Protein Alignment Prp5 and Ddx3x

DIOPT Version :10

• Sequence 1: NP_573020.2
• Gene: Prp5 / 32464
• FlyBaseID: FBgn0030631
• Length: 1224
• Species: Drosophila melanogaster
• Sequence 2: NP_034158.1
• Gene: Ddx3x / 13205
• MGIID: 103064
• Length: 662
• Species: Mus musculus
• Alignment Length: 477
• Identity: 175/477 - (36%)
• Similarity: 263/477 - (55%)
• Gaps: 37/477 - (7%)

  Fly   484 TAADVEKYRSDLEGIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGR 548
            |..:.||| .|:. ::..|..||..|::::...:.:..|..:....:.:|||:|..|||.|...|
Mouse   156 TGINFEKY-DDIP-VEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKR 218

  Fly   549 DLIGIAKTGSGKTLAFILPMFRHILDQPSMEDGDG------------------AIAIIMAPTREL 595
            ||:..|:||||||.||:||:...|     ..||.|                  .|::::||||||
Mouse   219 DLMACAQTGSGKTAAFLLPILSQI-----YADGPGEALRAMKENGRYGRRKQYPISLVLAPTREL 278

  Fly   596 CMQIGKDIRKFSKSLGLRPVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRR 660
            .:||.::.||||....:||..||||..|.:||.:|:||..::|.||||::||:  ..|:: .|..
Mouse   279 AVQIYEEARKFSYRSRVRPCVVYGGAEIGQQIRDLERGCHLLVATPGRLVDMM--ERGKI-GLDF 340

  Fly   661 VTYVVLDEADRMFDMGFEPQVMRII--DNVRPD--RQTVMFSATFPRQMEALARRILKKPIEVIV 721
            ..|:||||||||.|||||||:.||:  |.:.|.  |.|:|||||||::::.|||..|.:.|.:.|
Mouse   341 CKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAV 405

  Fly   722 GGRSVVCKEVEQHVVILNDDAKFFKLLELLGIYQEAGSIIVFVDKQENADILLRDLMKASYPCMS 786
            |......:.:.|.||.:.:..|...||:||....:....:|||:.::.||.|...|....|.|.|
Mouse   406 GRVGSTSENITQKVVWVEEIDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTS 470

  Fly   787 LHGGIDQFDRDSTIIDFKSGKVRLLIATSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRA 851
            :||...|.||:..:..|:|||..:|:||:|||||||:.::..|:|:|:|:..|:||||.|||||.
Mouse   471 IHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRV 535

  Fly   852 GKKGSAYTFITPEQSRYAGDIIRAMDLSGTLIPAELQALWTE--YKALQEAEGKTVHTGGGFSGK 914
            |..|.|.:|..........|::..:..:...:|:.|:.:..|  ||.......|:....|||..:
Mouse   536 GNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAFEHHYKGSSRGRSKSSRFSGGFGAR 600

  Fly   915 GFKFDEQEFNAAKESKKLQKAA 936
            .::   |...|:..|....:|:
Mouse   601 DYR---QSSGASSSSFSSSRAS 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp5	NP_573020.2	Trypan_PARP	<291..383	CDD:368653
		DEAD-like_helicase_N	454..899	CDD:475120	167/438 (38%)
		KH-I_DDX46	1121..1223	CDD:411901
Ddx3x	NP_034158.1	Required for TBK1 and IKBKE-dependent IFNB1 activation. /evidence=ECO:0000250|UniProtKB:O00571	2..139
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:O00571	12..21
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..144
		Interaction with EIF4E. /evidence=ECO:0000250|UniProtKB:O00571	38..44
		Interaction with GSK3B. /evidence=ECO:0000250|UniProtKB:O00571	100..662		175/477 (37%)
		Interaction with IKBKE. /evidence=ECO:0000250|UniProtKB:O00571	100..110
		Interaction with CHUK. /evidence=ECO:0000250|UniProtKB:O00571	139..172		5/17 (29%)
		DEADc_DDX3	160..410	CDD:350809	105/259 (41%)
		Q motif	180..208		4/27 (15%)
		Involved in stimulation of ATPase activity by DNA and RNA, nucleic acid binding and unwinding. /evidence=ECO:0000250|UniProtKB:O00571	250..259		0/8 (0%)
		DEAD box	347..350		2/2 (100%)
		SF2_C_DEAD	415..545	CDD:350174	54/129 (42%)
		Interaction with NXF1. /evidence=ECO:0000250|UniProtKB:O00571	536..661		18/87 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..633		4/22 (18%)