Protein Alignment Prp5 and DDX53

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_874358.2
• Gene: DDX53 / 168400
• HGNCID: 20083
• Length: 631
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 190/551 - (34%)
• Similarity: 294/551 - (53%)
• Gaps: 54/551 - (9%)

  Fly   380 MQEVNNEMR-RVNNFVNPPAKSQGVVILTGVAKKKT---TTLKKGEVIEQNMDSLEYSSEDELE- 439
            :|.:|.|.. :|..|.|...|          ||.|.   |.::|.|         .|:||..::
Human    82 IQIINGESEAKVRIFGNREMK----------AKAKAAIETLIRKQE---------SYNSESSVDN 127

  Fly   440 --------------DIRDTAVNLAMKHRKELAKIDHSSVTYA---PFRKNFYVEVPELTRMTAAD 487
                          ||...|..|:...|...|.::.....:|   |.:||||:|....:.|:...
Human   128 AASQTPIGRNLGRNDIVGEAEPLSNWDRIRAAVVECEKRKWADLPPVKKNFYIESKATSCMSEMQ 192

  Fly   488 VEKYRSDLEGIQV------KGKGCPKPIKTWAQCGVSKKE-MEVLRRLGFEKPTPIQCQAIPAIM 545
            |..:|.:...|..      :.:..|||...:........: ::.:.|:|..||||||.||.|.|:
Human   193 VINWRKENFNITCDDLKSGEKRLIPKPTCRFKDAFQQYPDLLKSIIRVGIVKPTPIQSQAWPIIL 257

  Fly   546 SGRDLIGIAKTGSGKTLAFILPMFRHILDQP-SMEDGDGAIAIIMAPTRELCMQIGKDIRKFSKS 609
            .|.|||.:|:||:||||::::|.|.|:..|| |.|..:|...:::.|||||.:.:..:..|:|..
Human   258 QGIDLIVVAQTGTGKTLSYLMPGFIHLDSQPISREQRNGPGMLVLTPTRELALHVEAECSKYSYK 322

  Fly   610 LGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFD 674
             ||:.:|:|||...:.||.::.:|.:||:.||||:.|:...||   .|||.:||:|:||||:|.|
Human   323 -GLKSICIYGGRNRNGQIEDISKGVDIIIATPGRLNDLQMNNS---VNLRSITYLVIDEADKMLD 383

  Fly   675 MGFEPQVMRIIDNVRPDRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSVVC-KEVEQHVVIL 738
            |.||||:.:|:.:|||||||||.|||:|..:..||...||.|:.|.||..::|. ..|:|::::.
Human   384 MEFEPQIRKILLDVRPDRQTVMTSATWPDTVRQLALSYLKDPMIVYVGNLNLVAVNTVKQNIIVT 448

  Fly   739 NDDAKFFKLLELLGIYQEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDF 803
            .:..|.....|.:........:|:||.::..||.|..|.........||||..:|.|::..:.||
Human   449 TEKEKRALTQEFVENMSPNDKVIMFVSQKHIADDLSSDFNIQGISAESLHGNSEQSDQERAVEDF 513

  Fly   804 KSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRY 868
            |||.:::||.|.:.:||||:.|:..|.|||.|.:.:.||||.|..||.||.|::.|.||...|:.
Human   514 KSGNIKILITTDIVSRGLDLNDVTHVYNYDFPRNIDVYVHRVGYIGRTGKTGTSVTLITQRDSKM 578

  Fly   869 AGDIIRAMDLSGTLIPAELQALWTEYKALQE 899
            ||::|:.:|.:...:|.:|..:..:||..|:
Human   579 AGELIKILDRANQSVPEDLVVMAEQYKLNQQ 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653	1/2 (50%)
		DEAD-like_helicase_N	454..899	CDD:475120	168/456 (37%)
		KH-I_DDX46	1121..1223	CDD:411901
DDX53	NP_874358.2	KH-I_DDX43_DDX53	50..115	CDD:411858	11/42 (26%)
		Q motif	222..250		7/27 (26%)
		SrmB	231..625	CDD:440279	154/383 (40%)
		DEAD box	376..379		2/2 (100%)