPSKFHSIRK 266
            :|||::|::........|...|.|| |:||||.:||
 Worm   111 KWRAQKKKEELDLQSEQSDEKSEKKPWNLEDEDDED----------------------------- 146

  Fly   267 RFDDDVVESKFSPVKRPTFSKSFGKLGIGLATKAEADIKKEPPPVDTKKEIKKKPEPVAAKMEIV 331
                                              |.|||.|                     .|.
 Worm   147 ----------------------------------EFDIKNE---------------------GIS 156

  Fly   332 EEPTVAAGEKTKKEPEQPHVGAKSEPEVEDKPQPEAEPEDEIDPLDAYMQEVNNEMRRVNNFVNP 396
            ||..|...||.:|                      .:.:||.|||||:|:|:..:..:...  |.
 Worm   157 EENPVKMEEKVEK----------------------MDTDDEEDPLDAFMKEIATKNAKKTG--NS 197

  Fly   397 PAKSQGVVILTGVAKKKTTTLKKGEVIEQNMDSLEYSSEDELEDIRDTAVNLAMKHRKELAKIDH 461
            ..|:.|:|.:....|.:.   :||:|:| |.|:::...:|  .||...|.:|..|.|. ||:.||
 Worm   198 TQKASGIVTIVQEEKPEP---EKGQVLE-NEDNMDMVIDD--FDIETAAASLCHKGRM-LAQTDH 255

  Fly   462 SSVTYAPFRKNFYVEVPELTRMTAADVEKYRSDLEGIQVKGKGCPKPIKTWAQCGVSKKEMEVLR 526
            |.|.|..|:||||:|..|:.|||.|:|:.||.:|:.|.|||..|||||||||||||:.|.|.||:
 Worm   256 SKVYYRKFKKNFYIETEEIRRMTKAEVKAYREELDSITVKGIDCPKPIKTWAQCGVNLKMMNVLK 320

  Fly   527 RLGFEKPTPIQCQAIPAIMSGRDLIGIAKTGSGKTLAFILPMFRHILDQPSMEDGDGAIAIIMAP 591
            :..:.|||.||.||||:||||||:||||||||||||||:|||||||||||.:|:|||.||:|:||
 Worm   321 KFEYSKPTSIQAQAIPSIMSGRDVIGIAKTGSGKTLAFLLPMFRHILDQPELEEGDGPIAVILAP 385

  Fly   592 TRELCMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVT 656
            ||||.||..|:..||:|.|||:..|.|||.|||||||:|||||||:|||||||||:||||||:||
 Worm   386 TRELAMQTYKEANKFAKPLGLKVACTYGGVGISEQIADLKRGAEIVVCTPGRMIDVLAANSGKVT 450

  Fly   657 NLRRVTYVVLDEADRMFDMGFEPQVMRIIDNVRPDRQTVMFSATFPRQMEALARRILKKPIEVIV 721
            |||||||:||||||||||.|||||:|::::|:|||:|||:|||||||.||||||::|.||:|::|
 Worm   451 NLRRVTYLVLDEADRMFDKGFEPQIMKVVNNIRPDKQTVLFSATFPRHMEALARKVLDKPVEILV 515

  Fly   722 GGRSVVCKEVEQHVVILNDDAKFFKLLELLGIYQEAGSIIVFVDKQENADILLRDLMKASYPCMS 786
            ||:||||.::.|:.||..:..||.|||||||:|.|.||.||||||||.||.::..||:..|..::
 Worm   516 GGKSVVCSDITQNAVICAEHQKFLKLLELLGMYYEEGSSIVFVDKQEKADDIVDQLMRTGYNSVA 580

  Fly   787 -LHGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGR 850
             |||||||.||||:|.|||:|.:::|:||||||||||||:||||||||.||||||||||.|||||
 Worm   581 PLHGGIDQHDRDSSIADFKTGVIKVLVATSVAARGLDVKNLILVVNYDCPNHYEDYVHRVGRTGR 645

  Fly   851 AGKKGSAYTFITPE-QSRYAGDIIRAMDLSGTLIPAELQALWTEYKALQEAEGKTVHTGG-GFSG 913
            ||:||.||||:.|| |.:.||:|.||.:.:|...||:|:|::..:|:...||||.|..|| ||.|
 Worm   646 AGRKGYAYTFVLPEHQEKMAGEICRAFETAGCKPPADLKAMFERFKSEMAAEGKEVKLGGKGFEG 710

  Fly   914 KGFKFDEQEFNAAKESKKLQKAALGLADSDDEEDIEQDIDQQIEQIFAAKRTV---KDTSAAATA 975
            .|:|:||.|..|....|::.:...|:....|::|   |:::|:..:...||.|   |..|...::
 Worm   711 SGYKYDEGEAEADANKKRMTRLVHGMEAGGDDDD---DLEEQLSSMIKTKRRVVHGKPQSEKPSS 772

  Fly   976 AAAAAAAAAAAAAAVSGANPALASAAAQAAAAAAAANIAIAAASAPAAAGGAPSVAMGGALSSDK 1040
            ::..|            .|...|...|..|...|.
 Worm   773 SSGNA------------KNDREAGKRADQAKLKAE------------------------------ 795

  Fly  1041 LELAKRLASKINSSKNLDTKGSVVTVEPMIKGPHVTGAAATLLTARTVAEQMAAKLNNKLNYQPK 1105
             ||:.||.......:.::...:.:|.|.:::|..|   |...::|..:|::.|.:||.||||
 Worm   796 -ELSTRLKGASQVVQPVEKTAAQLTAEAVLRGAEV---APAQMSAAMLAKEKANRLNEKLNY--- 853

  Fly  1106 EDEEGLGPLVGGTTNP-------FTKYEEELEINDFPQQARWKVTSKEALAQISEYSEAGLTVRG 1163
                     :||...|       :..:|||.:|||||||.|:|:.|:|::..::|.:|.|::|||
 Worm   854 ---------LGGEAAPTQQQEEAWEYFEEEWDINDFPQQVRYKICSRESVGHVAELAEVGISVRG 909

  Fly  1164 TYVPQGKNPPDGERKLYLAIESCSELAVQKAKREITRLIKEELLKLSSAHHVFNKG----RYKV 1223
            .:||.||.|.:|||:|:|.:|:.||..::.||.||.|::||...:|::.   ..:|    ||||
 Worm   910 VHVPPGKEPKNGERRLHLLLEARSERNLKAAKEEIIRIMKEAFRQLTAQ---LQRGGTQARYKV 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6227	NP_573020.2	SrmB	482..967	CDD:223587	308/490 (63%)
		DEADc	516..719	CDD:238167	149/202 (74%)
		HELICc	733..860	CDD:238034	87/127 (69%)
ddx-46	NP_001033411.1	SrmB	276..793	CDD:223587	315/531 (59%)
		DEADc	316..514	CDD:238167	147/197 (75%)
		HELICc	534..655	CDD:238034	84/120 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166434
Domainoid	1	1.000	284	1.000	Domainoid score	I861
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5430
Inparanoid	1	1.050	765	1.000	Inparanoid score	I275
Isobase	1	0.950	-	0	Normalized mean entropy	S1040
OMA	1	1.010	-	-		QHG54542
OrthoDB	1	1.010	-	-		D146665at33208
OrthoFinder	1	1.000	-	-		FOG0004627
OrthoInspector	1	1.000	-	-		oto18403
orthoMCL	1	0.900	-	-		OOG6_102375
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R985
SonicParanoid	1	1.000	-	-		X2240
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890