DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6227 and DDX42

DIOPT Version :9

Sequence 1:	NP_573020.2	Gene:	CG6227 / 32464	FlyBaseID:	FBgn0030631	Length:	1224	Species:	Drosophila melanogaster
Sequence 2:	NP_031398.2	Gene:	DDX42 / 11325	HGNCID:	18676	Length:	938	Species:	Homo sapiens

Alignment Length:	831	Identity:	285/831 - (34%)
Similarity:	425/831 - (51%)	Gaps:	100/831 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 LDSGKKDAEPDSPPSKFHSIRKRFDDDVVESKFSPVKRPTFSKSFGKLGIGLATKAEADIKKEPP 309
            :.:|||: || ..|.:.||                    .|..:....|.|         |..||
Human    21 ISAGKKE-EP-KLPQQSHS--------------------AFGATSSSSGFG---------KSAPP 54

  Fly   310 PVDTKKEIKKKPEPVAAKMEIVEEPTVAAGEKTKKEPEQPHVGAKSEPEVEDKPQPEAEPEDEID 374
            .:.:..:|..|......:....|:.     |:.....:.|::.|::.|..:.......:.:.:.|
Human    55 QLPSFYKIGSKRANFDEENAYFEDE-----EEDSSNVDLPYIPAENSPTRQQFHSKPVDSDSDDD 114

  Fly   375 PLDAYMQEVNN----EMRRVNNFVNPPAKSQGV-----------VILTGVAKKKTTTLKKGEVIE 424
            ||:|:|.||.:    :|:|:..........:|:           .....:|:..|.    |.|.|
Human   115 PLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTA----GVVQE 175

  Fly   425 QNMDSLEYSSEDELEDIRDTAVNLAMKHRKELAKIDHSSVTYAPFRKNFYVEVPELTRMTAADVE 489
            :..|:|||.|:       ...:....|....|..||||.:.|.||.||||.|..|:|.:|...:.
Human   176 EEEDNLEYDSD-------GNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLI 233

  Fly   490 KYRSDLEGIQVKGKGCPKPIKTWAQCGVSKKEMEVLRRLGFEKPTPIQCQAIPAIMSGRDLIGIA 554
            ..|..| .::|.|...|:|..::|..|..::.|..:|:..:.:|||||||.:|..:||||:||||
Human   234 DLRHKL-NLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIA 297

  Fly   555 KTGSGKTLAFILPMFRHILDQPSMEDGDGAIAIIMAPTRELCMQIGKDIRKFSKSLGLRPVCVYG 619
            |||||||.|||.||..||:||..:|.|||.||:|:.||||||.||..:.::|.|:..||.|.|||
Human   298 KTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAVYG 362

  Fly   620 GTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMRI 684
            |..:.||...|:.||||:||||||:||.:   ..:.|||:||:|:|.||||||||||||.||..|
Human   363 GGSMWEQAKALQEGAEIVVCTPGRLIDHV---KKKATNLQRVSYLVFDEADRMFDMGFEYQVRSI 424

  Fly   685 IDNVRPDRQTVMFSATFPRQMEALARRILKKPIEVIVGGRSVVCKEVEQHVVILND-DAKFFKLL 748
            ..:|||||||::|||||.:::|.|||.||..||.|:.|......::|.|.|.||:. .:|:..|.
Human   425 ASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLT 489

  Fly   749 ELLGIYQEAGSIIVFVDKQENADILLRDLMKASYPCMSLHGGIDQFDRDSTIIDFKSGKVRLLIA 813
            ..|..:..:||:::||.|:.||:.|..:|.:..:....|||.:||.:|:..|.|||...:.:|:|
Human   490 RRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVA 554

  Fly   814 TSVAARGLDVKDLILVVNYDVPNHYEDYVHRCGRTGRAGKKGSAYTFITPEQSRYAGDIIRAMD- 877
            |.|||||||:..:..|:||||....:.:.||.|||||||:||.|||.:||:.|.:|||::|.::
Human   555 TDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEG 619

  Fly   878 ----LSGTLIPAELQALWTEYKALQEAEGKTVHTGGGFSGKGFK---------FDEQEFNAAK-- 927
                :|..|:...:|..|......:..:||.::.|||  |.|::         .|....|...
Human   620 ANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGG--GLGYRERPGLGSENMDRGNNNVMSNY 682

  Fly   928 ESKKLQKAALGLADSDDEEDIEQDIDQQIEQIFAAKRTVKDTSAAATAAAAAAAAAAAAAAAV-- 990
            |:.|....|:|    |....::.....|.:..|.| .::.:..|.::||.|:...:|.:..:|
Human   683 EAYKPSTGAMG----DRLTAMKAAFQSQYKSHFVA-ASLSNQKAGSSAAGASGWTSAGSLNSVPT 742

  Fly   991 -------SGANPALASAAAQAAAAAAAANIAIAAASAPAA-AGGAPSVAMG 1033
                   :..:..:.|||..........||:.|..:.|:| |.|..:.|.|
Human   743 NSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASG 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6227	NP_573020.2	SrmB	482..967	CDD:223587	210/501 (42%)
		DEADc	516..719	CDD:238167	116/202 (57%)
		HELICc	733..860	CDD:238034	54/127 (43%)
DDX42	NP_031398.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..114		21/128 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..203		5/27 (19%)
		Q motif	253..281		8/27 (30%)
		PRK10590	254..688	CDD:236722	197/438 (45%)
		DEADc	255..459	CDD:238167	117/206 (57%)
		DEAD box	407..410		2/2 (100%)
		HELICc	470..601	CDD:238034	55/130 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..938		13/57 (23%)
		Necessary for interaction with TP53BP2. /evidence=ECO:0000269\|PubMed:19377511	738..833		13/56 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D146665at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920